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Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia.

Abstract

Objective

Iron Deficiency Anemia (IDA) is common nutritional deficiency particularly in women and also common during the older age. Aging increases plasma levels of inflammatory mediators such as pro-inflammatory cytokines and acute phase proteins. However, there is little information about changes in antimicrobial proteins in elderly women with IDA. In this study, we aimed to determine the changes in pro-inflammatory cytokines and newly discovered antimicrobial proteins like hepcidin, chemerin and defensin in elderly women with IDA.

Methods

Blood samples taken from healthy 20 women (55±7 years old) and 20 women with iron deficiency anemia (58±6) were used as material of the study that came to the Cankiri State Hospital in 2016 and 2017 years.

Results

In the study, plasma C-Reactive Protein (CRP) (P <0.01), tumour necrosis factor-α (TNF-α) (P <0.05) and interleukin-6 (IL-6) levels (P <0.05) were significantly increased in group with IDA when compared with healthy group. Also plasma hepcidin (P <0.001), chemerin (P <0.05) and defensin levels (P <0.05) were determined significantly higher than the healthy group.

Conclusion

We found that inflammatory changes occur in elderly women with IDA. Besides pro-inflammatory cytokine levels (CRP, IL-6, TNF-α), antimicrobial protein levels (hepcidin, chemerin, defensin) were found higher in elderly women with IDA because of inflammatory changes.

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  • Authors+Show Affiliations

    ,

    Sinasi Askar Assistant Professor, Department of Nutrition and Dietetics, Cankiri Karatekin University, Cankiri, Turkey.

    ,

    Seyma Nur Deveboynu Res Assistant, Department of Nutrition and Dietetics, Cankiri Karatekin University, Cankiri, Turkey.

    ,

    Hilal ER Res Assistant, Department of Nutrition and Dietetics, Cankiri Karatekin University, Cankiri, Turkey.

    ,

    Prof. Dr. Tunay Kontas Askar Department of Nutrition and Dietetics, Cankiri Karatekin University, Cankiri, Turkey.

    Adnan Adil Hismiogullari Associate Professor, Tibbi Biyokimya Bolumu, Tip Fakultesi, Balikesir Universitesi, Balikesir, Turkey.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31086504

    Citation

    Askar, Sinasi, et al. "Changes in Pro-inflammatory Cytokines and Antimicrobial Proteins in Elderly Women With Iron Deficiency Anemia." Pakistan Journal of Medical Sciences, vol. 35, no. 2, 2019, pp. 298-301.
    Askar S, Deveboynu SN, Er H, et al. Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia. Pak J Med Sci. 2019;35(2):298-301.
    Askar, S., Deveboynu, S. N., Er, H., Askar, T. K., & Hismiogullari, A. A. (2019). Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia. Pakistan Journal of Medical Sciences, 35(2), pp. 298-301. doi:10.12669/pjms.35.2.520.
    Askar S, et al. Changes in Pro-inflammatory Cytokines and Antimicrobial Proteins in Elderly Women With Iron Deficiency Anemia. Pak J Med Sci. 2019;35(2):298-301. PubMed PMID: 31086504.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Changes in pro-inflammatory cytokines and antimicrobial proteins in elderly women with iron deficiency anemia. AU - Askar,Sinasi, AU - Deveboynu,Seyma Nur, AU - Er,Hilal, AU - Askar,Tunay Kontas, AU - Hismiogullari,Adnan Adil, PY - 2019/5/16/entrez PY - 2019/5/16/pubmed PY - 2019/5/16/medline KW - Antimicrobial protein KW - Cytokines KW - Iron deficiency anemia SP - 298 EP - 301 JF - Pakistan journal of medical sciences JO - Pak J Med Sci VL - 35 IS - 2 N2 - Objective: Iron Deficiency Anemia (IDA) is common nutritional deficiency particularly in women and also common during the older age. Aging increases plasma levels of inflammatory mediators such as pro-inflammatory cytokines and acute phase proteins. However, there is little information about changes in antimicrobial proteins in elderly women with IDA. In this study, we aimed to determine the changes in pro-inflammatory cytokines and newly discovered antimicrobial proteins like hepcidin, chemerin and defensin in elderly women with IDA. Methods: Blood samples taken from healthy 20 women (55±7 years old) and 20 women with iron deficiency anemia (58±6) were used as material of the study that came to the Cankiri State Hospital in 2016 and 2017 years. Results: In the study, plasma C-Reactive Protein (CRP) (P <0.01), tumour necrosis factor-α (TNF-α) (P <0.05) and interleukin-6 (IL-6) levels (P <0.05) were significantly increased in group with IDA when compared with healthy group. Also plasma hepcidin (P <0.001), chemerin (P <0.05) and defensin levels (P <0.05) were determined significantly higher than the healthy group. Conclusion: We found that inflammatory changes occur in elderly women with IDA. Besides pro-inflammatory cytokine levels (CRP, IL-6, TNF-α), antimicrobial protein levels (hepcidin, chemerin, defensin) were found higher in elderly women with IDA because of inflammatory changes. SN - 1682-024X UR - https://www.unboundmedicine.com/medline/citation/31086504/Changes_in_pro-inflammatory_cytokines_and_antimicrobial_proteins_in_elderly_women_with_iron_deficiency_anemia L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31086504/ DB - PRIME DP - Unbound Medicine ER -