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Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice.

Abstract

Refractory wound healing is one of the most common complications of diabetes. Excessive production of reactive oxygen species (ROS) can cause chronic inflammation and thus impair cutaneous wound healing. Scavenging these ROS in wound dressing may offer effective treatment for chronic wounds. Here, a nanocomposite hydrogel based on alginate and positively charged Eudragit nanoparticles containing edaravone, an efficient free radical scavenger, was developed for maximal ROS sequestration. Eudragit nanoparticles enhanced edaravone solubility and stability breaking the limitations in application. Furthermore, loading these Eudragit nanoparticles into an alginate hydrogel increased the protection and sustained the release of edaravone. The nanocomposite hydrogel is shown to promote wound healing in a dose-dependent way. A low dose of edaravone-loaded nanocomposite hydrogel accelerated wound healing in diabetic mice. On the contrary, a high dose of edaravone might hamper the healing. Those results indicated the dual role of ROS in chronic wounds. In addition, the discovery of this work pointed out that dose could be the key factor limiting the translational application of antioxidants in wound healing.

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  • Authors+Show Affiliations

    ,

    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. fanying@cqu.edu.cn.

    ,

    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. wuwen1988@cqu.edu.cn.

    ,

    School of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqiang 401331, China. backer7_leiyu@163.com.

    ,

    Faculté de pharmacé, Université de Lorraine, CITHEFOR F-54000 Nancy CEDEX, France. caroline.gaucher@univ-lorraine.fr.

    ,

    School of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqiang 401331, China. peishuchen928@163.com.

    ,

    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. j.zhang1983@cqu.edu.cn.

    Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. xxia@cqu.edu.cn.

    Source

    Marine drugs 17:5 2019 May 11 pg

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31083588

    Citation

    Fan, Ying, et al. "Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice." Marine Drugs, vol. 17, no. 5, 2019.
    Fan Y, Wu W, Lei Y, et al. Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice. Mar Drugs. 2019;17(5).
    Fan, Y., Wu, W., Lei, Y., Gaucher, C., Pei, S., Zhang, J., & Xia, X. (2019). Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice. Marine Drugs, 17(5), doi:10.3390/md17050285.
    Fan Y, et al. Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice. Mar Drugs. 2019 May 11;17(5) PubMed PMID: 31083588.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Edaravone-Loaded Alginate-Based Nanocomposite Hydrogel Accelerated Chronic Wound Healing in Diabetic Mice. AU - Fan,Ying, AU - Wu,Wen, AU - Lei,Yu, AU - Gaucher,Caroline, AU - Pei,Shuchen, AU - Zhang,Jinqiang, AU - Xia,Xuefeng, Y1 - 2019/05/11/ PY - 2019/04/10/received PY - 2019/04/30/revised PY - 2019/05/08/accepted PY - 2019/5/15/entrez PY - 2019/5/15/pubmed PY - 2019/5/15/medline KW - chronic wounds KW - edaravone KW - nanocomposite alginate hydrogel KW - oxidative stress KW - reactive oxygen species JF - Marine drugs JO - Mar Drugs VL - 17 IS - 5 N2 - Refractory wound healing is one of the most common complications of diabetes. Excessive production of reactive oxygen species (ROS) can cause chronic inflammation and thus impair cutaneous wound healing. Scavenging these ROS in wound dressing may offer effective treatment for chronic wounds. Here, a nanocomposite hydrogel based on alginate and positively charged Eudragit nanoparticles containing edaravone, an efficient free radical scavenger, was developed for maximal ROS sequestration. Eudragit nanoparticles enhanced edaravone solubility and stability breaking the limitations in application. Furthermore, loading these Eudragit nanoparticles into an alginate hydrogel increased the protection and sustained the release of edaravone. The nanocomposite hydrogel is shown to promote wound healing in a dose-dependent way. A low dose of edaravone-loaded nanocomposite hydrogel accelerated wound healing in diabetic mice. On the contrary, a high dose of edaravone might hamper the healing. Those results indicated the dual role of ROS in chronic wounds. In addition, the discovery of this work pointed out that dose could be the key factor limiting the translational application of antioxidants in wound healing. SN - 1660-3397 UR - https://www.unboundmedicine.com/medline/citation/31083588/Edaravone-Loaded_Alginate-Based_Nanocomposite_Hydrogel_Accelerated_Chronic_Wound_Healing_in_Diabetic_Mice L2 - http://www.mdpi.com/resolver?pii=md17050285 DB - PRIME DP - Unbound Medicine ER -