Citation
Bernard-Stoecklin, Sibylle, et al. "Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) From 2015 to 2017." Scientific Reports, vol. 9, no. 1, 2019, p. 7385.
Bernard-Stoecklin S, Nikolay B, Assiri A, et al. Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017. Sci Rep. 2019;9(1):7385.
Bernard-Stoecklin, S., Nikolay, B., Assiri, A., Bin Saeed, A. A., Ben Embarek, P. K., El Bushra, H., Ki, M., Malik, M. R., Fontanet, A., Cauchemez, S., & Van Kerkhove, M. D. (2019). Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017. Scientific Reports, 9(1), 7385. https://doi.org/10.1038/s41598-019-43586-9
Bernard-Stoecklin S, et al. Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) From 2015 to 2017. Sci Rep. 2019 05 14;9(1):7385. PubMed PMID: 31089148.
TY - JOUR
T1 - Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017.
AU - Bernard-Stoecklin,Sibylle,
AU - Nikolay,Birgit,
AU - Assiri,Abdullah,
AU - Bin Saeed,Abdul Aziz,
AU - Ben Embarek,Peter Karim,
AU - El Bushra,Hassan,
AU - Ki,Moran,
AU - Malik,Mamunur Rahman,
AU - Fontanet,Arnaud,
AU - Cauchemez,Simon,
AU - Van Kerkhove,Maria D,
Y1 - 2019/05/14/
PY - 2018/11/11/received
PY - 2019/04/18/accepted
PY - 2019/5/16/entrez
PY - 2019/5/16/pubmed
PY - 2020/10/22/medline
SP - 7385
EP - 7385
JF - Scientific reports
JO - Sci Rep
VL - 9
IS - 1
N2 - Since its emergence in 2012, 2,260 cases and 803 deaths due to Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization. Most cases were due to transmission in healthcare settings, sometimes causing large outbreaks. We analyzed epidemiologic and clinical data of laboratory-confirmed MERS-CoV cases from eleven healthcare-associated outbreaks in the Kingdom of Saudi Arabia and the Republic of Korea between 2015-2017. We quantified key epidemiological differences between outbreaks. Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. In multivariate analyses, age ≥65 (OR 4.8, 95%CI: 2.6-8.7) and the presence of underlying comorbidities (OR: 2.7, 95% CI: 1.3-5.7) were associated with increased mortality whereas working as healthcare personnel was protective (OR 0.07, 95% CI: 0.01-0.34). At the start of these outbreaks, the reproduction number ranged from 1.0 to 5.7; it dropped below 1 within 2 to 6 weeks. This study provides a comprehensive characterization of MERS HCA-outbreaks. Our results highlight heterogeneities in the epidemiological profile of healthcare-associated outbreaks. The limitations of our study stress the urgent need for standardized data collection for high-threat respiratory pathogens, such as MERS-CoV.
SN - 2045-2322
UR - https://www.unboundmedicine.com/medline/citation/31089148/Comparative_Analysis_of_Eleven_Healthcare_Associated_Outbreaks_of_Middle_East_Respiratory_Syndrome_Coronavirus__Mers_Cov__from_2015_to_2017_
DB - PRIME
DP - Unbound Medicine
ER -
