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Serological screening for celiac disease in children with systemic lupus erythematosus.
Eur J Rheumatol 2019; 6(3):142-145EJ

Abstract

OBJECTIVE

The aim of the present study was to investigate the frequency of celiac disease (CD) in patients with juvenile systemic lupus erythematosus (JSLE) and the potential association of JSLE and CD.

METHODS

This was a cross-sectional study performed from October 2015 to October 2017. A total of 50 patients with JSLE were included in the study. The levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in all patients. Subjects with increased tTG were further evaluated for anti-endomysial antibodies (EMAs). Gastroduodenoscopy and intestinal biopsy were performed in those with increased EMA levels to confirm the diagnosis of CD.

RESULTS

The study included 44 (88.0%) female and 6 (12.0%) male patients. Of the 50 patients, 30 (60.0%) received corticosteroids, and only 4 (8.0%) received no therapy at the time of the study. Only 3 (6.0%) patients were positive for tTG IgA. Patients with positive tTG IgA were then tested for EMA IgA antibodies, and none of them had a positive result.

CONCLUSION

We did not find CD in children with systemic lupus erythematosus. Studies with more patients with JSLE are needed to conclude a more precise result.

Authors+Show Affiliations

Department of Pediatric Gastroenterology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Gastroenterology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Gastroenterology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Gastroenterology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31070578

Citation

Şahin, Yasin, et al. "Serological Screening for Celiac Disease in Children With Systemic Lupus Erythematosus." European Journal of Rheumatology, vol. 6, no. 3, 2019, pp. 142-145.
Şahin Y, Şahin S, Adrovic A, et al. Serological screening for celiac disease in children with systemic lupus erythematosus. Eur J Rheumatol. 2019;6(3):142-145.
Şahin, Y., Şahin, S., Adrovic, A., Kutlu, T., Çokuğras, F. Ç., Barut, K., ... Kasapçopur, Ö. (2019). Serological screening for celiac disease in children with systemic lupus erythematosus. European Journal of Rheumatology, 6(3), pp. 142-145. doi:10.5152/eurjrheum.2019.18130.
Şahin Y, et al. Serological Screening for Celiac Disease in Children With Systemic Lupus Erythematosus. Eur J Rheumatol. 2019 Apr 22;6(3):142-145. PubMed PMID: 31070578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological screening for celiac disease in children with systemic lupus erythematosus. AU - Şahin,Yasin, AU - Şahin,Sezgin, AU - Adrovic,Amra, AU - Kutlu,Tufan, AU - Çokuğras,Fügen Çullu, AU - Barut,Kenan, AU - Erkan,Tülay, AU - Kasapçopur,Özgür, Y1 - 2019/04/22/ PY - 2018/08/05/received PY - 2019/03/11/accepted PY - 2019/5/10/pubmed PY - 2019/5/10/medline PY - 2019/5/10/entrez SP - 142 EP - 145 JF - European journal of rheumatology JO - Eur J Rheumatol VL - 6 IS - 3 N2 - OBJECTIVE: The aim of the present study was to investigate the frequency of celiac disease (CD) in patients with juvenile systemic lupus erythematosus (JSLE) and the potential association of JSLE and CD. METHODS: This was a cross-sectional study performed from October 2015 to October 2017. A total of 50 patients with JSLE were included in the study. The levels of total IgA and tissue transglutaminase (tTG) IgA antibody were measured in all patients. Subjects with increased tTG were further evaluated for anti-endomysial antibodies (EMAs). Gastroduodenoscopy and intestinal biopsy were performed in those with increased EMA levels to confirm the diagnosis of CD. RESULTS: The study included 44 (88.0%) female and 6 (12.0%) male patients. Of the 50 patients, 30 (60.0%) received corticosteroids, and only 4 (8.0%) received no therapy at the time of the study. Only 3 (6.0%) patients were positive for tTG IgA. Patients with positive tTG IgA were then tested for EMA IgA antibodies, and none of them had a positive result. CONCLUSION: We did not find CD in children with systemic lupus erythematosus. Studies with more patients with JSLE are needed to conclude a more precise result. SN - 2147-9720 UR - https://www.unboundmedicine.com/medline/citation/31070578/Serological_screening_for_celiac_disease_in_children_with_systemic_lupus_erythematosus L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31070578/ DB - PRIME DP - Unbound Medicine ER -