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Effects of Silver Nitrate are a Conservative Estimate for the Effects of Silver Nanoparticles on Algae Growth and Daphnia magna Reproduction.
Environ Toxicol Chem. 2019 08; 38(8):1701-1713.ET

Abstract

Silver (Ag) salts have been shown to be highly toxic to freshwater organisms. There is nevertheless still a high level of uncertainty as to the aquatic effects of Ag nanoparticles (AgNPs), and how these relate to the effects of soluble Ag salts. As part of the substance evaluation for Ag of the European Union Registration, Evaluation, Authorisation, and Restriction of Chemicals regulation, we have generated new data to justify read-across from soluble Ag salts to AgNPs. The aquatic toxicity to algae growth and Daphnia magna reproduction, fate, and behavior of AgNO3 versus AgNPs were tested and compared. Chloride salts in the test media were replaced with equimolar concentrations of nitrate salts. Total Ag, "conventionally" dissolved Ag (0.45 µm), and "truly" dissolved Ag (3 kDa) were determined. Algae were the most sensitive test species to AgNO3 (10% effect concentration [EC10] 0.10 µg Ag/L) when expressed as conventionally dissolved Ag. The corresponding value for AgNPs was 0.26 µg/L. For D. magna reproduction, the lowest EC10 values were 3.49 µg Ag/L for AgNO3 and 33.4 µg Ag/L for AgNPs. Using measured Ag concentrations, AgNO3 was experimentally shown to be more toxic than AgNPs for all Ag fractions. We explain these observations by a different dissolution behavior of AgNO3 versus AgNPs. The results provide experimental confirmation that AgNO3 can be used as a conservative estimate for the aquatic effects of AgNPs at comparable Ag concentrations. Environ Toxicol Chem 2019;38:1701-1713. © 2019 SETAC.

Authors+Show Affiliations

European Precious Metals Federation, Brussels, Belgium.ARCHE Consulting, Ghent (Wondelgem), Belgium.wca environment, Faringdon, Oxfordshire, UK.European Precious Metals Federation, Brussels, Belgium. ARCHE Consulting, Ghent (Wondelgem), Belgium.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31070798

Citation

Mertens, Jelle, et al. "Effects of Silver Nitrate Are a Conservative Estimate for the Effects of Silver Nanoparticles On Algae Growth and Daphnia Magna Reproduction." Environmental Toxicology and Chemistry, vol. 38, no. 8, 2019, pp. 1701-1713.
Mertens J, Oorts K, Leverett D, et al. Effects of Silver Nitrate are a Conservative Estimate for the Effects of Silver Nanoparticles on Algae Growth and Daphnia magna Reproduction. Environ Toxicol Chem. 2019;38(8):1701-1713.
Mertens, J., Oorts, K., Leverett, D., & Arijs, K. (2019). Effects of Silver Nitrate are a Conservative Estimate for the Effects of Silver Nanoparticles on Algae Growth and Daphnia magna Reproduction. Environmental Toxicology and Chemistry, 38(8), 1701-1713. https://doi.org/10.1002/etc.4463
Mertens J, et al. Effects of Silver Nitrate Are a Conservative Estimate for the Effects of Silver Nanoparticles On Algae Growth and Daphnia Magna Reproduction. Environ Toxicol Chem. 2019;38(8):1701-1713. PubMed PMID: 31070798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Silver Nitrate are a Conservative Estimate for the Effects of Silver Nanoparticles on Algae Growth and Daphnia magna Reproduction. AU - Mertens,Jelle, AU - Oorts,Koen, AU - Leverett,Dean, AU - Arijs,Katrien, Y1 - 2019/07/25/ PY - 2019/04/05/received PY - 2019/04/24/revised PY - 2019/05/03/accepted PY - 2019/5/10/pubmed PY - 2020/4/28/medline PY - 2019/5/10/entrez KW - Algae KW - Aquatic invertebrates KW - Aquatic toxicology KW - Dissolution KW - Silver SP - 1701 EP - 1713 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 38 IS - 8 N2 - Silver (Ag) salts have been shown to be highly toxic to freshwater organisms. There is nevertheless still a high level of uncertainty as to the aquatic effects of Ag nanoparticles (AgNPs), and how these relate to the effects of soluble Ag salts. As part of the substance evaluation for Ag of the European Union Registration, Evaluation, Authorisation, and Restriction of Chemicals regulation, we have generated new data to justify read-across from soluble Ag salts to AgNPs. The aquatic toxicity to algae growth and Daphnia magna reproduction, fate, and behavior of AgNO3 versus AgNPs were tested and compared. Chloride salts in the test media were replaced with equimolar concentrations of nitrate salts. Total Ag, "conventionally" dissolved Ag (0.45 µm), and "truly" dissolved Ag (3 kDa) were determined. Algae were the most sensitive test species to AgNO3 (10% effect concentration [EC10] 0.10 µg Ag/L) when expressed as conventionally dissolved Ag. The corresponding value for AgNPs was 0.26 µg/L. For D. magna reproduction, the lowest EC10 values were 3.49 µg Ag/L for AgNO3 and 33.4 µg Ag/L for AgNPs. Using measured Ag concentrations, AgNO3 was experimentally shown to be more toxic than AgNPs for all Ag fractions. We explain these observations by a different dissolution behavior of AgNO3 versus AgNPs. The results provide experimental confirmation that AgNO3 can be used as a conservative estimate for the aquatic effects of AgNPs at comparable Ag concentrations. Environ Toxicol Chem 2019;38:1701-1713. © 2019 SETAC. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/31070798/Effects_of_Silver_Nitrate_are_a_Conservative_Estimate_for_the_Effects_of_Silver_Nanoparticles_on_Algae_Growth_and_Daphnia_magna_Reproduction_ L2 - https://doi.org/10.1002/etc.4463 DB - PRIME DP - Unbound Medicine ER -