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Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? A Double Blind, Randomized Clinical Trial.
Horm Metab Res. 2019 May; 51(5):296-301.HM

Abstract

Hashimoto's thyroiditis (HT) is the most prevalent autoimmune disorder characterized by the destruction of thyroid cells caused by leukocytes and antibody-mediated immune processes accompanied by hypothyroidism. In recent years, evidence has emerged pointing to various roles for vitamin D, including, proliferation and differentiation of normal and cancer cells, cardiovascular function, and immunomodulation. Vitamin D deficiency has been especially demonstrated in HT patients. The aim of this study was to investigate the effect of vitamin D on circulating thyroid autoantibodies and thyroid hormones profile (T4, T3, and TSH) in females with HT. Forty-two women with HT disease were enrolled in this randomized clinical trial study and divided into vitamin D and placebo groups. Patients in the vitamin D and placebo groups received 50 000 IU vitamin D and placebo pearls, weekly for 3 months, respectively. The serum levels of 25-hydroxy vitamin D [25(OH) D], Ca++ion, anti-thyroperoxidase antibody (anti-TPO Ab), anti-thyroglobulin antibody (anti-Tg Ab), T4, T3, and TSH were measured at the baseline and at the end of the study using enzyme-linked immunosorbent assays. The results of this study showed a significant reduction of anti-Tg Ab and TSH hormone in the Vitamin D group compared to the start of the study; however, there was a no significant reduction of anti-TPO Ab in the Vitamin D group compared to the placebo group (p=0.08). No significant changes were observed in the serum levels of T3 and T4 hormones. Therefore, vitamin D supplementation can be helpful for alleviation of the disease activity in HT patients; however, further well controlled, large, longitudinal studies are needed to determine whether it can be introduced in clinical practice.

Authors+Show Affiliations

School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Immunology, School of Public Health Tehran University of Medical Science, Tehran, Iran.Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31071734

Citation

Chahardoli, Reza, et al. "Can Supplementation With Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? a Double Blind, Randomized Clinical Trial." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 51, no. 5, 2019, pp. 296-301.
Chahardoli R, Saboor-Yaraghi AA, Amouzegar A, et al. Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? A Double Blind, Randomized Clinical Trial. Horm Metab Res. 2019;51(5):296-301.
Chahardoli, R., Saboor-Yaraghi, A. A., Amouzegar, A., Khalili, D., Vakili, A. Z., & Azizi, F. (2019). Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? A Double Blind, Randomized Clinical Trial. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 51(5), 296-301. https://doi.org/10.1055/a-0856-1044
Chahardoli R, et al. Can Supplementation With Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? a Double Blind, Randomized Clinical Trial. Horm Metab Res. 2019;51(5):296-301. PubMed PMID: 31071734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? A Double Blind, Randomized Clinical Trial. AU - Chahardoli,Reza, AU - Saboor-Yaraghi,Ali-Akbar, AU - Amouzegar,Atieh, AU - Khalili,Davood, AU - Vakili,Azita Zadeh, AU - Azizi,Fereidoun, Y1 - 2019/05/09/ PY - 2019/5/10/entrez PY - 2019/5/10/pubmed PY - 2019/8/31/medline SP - 296 EP - 301 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 51 IS - 5 N2 - Hashimoto's thyroiditis (HT) is the most prevalent autoimmune disorder characterized by the destruction of thyroid cells caused by leukocytes and antibody-mediated immune processes accompanied by hypothyroidism. In recent years, evidence has emerged pointing to various roles for vitamin D, including, proliferation and differentiation of normal and cancer cells, cardiovascular function, and immunomodulation. Vitamin D deficiency has been especially demonstrated in HT patients. The aim of this study was to investigate the effect of vitamin D on circulating thyroid autoantibodies and thyroid hormones profile (T4, T3, and TSH) in females with HT. Forty-two women with HT disease were enrolled in this randomized clinical trial study and divided into vitamin D and placebo groups. Patients in the vitamin D and placebo groups received 50 000 IU vitamin D and placebo pearls, weekly for 3 months, respectively. The serum levels of 25-hydroxy vitamin D [25(OH) D], Ca++ion, anti-thyroperoxidase antibody (anti-TPO Ab), anti-thyroglobulin antibody (anti-Tg Ab), T4, T3, and TSH were measured at the baseline and at the end of the study using enzyme-linked immunosorbent assays. The results of this study showed a significant reduction of anti-Tg Ab and TSH hormone in the Vitamin D group compared to the start of the study; however, there was a no significant reduction of anti-TPO Ab in the Vitamin D group compared to the placebo group (p=0.08). No significant changes were observed in the serum levels of T3 and T4 hormones. Therefore, vitamin D supplementation can be helpful for alleviation of the disease activity in HT patients; however, further well controlled, large, longitudinal studies are needed to determine whether it can be introduced in clinical practice. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/31071734/Can_Supplementation_with_Vitamin_D_Modify_Thyroid_Autoantibodies__Anti_TPO_Ab_Anti_Tg_Ab__and_Thyroid_Profile__T3_T4_TSH__in_Hashimoto's_Thyroiditis_A_Double_Blind_Randomized_Clinical_Trial_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/a-0856-1044 DB - PRIME DP - Unbound Medicine ER -