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Serum FGF21 Levels in Obese Korean Children and Adolescents.
J Obes Metab Syndr 2017; 26(3):204-209JO

Abstract

Background

Serum fibroblast growth factor 21 (FGF21) has been suggested to be a possible biomarker for early detection of metabolic syndrome and type 2 diabetes in adults. However, few studies have investigated the correlation between FGF21 levels and metabolic parameters in children. This study sought to evaluate the relationship between FGF21 and metabolic parameters in obese Korean children and adolescents.

Methods

Fasting serum FGF21 and adiponectin levels as well as fasting insulin, glucose, transaminases, and lipid profiles were measured by enzyme-linked immunosorbent assays in 45 lean and 70 obese children aged 7-14 years. Independent t-test and multivariate correlation analysis were used to evaluate the relationship between FGF21 and metabolic parameters.

Results

Serum FGF21 was significantly higher in obese children than in lean children. Serum FGF21 levels were positively correlated with insulin resistance index homeostasis model assessment (HOMA-IR) (r=0.355, P=0.004) and triglycerides (r=0.423, P<0.001) and were negatively correlated with high-density lipoprotein (HDL) cholesterol (r=-0.412, P<0.001). After adjustment for body mass index, triglycerides, HDL cholesterol and adiponectin, FGF21 levels showed a significant correlation with only HOMA-IR on multivariate linear regression analysis.

Conclusion

Serum FGF21 levels were higher in obese children and significantly correlated with HOMA-IR. Therefore, FGF21 could be a biomarker for obesity-induced insulin resistance in children and adolescents as indicated in adults.

Authors+Show Affiliations

Department of Pediatrics, Na-Eun Hospital, Incheon, Korea.Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Korea.Department of Pediatrics, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31089518

Citation

Baek, Joonwoo, et al. "Serum FGF21 Levels in Obese Korean Children and Adolescents." Journal of Obesity & Metabolic Syndrome, vol. 26, no. 3, 2017, pp. 204-209.
Baek J, Nam HK, Rhie YJ, et al. Serum FGF21 Levels in Obese Korean Children and Adolescents. J Obes Metab Syndr. 2017;26(3):204-209.
Baek, J., Nam, H. K., Rhie, Y. J., & Lee, K. H. (2017). Serum FGF21 Levels in Obese Korean Children and Adolescents. Journal of Obesity & Metabolic Syndrome, 26(3), pp. 204-209. doi:10.7570/jomes.2017.26.3.204.
Baek J, et al. Serum FGF21 Levels in Obese Korean Children and Adolescents. J Obes Metab Syndr. 2017;26(3):204-209. PubMed PMID: 31089518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum FGF21 Levels in Obese Korean Children and Adolescents. AU - Baek,Joonwoo, AU - Nam,Hyo-Kyoung, AU - Rhie,Young-Jun, AU - Lee,Kee-Hyoung, Y1 - 2017/09/30/ PY - 2017/05/26/received PY - 2017/06/29/revised PY - 2017/09/06/accepted PY - 2019/5/16/entrez PY - 2017/9/1/pubmed PY - 2017/9/1/medline KW - Child KW - Fibroblast growth factor KW - Insulin resistance KW - Obesity SP - 204 EP - 209 JF - Journal of obesity & metabolic syndrome JO - J Obes Metab Syndr VL - 26 IS - 3 N2 - Background: Serum fibroblast growth factor 21 (FGF21) has been suggested to be a possible biomarker for early detection of metabolic syndrome and type 2 diabetes in adults. However, few studies have investigated the correlation between FGF21 levels and metabolic parameters in children. This study sought to evaluate the relationship between FGF21 and metabolic parameters in obese Korean children and adolescents. Methods: Fasting serum FGF21 and adiponectin levels as well as fasting insulin, glucose, transaminases, and lipid profiles were measured by enzyme-linked immunosorbent assays in 45 lean and 70 obese children aged 7-14 years. Independent t-test and multivariate correlation analysis were used to evaluate the relationship between FGF21 and metabolic parameters. Results: Serum FGF21 was significantly higher in obese children than in lean children. Serum FGF21 levels were positively correlated with insulin resistance index homeostasis model assessment (HOMA-IR) (r=0.355, P=0.004) and triglycerides (r=0.423, P<0.001) and were negatively correlated with high-density lipoprotein (HDL) cholesterol (r=-0.412, P<0.001). After adjustment for body mass index, triglycerides, HDL cholesterol and adiponectin, FGF21 levels showed a significant correlation with only HOMA-IR on multivariate linear regression analysis. Conclusion: Serum FGF21 levels were higher in obese children and significantly correlated with HOMA-IR. Therefore, FGF21 could be a biomarker for obesity-induced insulin resistance in children and adolescents as indicated in adults. SN - 2508-7576 UR - https://www.unboundmedicine.com/medline/citation/31089518/Serum_FGF21_Levels_in_Obese_Korean_Children_and_Adolescents_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31089518/ DB - PRIME DP - Unbound Medicine ER -