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Association of Kidney Transplant Center Volume With 3-Year Clinical Outcomes.

Abstract

RATIONALE & OBJECTIVE

A robust relationship between procedure volume and clinical outcomes has been demonstrated across many surgical fields. This study assessed whether a center volume-outcome relationship exists for contemporary kidney transplantation, specifically for diabetic recipients, older recipients (aged ≥65 years), and recipients of high kidney donor profile index (KDPI ≥ 85) kidneys.

STUDY DESIGN

Retrospective cohort study.

SETTING & PARTICIPANTS

Adult kidney-only transplant recipients who underwent transplantation between 2009 and 2013 (N = 79,581).

EXPOSURES

The primary exposure variable was center volume, categorized into quartiles based on the total kidney transplantation volume. Quartile 1 (Q1) centers performed a mean of fewer than 66 kidney transplantations per year, whereas Q4 centers performed a mean of more than 196 kidney transplantations per year.

OUTCOMES

All-cause graft failure and mortality within 3 years of transplantation.

ANALYTICAL APPROACH

Multivariable Cox frailty models were used to adjust for donor characteristics, recipient characteristics, and cold ischemia time.

RESULTS

Minor differences in rates of 3-year deceased donor all-cause graft failure across quartiles of center volume were observed (14.9% for Q1 vs 16.7% for Q4), including in subgroups (diabetic recipients, 18.4% for Q1 vs 19.7% for Q4; older recipients, 19.4% for Q1 vs 22.5% for Q4; recipients of high KDPI kidneys, 26.5% for Q1 vs 26.5% for Q4). Results were similar for 3-year mortality. After adjustment for donor, recipient, and graft characteristics using Cox regression, center volume was not significantly associated with all-cause graft failure or mortality within 3 years, except that diabetic recipients at Q3 centers had slightly lower mortality (compared with Q1 centers, adjusted HR of 0.85 [95% CI, 0.73-0.99]).

LIMITATIONS

Potential unmeasured confounding from patient comorbid conditions and organ selection.

CONCLUSIONS

These findings provide little evidence that care in higher volume centers is associated with better adjusted outcomes for kidney transplant recipients, even in populations anticipated to be at increased risk for graft failure or death.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Surgery, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; National Clinician Scholars Program, University of Pennsylvania, Philadelphia, PA.

    ,

    Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.

    ,

    Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.

    ,

    Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA.

    ,

    Department of Surgery, University of Pennsylvania, Philadelphia, PA.

    ,

    Department of Surgery, University of Pennsylvania, Philadelphia, PA.

    Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA. Electronic address: peter.reese@uphs.upenn.edu.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31076173

    Citation

    Sonnenberg, Elizabeth M., et al. "Association of Kidney Transplant Center Volume With 3-Year Clinical Outcomes." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 2019.
    Sonnenberg EM, Cohen JB, Hsu JY, et al. Association of Kidney Transplant Center Volume With 3-Year Clinical Outcomes. Am J Kidney Dis. 2019.
    Sonnenberg, E. M., Cohen, J. B., Hsu, J. Y., Potluri, V. S., Levine, M. H., Abt, P. L., & Reese, P. P. (2019). Association of Kidney Transplant Center Volume With 3-Year Clinical Outcomes. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, doi:10.1053/j.ajkd.2019.02.019.
    Sonnenberg EM, et al. Association of Kidney Transplant Center Volume With 3-Year Clinical Outcomes. Am J Kidney Dis. 2019 May 7; PubMed PMID: 31076173.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of Kidney Transplant Center Volume With 3-Year Clinical Outcomes. AU - Sonnenberg,Elizabeth M, AU - Cohen,Jordana B, AU - Hsu,Jesse Y, AU - Potluri,Vishnu S, AU - Levine,Matthew H, AU - Abt,Peter L, AU - Reese,Peter P, Y1 - 2019/05/07/ PY - 2019/01/01/received PY - 2019/02/26/accepted PY - 2019/5/12/entrez PY - 2019/5/12/pubmed PY - 2019/5/12/medline KW - Kidney transplant KW - diabetic transplant recipients KW - end-stage renal disease (ESRD) KW - graft survival KW - older transplant recipients KW - quality of care KW - recipients of high KDPI grafts KW - transplant center volume KW - transplant outcomes KW - transplant referral JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. N2 - RATIONALE & OBJECTIVE: A robust relationship between procedure volume and clinical outcomes has been demonstrated across many surgical fields. This study assessed whether a center volume-outcome relationship exists for contemporary kidney transplantation, specifically for diabetic recipients, older recipients (aged ≥65 years), and recipients of high kidney donor profile index (KDPI ≥ 85) kidneys. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Adult kidney-only transplant recipients who underwent transplantation between 2009 and 2013 (N = 79,581). EXPOSURES: The primary exposure variable was center volume, categorized into quartiles based on the total kidney transplantation volume. Quartile 1 (Q1) centers performed a mean of fewer than 66 kidney transplantations per year, whereas Q4 centers performed a mean of more than 196 kidney transplantations per year. OUTCOMES: All-cause graft failure and mortality within 3 years of transplantation. ANALYTICAL APPROACH: Multivariable Cox frailty models were used to adjust for donor characteristics, recipient characteristics, and cold ischemia time. RESULTS: Minor differences in rates of 3-year deceased donor all-cause graft failure across quartiles of center volume were observed (14.9% for Q1 vs 16.7% for Q4), including in subgroups (diabetic recipients, 18.4% for Q1 vs 19.7% for Q4; older recipients, 19.4% for Q1 vs 22.5% for Q4; recipients of high KDPI kidneys, 26.5% for Q1 vs 26.5% for Q4). Results were similar for 3-year mortality. After adjustment for donor, recipient, and graft characteristics using Cox regression, center volume was not significantly associated with all-cause graft failure or mortality within 3 years, except that diabetic recipients at Q3 centers had slightly lower mortality (compared with Q1 centers, adjusted HR of 0.85 [95% CI, 0.73-0.99]). LIMITATIONS: Potential unmeasured confounding from patient comorbid conditions and organ selection. CONCLUSIONS: These findings provide little evidence that care in higher volume centers is associated with better adjusted outcomes for kidney transplant recipients, even in populations anticipated to be at increased risk for graft failure or death. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/31076173/Association_of_Kidney_Transplant_Center_Volume_With_3-Year_Clinical_Outcomes L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(19)30635-3 DB - PRIME DP - Unbound Medicine ER -