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Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018.
Euro Surveill 2019; 24(19)ES

Abstract

In December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing Klebsiella pneumoniae strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with blaKPC-2-producing K. pneumoniae ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site.

Authors+Show Affiliations

Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland.Kuopio University Hospital, Unit of Infections and Hospital hygiene, Kuopio University Hospital, Kuopio, Finland.Eastern Finland laboratory Centre, Kuopio, Finland.Aalto University, Department of Computer Science, Espoo, Finland.Department of Biostatistics, University of Oslo, Oslo, Norway. Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland.Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland.Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31088601

Citation

Räisänen, Kati, et al. "Emergence of Ceftazidime-avibactam-resistant Klebsiella Pneumoniae During Treatment, Finland, December 2018." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 24, no. 19, 2019.
Räisänen K, Koivula I, Ilmavirta H, et al. Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018. Euro Surveill. 2019;24(19).
Räisänen, K., Koivula, I., Ilmavirta, H., Puranen, S., Kallonen, T., Lyytikäinen, O., & Jalava, J. (2019). Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 24(19), doi:10.2807/1560-7917.ES.2019.24.19.1900256.
Räisänen K, et al. Emergence of Ceftazidime-avibactam-resistant Klebsiella Pneumoniae During Treatment, Finland, December 2018. Euro Surveill. 2019;24(19) PubMed PMID: 31088601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018. AU - Räisänen,Kati, AU - Koivula,Irma, AU - Ilmavirta,Heikki, AU - Puranen,Santeri, AU - Kallonen,Teemu, AU - Lyytikäinen,Outi, AU - Jalava,Jari, PY - 2019/5/16/entrez PY - 2019/5/16/pubmed PY - 2019/5/16/medline KW - Klebsiella pneumoniae KW - carbapenem KW - ceftazidime-avibactam KW - resistance KW - whole-genome sequencing, KPC-2 JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill. VL - 24 IS - 19 N2 - In December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing Klebsiella pneumoniae strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with blaKPC-2-producing K. pneumoniae ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/31088601/Emergence_of_ceftazidime_avibactam_resistant_Klebsiella_pneumoniae_during_treatment_Finland_December_2018_ L2 - http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.19.1900256 DB - PRIME DP - Unbound Medicine ER -