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Miltefosine Induced Reduced Male Fertility Capacity after Treatment of Post Kala-azar Dermal Leishmaniasis, Bangladesh.
Mymensingh Med J. 2019 Apr; 28(2):328-332.MM

Abstract

Post Kala-azar Dermal Leishmaniasis (PKDL) is the sequel of visceral leishmaniasis in Indian subcontinent and may appear among patients with or without previous history of visceral leishmaniasis (VL). The aim of the study is to understand the male reproductive safety profile of miltefosine used for the treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in Bangladesh. From January 2017 to March 2017, an exploratory study was carried out on male fertility capacity in Bangladesh among male patients above 14 years old with PKDL treated with miltefosine. Twenty nine male patients were included to observe the effect of miltefosine on reproductive health. All PKDL patients had history of visceral leishmaniasis (VL) in different time periods. Among them three (10.3%) patients were unable to ejaculate semen. In semen analysis, 3 patients (10.3%) were found azoospermia (sperm count & motility- 0, viscosity- good, pH- 7 to 8), microscopically there was presence of RBC (5-15/HPF), WBC (8-15/HPF). Another 3 patients (10.3%) were found oligospermia (sperm count- 4.2 to 15.3 million/ml, motility- 20 to 50%, viscosity- good, pH- 6 to 9, RBC- 4 to 15/HPF, WBC- 4 to 15/HPF). The study documented some important findings in evaluating male infertility and selection of drug regimens in treating PKDL patients with miltefosine for 12 weeks.

Authors+Show Affiliations

Dr Ariful Basher, Registrar, Infectious and Tropical Medicine, Mymensingh Medical College & Hospital (MMCH), Mymensingh, Bangladesh; E-mail: arifulbasher@yahoo.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31086147

Citation

Basher, A, et al. "Miltefosine Induced Reduced Male Fertility Capacity After Treatment of Post Kala-azar Dermal Leishmaniasis, Bangladesh." Mymensingh Medical Journal : MMJ, vol. 28, no. 2, 2019, pp. 328-332.
Basher A, Rashid MM, Habibullah AM, et al. Miltefosine Induced Reduced Male Fertility Capacity after Treatment of Post Kala-azar Dermal Leishmaniasis, Bangladesh. Mymensingh Med J. 2019;28(2):328-332.
Basher, A., Rashid, M. M., Habibullah, A. M., Nath, R., Akter, D., Chowdhury, I. H., Azim, A., Nath, P., & Faiz, M. A. (2019). Miltefosine Induced Reduced Male Fertility Capacity after Treatment of Post Kala-azar Dermal Leishmaniasis, Bangladesh. Mymensingh Medical Journal : MMJ, 28(2), 328-332.
Basher A, et al. Miltefosine Induced Reduced Male Fertility Capacity After Treatment of Post Kala-azar Dermal Leishmaniasis, Bangladesh. Mymensingh Med J. 2019;28(2):328-332. PubMed PMID: 31086147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Miltefosine Induced Reduced Male Fertility Capacity after Treatment of Post Kala-azar Dermal Leishmaniasis, Bangladesh. AU - Basher,A, AU - Rashid,M M, AU - Habibullah,A M, AU - Nath,R, AU - Akter,D, AU - Chowdhury,I H, AU - Azim,A, AU - Nath,P, AU - Faiz,M A, PY - 2019/5/16/entrez PY - 2019/5/16/pubmed PY - 2019/9/7/medline SP - 328 EP - 332 JF - Mymensingh medical journal : MMJ JO - Mymensingh Med J VL - 28 IS - 2 N2 - Post Kala-azar Dermal Leishmaniasis (PKDL) is the sequel of visceral leishmaniasis in Indian subcontinent and may appear among patients with or without previous history of visceral leishmaniasis (VL). The aim of the study is to understand the male reproductive safety profile of miltefosine used for the treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in Bangladesh. From January 2017 to March 2017, an exploratory study was carried out on male fertility capacity in Bangladesh among male patients above 14 years old with PKDL treated with miltefosine. Twenty nine male patients were included to observe the effect of miltefosine on reproductive health. All PKDL patients had history of visceral leishmaniasis (VL) in different time periods. Among them three (10.3%) patients were unable to ejaculate semen. In semen analysis, 3 patients (10.3%) were found azoospermia (sperm count & motility- 0, viscosity- good, pH- 7 to 8), microscopically there was presence of RBC (5-15/HPF), WBC (8-15/HPF). Another 3 patients (10.3%) were found oligospermia (sperm count- 4.2 to 15.3 million/ml, motility- 20 to 50%, viscosity- good, pH- 6 to 9, RBC- 4 to 15/HPF, WBC- 4 to 15/HPF). The study documented some important findings in evaluating male infertility and selection of drug regimens in treating PKDL patients with miltefosine for 12 weeks. SN - 2408-8757 UR - https://www.unboundmedicine.com/medline/citation/31086147/Miltefosine_Induced_Reduced_Male_Fertility_Capacity_after_Treatment_of_Post_Kala_azar_Dermal_Leishmaniasis_Bangladesh_ L2 - http://www.diseaseinfosearch.org/result/4166 DB - PRIME DP - Unbound Medicine ER -