The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial.
Neuroscience. 2019 07 01; 410:176-182.N

Abstract

Aerobic training improves cognitive and brain outcomes across different populations and neurocognitive disorders of aging, including mild subcortical ischemic vascular cognitive impairment (SIVCI). However, little is known of the underlying mechanisms through which aerobic training exerts its beneficial effects on the brain. Recently, S100 calcium-binding protein B (S100B) has been proposed as a possible mediator of aerobic training. Thus we conducted a secondary analysis of data collected from the proof-of-concept single-blind randomized controlled trial (NCT01027858) in older adults with mild SIVCI to determine whether the beneficial effects of 6-months, thrice weekly, moderate-intensity aerobic training on cognitive performance is related to changes in S100B levels. At trial completion, aerobic training decreased circulating levels of S100B compared with usual care plus education. Furthermore, reduced S100B levels were associated with improved global cognitive function in those who received the aerobic exercise intervention. Together these findings suggest that S100B is a promising target mediating the beneficial effects of moderate-intensity aerobic training on brain health in older adults with mild SIVCI.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Barha CK

Aging, Mobility, and Cognitive Neuroscience Lab, Department of Physical Therapy, University of British Columbia, Vancouver, Canada; Djavad Mowafaghian Centre for Brain Health, Vancouver, Canada; Centre for Hip Health and Mobility, Vancouver, Canada.

Hsiung GYR

Djavad Mowafaghian Centre for Brain Health, Vancouver, Canada; Division of Neurology, University of British Columbia, Vancouver, Canada; Vancouver Coastal Health Research Institute and University of British Columbia Hospital Clinic for Alzheimer Disease and Related Disorders, Vancouver, Canada.

Liu-Ambrose T

MeSH

AgedAged, 80 and overBiomarkersCognitive DysfunctionExerciseExercise TherapyFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsS100 Calcium Binding Protein beta SubunitSingle-Blind MethodTreatment Outcome

Pub Type(s)

Journal Article

Randomized Controlled Trial

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31075314

Clinical Trial Links

Clinical trial which this article describes

Citation

Barha, C K., et al. "The Role of S100B in Aerobic Training Efficacy in Older Adults With Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial." Neuroscience, vol. 410, 2019, pp. 176-182.

Barha CK, Hsiung GYR, Liu-Ambrose T. The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. Neuroscience. 2019;410:176-182.

Barha, C. K., Hsiung, G. Y. R., & Liu-Ambrose, T. (2019). The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. Neuroscience, 410, 176-182. https://doi.org/10.1016/j.neuroscience.2019.04.052

Barha CK, Hsiung GYR, Liu-Ambrose T. The Role of S100B in Aerobic Training Efficacy in Older Adults With Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. Neuroscience. 2019 07 1;410:176-182. PubMed PMID: 31075314.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. AU - Barha,C K, AU - Hsiung,G Y R, AU - Liu-Ambrose,T, Y1 - 2019/05/07/ PY - 2019/01/29/received PY - 2019/04/17/revised PY - 2019/04/26/accepted PY - 2019/5/11/pubmed PY - 2020/2/1/medline PY - 2019/5/11/entrez KW - S100B KW - aging KW - cognition KW - exercise KW - randomized controlled trial KW - vascular cognitive impairment SP - 176 EP - 182 JF - Neuroscience JO - Neuroscience VL - 410 N2 - Aerobic training improves cognitive and brain outcomes across different populations and neurocognitive disorders of aging, including mild subcortical ischemic vascular cognitive impairment (SIVCI). However, little is known of the underlying mechanisms through which aerobic training exerts its beneficial effects on the brain. Recently, S100 calcium-binding protein B (S100B) has been proposed as a possible mediator of aerobic training. Thus we conducted a secondary analysis of data collected from the proof-of-concept single-blind randomized controlled trial (NCT01027858) in older adults with mild SIVCI to determine whether the beneficial effects of 6-months, thrice weekly, moderate-intensity aerobic training on cognitive performance is related to changes in S100B levels. At trial completion, aerobic training decreased circulating levels of S100B compared with usual care plus education. Furthermore, reduced S100B levels were associated with improved global cognitive function in those who received the aerobic exercise intervention. Together these findings suggest that S100B is a promising target mediating the beneficial effects of moderate-intensity aerobic training on brain health in older adults with mild SIVCI. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/31075314/The_Role_of_S100B_in_Aerobic_Training_Efficacy_in_Older_Adults_with_Mild_Vascular_Cognitive_Impairment:_Secondary_Analysis_of_a_Randomized_Controlled_Trial_ DB - PRIME DP - Unbound Medicine ER -

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The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial.Neuroscience. 2019 07 01; 410:176-182.N