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Serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis.
Acta Endocrinol (Copenh). 1987 Apr; 114(4):559-64.AE

Abstract

Serum total and free T4 and T3, thyroxine-binding globulin (TBG) and TSH, basal and 20, 30 and 60 min after TRH (200 micrograms, iv), were evaluated in 125 hypothyroid patients (38 with severe, 23 with mild, and 64 with subclinical hypothyroidism), in 35 euthyroid subjects with autoimmune thyroiditis, and in 51 healthy controls. T4/TBG and T3/TBG ratios were also calculated. A significant decrease in all indices of thyroid function except for T3 occurred simultaneously with a significant increase in basal and TRH-stimulated TSH levels from healthy subjects to subclinical hypothyroids, from subclinical to mild and from mild to severe hypothyroids; euthyroid patients with autoimmune thyroiditis did not differ from healthy subjects. All severe hypothyroid patients had low T4 as well as free T4 (FT4), free T3 (FT3), T4/TBG and T3/TBG ratios, but among mild and subclinical hypothyroids direct determination of FT4 and FT3 proved to be a better index of thyroid function than determination of T4 and T3 even after correction for TBG levels. FT4 was the most commonly abnormal index (19 of 23 subjects with mild and 14 of 64 with subclinical disease). Regression analysis showed that FT4, T4/TBG ratio, T4, and FT3 had a significant inverse correlation with TSH in hypothyroid patients. Discriminant analysis showed that among the thyroid parameters, FT4 is the variable which discriminates best between control subjects and the 3 groups of hypothyroid patients. These data extend previous reports and in a large series of patients confirm the biological meaning and the clinical value of direct measurement of serum free thyroid hormones in hypothyroidism.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3107297

Citation

Ferrari, C, et al. "Serum Free Thyroid Hormones in Different Degrees of Hypothyroidism and in Euthyroid Autoimmune Thyroiditis." Acta Endocrinologica, vol. 114, no. 4, 1987, pp. 559-64.
Ferrari C, Paracchi A, Parisio E, et al. Serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis. Acta Endocrinol. 1987;114(4):559-64.
Ferrari, C., Paracchi, A., Parisio, E., Codecasa, F., Mucci, M., Boghen, M., Gerevini, G., & Rampini, P. (1987). Serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis. Acta Endocrinologica, 114(4), 559-64.
Ferrari C, et al. Serum Free Thyroid Hormones in Different Degrees of Hypothyroidism and in Euthyroid Autoimmune Thyroiditis. Acta Endocrinol. 1987;114(4):559-64. PubMed PMID: 3107297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis. AU - Ferrari,C, AU - Paracchi,A, AU - Parisio,E, AU - Codecasa,F, AU - Mucci,M, AU - Boghen,M, AU - Gerevini,G, AU - Rampini,P, PY - 1987/4/1/pubmed PY - 1987/4/1/medline PY - 1987/4/1/entrez SP - 559 EP - 64 JF - Acta endocrinologica JO - Acta Endocrinol. VL - 114 IS - 4 N2 - Serum total and free T4 and T3, thyroxine-binding globulin (TBG) and TSH, basal and 20, 30 and 60 min after TRH (200 micrograms, iv), were evaluated in 125 hypothyroid patients (38 with severe, 23 with mild, and 64 with subclinical hypothyroidism), in 35 euthyroid subjects with autoimmune thyroiditis, and in 51 healthy controls. T4/TBG and T3/TBG ratios were also calculated. A significant decrease in all indices of thyroid function except for T3 occurred simultaneously with a significant increase in basal and TRH-stimulated TSH levels from healthy subjects to subclinical hypothyroids, from subclinical to mild and from mild to severe hypothyroids; euthyroid patients with autoimmune thyroiditis did not differ from healthy subjects. All severe hypothyroid patients had low T4 as well as free T4 (FT4), free T3 (FT3), T4/TBG and T3/TBG ratios, but among mild and subclinical hypothyroids direct determination of FT4 and FT3 proved to be a better index of thyroid function than determination of T4 and T3 even after correction for TBG levels. FT4 was the most commonly abnormal index (19 of 23 subjects with mild and 14 of 64 with subclinical disease). Regression analysis showed that FT4, T4/TBG ratio, T4, and FT3 had a significant inverse correlation with TSH in hypothyroid patients. Discriminant analysis showed that among the thyroid parameters, FT4 is the variable which discriminates best between control subjects and the 3 groups of hypothyroid patients. These data extend previous reports and in a large series of patients confirm the biological meaning and the clinical value of direct measurement of serum free thyroid hormones in hypothyroidism.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0001-5598 UR - https://www.unboundmedicine.com/medline/citation/3107297/Serum_free_thyroid_hormones_in_different_degrees_of_hypothyroidism_and_in_euthyroid_autoimmune_thyroiditis_ L2 - https://medlineplus.gov/hypothyroidism.html DB - PRIME DP - Unbound Medicine ER -