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Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl.
Forensic Sci Int. 2019 Jul; 300:75-81.FS

Abstract

In 2017, 47,600 overdose deaths were reported to be associated with the abuse of opioids, including prescription painkillers (e.g. oxycodone), opiates (e.g. heroin), or synthetic opioids (e.g. fentanyl) within the United States. The recent spike in the presence of synthetic opioids in lots of heroin distributed on the street present specific and significant challenges to law enforcement. Synthetic opioids are extremely toxic substances, which can easily be inhaled. This type of exposure can lead to accidental overdoses by law enforcement and other first responders answering calls involving illicit drugs containing these substances. Due to this extreme toxicity, it is important for these individuals to have tools that can be easily deployed for accurate presumptive field tests. Currently, there are only a limited number of presumptive tests available for fentanyl detection. In this study, we addressed this technology gap by evaluating newly developed lateral flow immunoassays (LFIs) designed for the detection of fentanyl and its derivatives. These LFIs were evaluated for effectiveness in different biofluid matrices, following an in vivo exposure, cross-reactivity with fentanyl analogs, and in case samples. This study demonstrates that LFIs have the potential to be used by law enforcement for the detection of synthetic opioids.

Authors+Show Affiliations

U.S. Army, Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, MD, USA. Electronic address: daniel.j.angelini2.civ@mail.mil.U.S. Army, Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, MD, USA.Excet, Inc., Springfield, VA, USA.U.S. Army, Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, MD, USA.National Institute of Standards & Technology, Materials Measurement Science Division, Gaithersburg, MD, USA.U.S. Army, Combat Capabilities Development Command Chemical Biological Center, Aberdeen Proving Ground, MD, USA.

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

31078080

Citation

Angelini, Daniel J., et al. "Evaluation of a Lateral Flow Immunoassay for the Detection of the Synthetic Opioid Fentanyl." Forensic Science International, vol. 300, 2019, pp. 75-81.
Angelini DJ, Biggs TD, Maughan MN, et al. Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl. Forensic Sci Int. 2019;300:75-81.
Angelini, D. J., Biggs, T. D., Maughan, M. N., Feasel, M. G., Sisco, E., & Sekowski, J. W. (2019). Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl. Forensic Science International, 300, 75-81. https://doi.org/10.1016/j.forsciint.2019.04.019
Angelini DJ, et al. Evaluation of a Lateral Flow Immunoassay for the Detection of the Synthetic Opioid Fentanyl. Forensic Sci Int. 2019;300:75-81. PubMed PMID: 31078080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl. AU - Angelini,Daniel J, AU - Biggs,Tracey D, AU - Maughan,Michele N, AU - Feasel,Michael G, AU - Sisco,Edward, AU - Sekowski,Jennifer W, Y1 - 2019/04/26/ PY - 2019/01/08/received PY - 2019/04/10/revised PY - 2019/04/17/accepted PY - 2019/5/12/pubmed PY - 2019/6/18/medline PY - 2019/5/12/entrez KW - Detection KW - Fentanyl KW - Forensic science KW - Illicit drug KW - Lateral flow immunoassay KW - Opioid SP - 75 EP - 81 JF - Forensic science international JO - Forensic Sci Int VL - 300 N2 - In 2017, 47,600 overdose deaths were reported to be associated with the abuse of opioids, including prescription painkillers (e.g. oxycodone), opiates (e.g. heroin), or synthetic opioids (e.g. fentanyl) within the United States. The recent spike in the presence of synthetic opioids in lots of heroin distributed on the street present specific and significant challenges to law enforcement. Synthetic opioids are extremely toxic substances, which can easily be inhaled. This type of exposure can lead to accidental overdoses by law enforcement and other first responders answering calls involving illicit drugs containing these substances. Due to this extreme toxicity, it is important for these individuals to have tools that can be easily deployed for accurate presumptive field tests. Currently, there are only a limited number of presumptive tests available for fentanyl detection. In this study, we addressed this technology gap by evaluating newly developed lateral flow immunoassays (LFIs) designed for the detection of fentanyl and its derivatives. These LFIs were evaluated for effectiveness in different biofluid matrices, following an in vivo exposure, cross-reactivity with fentanyl analogs, and in case samples. This study demonstrates that LFIs have the potential to be used by law enforcement for the detection of synthetic opioids. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/31078080/Evaluation_of_a_lateral_flow_immunoassay_for_the_detection_of_the_synthetic_opioid_fentanyl_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(19)30153-7 DB - PRIME DP - Unbound Medicine ER -