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Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Dec; 128(6):e208-e213.OS

Abstract

Epidermolytic acanthoma represents a rare localized form of epidermolytic hyperkeratosis, which resembles warty lesions and shows a strong predilection for the genital skin of males. Here, we present an oral solitary epidermolytic acanthoma affecting a 71-year-old Caucasian man. Clinically, the lesion was white, well-circumscribed, and sessile, measuring 2 mm in diameter and located on the posterior mandibular buccal gingiva. Microscopically, pronounced hyperkeratosis and acanthosis, with formation of keratin crypts was observed. Lesional cells of the spinous and granular epithelial layers exhibited prominent intracellular vacuolar degeneration, as well as eosinophilic paranuclear and perinuclear condensations. Intracytoplasmic eosinophilic globules were also seen. No recurrences have been reported. Investigation for low- and high-risk human papillomavirus (HPV) infection failed to reveal positivity for HPV subtypes 6, 11, 16, and 18. Literature review revealed scarce reports of epidermolytic hyperkeratosis-like changes of the oral mucosa associated with malignant neoplasms and inflammatory processes. Epidermolytic acanthoma should be considered in the differential diagnosis of benign epithelial papillomatous lesions of the oral cavity.

Authors+Show Affiliations

Postdoctoral Associate, Department of Biochemistry, Molecular Biology, and Biophysics, College of Biological Sciences, and Division of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA. Electronic address: Argyr005@umn.edu.Dental Student, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.Assistant Professor, Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.Associate Professor, Department of Diagnostic and Biological Sciences, Division of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31078506

Citation

Argyris, Prokopios P., et al. "Solitary Oral Epidermolytic Acanthoma: Case Report of a Rarely Diagnosed Entity." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 128, no. 6, 2019, pp. e208-e213.
Argyris PP, Slama ZM, Nelson AC, et al. Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128(6):e208-e213.
Argyris, P. P., Slama, Z. M., Nelson, A. C., & Koutlas, I. G. (2019). Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 128(6), e208-e213. https://doi.org/10.1016/j.oooo.2019.03.016
Argyris PP, et al. Solitary Oral Epidermolytic Acanthoma: Case Report of a Rarely Diagnosed Entity. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128(6):e208-e213. PubMed PMID: 31078506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. AU - Argyris,Prokopios P, AU - Slama,Zachary M, AU - Nelson,Andrew C, AU - Koutlas,Ioannis G, Y1 - 2019/03/31/ PY - 2018/10/22/received PY - 2019/02/19/revised PY - 2019/03/19/accepted PY - 2019/5/13/pubmed PY - 2019/5/13/medline PY - 2019/5/13/entrez SP - e208 EP - e213 JF - Oral surgery, oral medicine, oral pathology and oral radiology JO - Oral Surg Oral Med Oral Pathol Oral Radiol VL - 128 IS - 6 N2 - Epidermolytic acanthoma represents a rare localized form of epidermolytic hyperkeratosis, which resembles warty lesions and shows a strong predilection for the genital skin of males. Here, we present an oral solitary epidermolytic acanthoma affecting a 71-year-old Caucasian man. Clinically, the lesion was white, well-circumscribed, and sessile, measuring 2 mm in diameter and located on the posterior mandibular buccal gingiva. Microscopically, pronounced hyperkeratosis and acanthosis, with formation of keratin crypts was observed. Lesional cells of the spinous and granular epithelial layers exhibited prominent intracellular vacuolar degeneration, as well as eosinophilic paranuclear and perinuclear condensations. Intracytoplasmic eosinophilic globules were also seen. No recurrences have been reported. Investigation for low- and high-risk human papillomavirus (HPV) infection failed to reveal positivity for HPV subtypes 6, 11, 16, and 18. Literature review revealed scarce reports of epidermolytic hyperkeratosis-like changes of the oral mucosa associated with malignant neoplasms and inflammatory processes. Epidermolytic acanthoma should be considered in the differential diagnosis of benign epithelial papillomatous lesions of the oral cavity. SN - 2212-4411 UR - https://www.unboundmedicine.com/medline/citation/31078506/Solitary_oral_epidermolytic_acanthoma:_Case_report_of_a_rarely_diagnosed_entity L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-4403(19)30437-7 DB - PRIME DP - Unbound Medicine ER -