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Iron deficiency, still a rarity in children with sickle cell anemia in Ile-Ife, Nigeria.

Abstract

In this study, children with sickle cell anemia were evaluated for iron deficiency. Serum ferritin and free erythrocyte protoporphyrin free erythrocyte protoporphyrin (FEP) levels, mean corpuscular volume mean corpuscular volume (MCV) and mean corpuscular hemoglobin mean corpuscular hemoglobin (MCH) were used in determining their iron status. The study was done at Pediatric Hematology Outpatient Clinic of the Obafemi Awolowo University Teaching Hospitals' Complex, Ile-Ife. Forty-eight HbSS subjects in steady state and 48 apparently well age and sex matched HbAA controls were evaluated. Serum ferritin less than 25ng/dL FEP greater than cut off for age, mean corpuscular volume MCV and mean corpuscular hemoglobin MCH less than cut off for age were regarded as indicating iron deficiency. Serum ferritin values ranged from 34.2 to 3282.9μg/L, with a mean of 381.2 (1.0), median 180μg/L; which was significantly higher than the controls (p=0.000). FEP was lower in the subjects but none was iron deficient compared with the controls. The mean corpuscular hemoglobin MCH of subjects was significantly lower than the controls. Subjects had lower mean corpuscular volume MCV compared with controls. Iron deficiency was not detected in any of the subjects with sickle cell anemia in comparison to a prevalence of 43.75% in the controls. Iron deficiency anemia (IDA) was found in 16.7% of the controls, using the WHO cut off for anemia which is hemoglobin concentration of <11g/dl. While a high prevalence of iron deficiency was noted in the control group, patients with sickle cell anemia were largely iron sufficient, despite their anemia. Iron supplementation remains unnecessary as part of routine management of children with sickle cell anemia in our practice.

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  • Authors+Show Affiliations

    ,

    University of Medical Sciences, Ondo, Nigeria. Electronic address: drolufunky@gmail.com.

    ,

    Obafemi Awolowo University, Ile-Ife, Nigeria.

    ,

    Obafemi Awolowo University, Ile-Ife, Nigeria.

    Obafemi Awolowo University, Ile-Ife, Nigeria.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31085147

    Citation

    Odunlade, Olufunke, et al. "Iron Deficiency, Still a Rarity in Children With Sickle Cell Anemia in Ile-Ife, Nigeria." Hematology, Transfusion and Cell Therapy, 2019.
    Odunlade O, Adeodu O, Owa J, et al. Iron deficiency, still a rarity in children with sickle cell anemia in Ile-Ife, Nigeria. Hematol Transfus Cell Ther. 2019.
    Odunlade, O., Adeodu, O., Owa, J., & Obuotor, E. (2019). Iron deficiency, still a rarity in children with sickle cell anemia in Ile-Ife, Nigeria. Hematology, Transfusion and Cell Therapy, doi:10.1016/j.htct.2018.11.006.
    Odunlade O, et al. Iron Deficiency, Still a Rarity in Children With Sickle Cell Anemia in Ile-Ife, Nigeria. Hematol Transfus Cell Ther. 2019 Mar 28; PubMed PMID: 31085147.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Iron deficiency, still a rarity in children with sickle cell anemia in Ile-Ife, Nigeria. AU - Odunlade,Olufunke, AU - Adeodu,Olugbenga, AU - Owa,Joshua, AU - Obuotor,Efere, Y1 - 2019/03/28/ PY - 2018/07/18/received PY - 2018/10/29/revised PY - 2018/11/12/accepted PY - 2019/5/16/entrez KW - Free erythrocyte protoporphyrin KW - Iron deficiency KW - Iron deficiency anemia KW - Serum ferritin KW - Sickle cell anemia JF - Hematology, transfusion and cell therapy JO - Hematol Transfus Cell Ther N2 - In this study, children with sickle cell anemia were evaluated for iron deficiency. Serum ferritin and free erythrocyte protoporphyrin free erythrocyte protoporphyrin (FEP) levels, mean corpuscular volume mean corpuscular volume (MCV) and mean corpuscular hemoglobin mean corpuscular hemoglobin (MCH) were used in determining their iron status. The study was done at Pediatric Hematology Outpatient Clinic of the Obafemi Awolowo University Teaching Hospitals' Complex, Ile-Ife. Forty-eight HbSS subjects in steady state and 48 apparently well age and sex matched HbAA controls were evaluated. Serum ferritin less than 25ng/dL FEP greater than cut off for age, mean corpuscular volume MCV and mean corpuscular hemoglobin MCH less than cut off for age were regarded as indicating iron deficiency. Serum ferritin values ranged from 34.2 to 3282.9μg/L, with a mean of 381.2 (1.0), median 180μg/L; which was significantly higher than the controls (p=0.000). FEP was lower in the subjects but none was iron deficient compared with the controls. The mean corpuscular hemoglobin MCH of subjects was significantly lower than the controls. Subjects had lower mean corpuscular volume MCV compared with controls. Iron deficiency was not detected in any of the subjects with sickle cell anemia in comparison to a prevalence of 43.75% in the controls. Iron deficiency anemia (IDA) was found in 16.7% of the controls, using the WHO cut off for anemia which is hemoglobin concentration of <11g/dl. While a high prevalence of iron deficiency was noted in the control group, patients with sickle cell anemia were largely iron sufficient, despite their anemia. Iron supplementation remains unnecessary as part of routine management of children with sickle cell anemia in our practice. SN - 2531-1387 UR - https://www.unboundmedicine.com/medline/citation/31085147/Iron_deficiency,_still_a_rarity_in_children_with_sickle_cell_anemia_in_Ile-Ife,_Nigeria L2 - https://linkinghub.elsevier.com/retrieve/pii/S2531-1379(19)30029-X DB - PRIME DP - Unbound Medicine ER -