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A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents.

Abstract

Chrysin belongs to the flavonoids and has been used as traditional medicine from ancient and has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepato- and nephroprotective activities of chrysin were discussed in this review. Chrysin exhibited hepatoprotective activity against 2,3,7,8-tetrachlorodibenzo-p-dioxin, carbon tetrachloride, cisplatin, d-galactosamine, doxorubicin, ethanol, lipopolysaccharide/d-galactosamine, methotrexate, ammonium chloride, paracetamol, diethylnitrosamine, streptozotocin, tert-butyl hydroperoxide, thioacetamide, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP), ischemia/reperfusion-induced hepatotoxicity and nephroprotective activity against cisplatin, doxorubicin, paracetamol, gentamicin, streptazotocin, N-nitrosodiethyl amine, 5-fluorouracil, adenine, carbon tetrachloride, copper, 2,3,7,8-tetrachlorodibenzo- p-dioxin, colistin, Nω-nitro-l-arginine-methylester and ethanol in various animal models due to its antioxidant, anti-apoptotic activities. In this review, we provide an overview of the possible mechanisms by which chrysin reduced the hepatotoxicity and nephrotoxicity of different toxicants. This will help the toxicologists, pharmacologists and chemists to develop new safer pharmaceutical products with chrysin and other toxicants.

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  • Authors+Show Affiliations

    ,

    Research and Development, Department of Pharmacy, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India; Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India. Electronic address: ravindrapingili@gmail.com.

    ,

    Department of Pharmaceutical Analysis, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India.

    ,

    Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.

    ,

    Department of Pharmacy Practice, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.

    ,

    Department of Pharmacy Practice, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.

    Department of Pharmacy Practice, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.

    Source

    Chemico-biological interactions 308: 2019 May 11 pg 51-60

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    31085170

    Citation

    Pingili, Ravindra Babu, et al. "A Comprehensive Review On Hepatoprotective and Nephroprotective Activities of Chrysin Against Various Drugs and Toxic Agents." Chemico-biological Interactions, vol. 308, 2019, pp. 51-60.
    Pingili RB, Pawar AK, Challa SR, et al. A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents. Chem Biol Interact. 2019;308:51-60.
    Pingili, R. B., Pawar, A. K., Challa, S. R., Kodali, T., Koppula, S., & Toleti, V. (2019). A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents. Chemico-biological Interactions, 308, pp. 51-60. doi:10.1016/j.cbi.2019.05.010.
    Pingili RB, et al. A Comprehensive Review On Hepatoprotective and Nephroprotective Activities of Chrysin Against Various Drugs and Toxic Agents. Chem Biol Interact. 2019 May 11;308:51-60. PubMed PMID: 31085170.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents. AU - Pingili,Ravindra Babu, AU - Pawar,A Krishnamanjari, AU - Challa,Siva Reddy, AU - Kodali,Tanvija, AU - Koppula,Sirisha, AU - Toleti,Vyshnavi, Y1 - 2019/05/11/ PY - 2019/03/17/received PY - 2019/05/06/accepted PY - 2019/5/16/pubmed PY - 2019/5/16/medline PY - 2019/5/16/entrez KW - Antioxidant KW - Chrysin KW - Flavonoids KW - Hepatoprotective KW - Hepatotoxicants KW - Nephroprotective SP - 51 EP - 60 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 308 N2 - Chrysin belongs to the flavonoids and has been used as traditional medicine from ancient and has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepato- and nephroprotective activities of chrysin were discussed in this review. Chrysin exhibited hepatoprotective activity against 2,3,7,8-tetrachlorodibenzo-p-dioxin, carbon tetrachloride, cisplatin, d-galactosamine, doxorubicin, ethanol, lipopolysaccharide/d-galactosamine, methotrexate, ammonium chloride, paracetamol, diethylnitrosamine, streptozotocin, tert-butyl hydroperoxide, thioacetamide, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP), ischemia/reperfusion-induced hepatotoxicity and nephroprotective activity against cisplatin, doxorubicin, paracetamol, gentamicin, streptazotocin, N-nitrosodiethyl amine, 5-fluorouracil, adenine, carbon tetrachloride, copper, 2,3,7,8-tetrachlorodibenzo- p-dioxin, colistin, Nω-nitro-l-arginine-methylester and ethanol in various animal models due to its antioxidant, anti-apoptotic activities. In this review, we provide an overview of the possible mechanisms by which chrysin reduced the hepatotoxicity and nephrotoxicity of different toxicants. This will help the toxicologists, pharmacologists and chemists to develop new safer pharmaceutical products with chrysin and other toxicants. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/31085170/A_comprehensive_review_on_hepatoprotective_and_nephroprotective_activities_of_chrysin_against_various_drugs_and_toxic_agents L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(19)30466-1 DB - PRIME DP - Unbound Medicine ER -