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Asymmetric cupula displacement due to endolymph vortex in the human semicircular canal.

Abstract

The vestibular system in the inner ear senses angular head manoeuvres by endolymph fluid which deforms a gelatinous sensory structure (the cupula). We constructed computer models that include both the endolymph flow (using CFD modelling), the cupula deformation (using FEM modelling), and the interaction between both (using fluid-structure interaction modelling). In the wide utricle, we observe an endolymph vortex. In the initial time steps, both the displacement of the cupula and its restorative forces are still small. As a result, the endolymph vortex causes the cupula to deform asymmetrically in an S-shape. The asymmetric deflection increases the cupula strain near the crista and, as a result, enhances the sensitivity of the vestibular system. Throughout the head manoeuvre, the maximal cupula strain is located at the centre of the crista. The hair cells at the crista centre supply irregularly spiking afferents, which are more sensitive than the afferents from the periphery. Hence, the location of the maximal strain at the crista may also increase the sensitivity of the semicircular canal, but this remains to be tested. The cupula overshoots its relaxed position in a simulation of the Dix-Hallpike head manoeuvre (3 s in total). A much faster head manoeuvre of 0.222 s showed to be too short to cause substantial cupula overshoot, because the cupula time scale of both models (estimated to be 3.3 s) is an order of magnitude larger than the duration of this manoeuvre.

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  • Authors+Show Affiliations

    ,

    Laboratory of Functional Morphology, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium. jana.goyens@uantwerpen.be.

    ,

    Laboratory for Aero and Hydrodynamics, Delft University of Technology, Mekelweg 2, 2628 LD, Delft, The Netherlands.

    ,

    Laboratory for Aero and Hydrodynamics, Delft University of Technology, Mekelweg 2, 2628 LD, Delft, The Netherlands.

    Laboratory for Aero and Hydrodynamics, Delft University of Technology, Mekelweg 2, 2628 LD, Delft, The Netherlands.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31069593

    Citation

    Goyens, J, et al. "Asymmetric Cupula Displacement Due to Endolymph Vortex in the Human Semicircular Canal." Biomechanics and Modeling in Mechanobiology, 2019.
    Goyens J, Pourquie MJBM, Poelma C, et al. Asymmetric cupula displacement due to endolymph vortex in the human semicircular canal. Biomech Model Mechanobiol. 2019.
    Goyens, J., Pourquie, M. J. B. M., Poelma, C., & Westerweel, J. (2019). Asymmetric cupula displacement due to endolymph vortex in the human semicircular canal. Biomechanics and Modeling in Mechanobiology, doi:10.1007/s10237-019-01160-2.
    Goyens J, et al. Asymmetric Cupula Displacement Due to Endolymph Vortex in the Human Semicircular Canal. Biomech Model Mechanobiol. 2019 May 8; PubMed PMID: 31069593.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Asymmetric cupula displacement due to endolymph vortex in the human semicircular canal. AU - Goyens,J, AU - Pourquie,M J B M, AU - Poelma,C, AU - Westerweel,J, Y1 - 2019/05/08/ PY - 2018/07/26/received PY - 2019/04/26/accepted PY - 2019/5/10/entrez KW - Balance KW - Computational fluid dynamics KW - Finite element model KW - Fluid–structure interaction KW - Navier–Stokes equations KW - Time constant KW - Vestibular system JF - Biomechanics and modeling in mechanobiology JO - Biomech Model Mechanobiol N2 - The vestibular system in the inner ear senses angular head manoeuvres by endolymph fluid which deforms a gelatinous sensory structure (the cupula). We constructed computer models that include both the endolymph flow (using CFD modelling), the cupula deformation (using FEM modelling), and the interaction between both (using fluid-structure interaction modelling). In the wide utricle, we observe an endolymph vortex. In the initial time steps, both the displacement of the cupula and its restorative forces are still small. As a result, the endolymph vortex causes the cupula to deform asymmetrically in an S-shape. The asymmetric deflection increases the cupula strain near the crista and, as a result, enhances the sensitivity of the vestibular system. Throughout the head manoeuvre, the maximal cupula strain is located at the centre of the crista. The hair cells at the crista centre supply irregularly spiking afferents, which are more sensitive than the afferents from the periphery. Hence, the location of the maximal strain at the crista may also increase the sensitivity of the semicircular canal, but this remains to be tested. The cupula overshoots its relaxed position in a simulation of the Dix-Hallpike head manoeuvre (3 s in total). A much faster head manoeuvre of 0.222 s showed to be too short to cause substantial cupula overshoot, because the cupula time scale of both models (estimated to be 3.3 s) is an order of magnitude larger than the duration of this manoeuvre. SN - 1617-7940 UR - https://www.unboundmedicine.com/medline/citation/31069593/Asymmetric_cupula_displacement_due_to_endolymph_vortex_in_the_human_semicircular_canal L2 - https://dx.doi.org/10.1007/s10237-019-01160-2 DB - PRIME DP - Unbound Medicine ER -