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Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis.
Thromb Haemost. 1987 Feb 03; 57(1):67-72.TH

Abstract

The fibrinolytic system was investigated in 120 patients with spontaneous or recurrent deep vein thrombosis (DVT) without any known organic disease able to explain by itself the occurrence of a thrombosis and without any known defect of antithrombin III, Heparin Cofactor II, Protein C, or Protein S. The assays included: Euglobulin fibrinolytic activity (EFA), tissue-type plasminogen activator related antigen (t-PA-Ag) and plasminogen activator inhibitor activity (PA inhibitor), which were measured before and after 10 min of venous occlusion (V.O.). On the basis of the results, the patients could be classified in 3 groups: good responders with an at least two-fold increase of EFA after venous occlusion (n = 76), poor responders with a lesser increase of EFA due to deficient release of t-PA (n = 12), and poor responders with a normal t-PA release but an increased level of PA-Inhibitor (n = 32). The poor responders due to deficient t-PA release (10% of total) had a higher incidence of recurrence of deep vein thrombosis, than the other groups (p less than 0.01). An overall correlation was found between the level of PA-Inhibitor activity and the triglyceride level (r = 0.40, p less than 0.01), suggesting that these elevations may be due to a common cause, at least in some of the patients. It is concluded that a poor fibrinolytic response to venous occlusion occurs in 35 percent of DVT patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3109059

Citation

Juhan-Vague, I, et al. "Deficient t-PA Release and Elevated PA Inhibitor Levels in Patients With Spontaneous or Recurrent Deep Venous Thrombosis." Thrombosis and Haemostasis, vol. 57, no. 1, 1987, pp. 67-72.
Juhan-Vague I, Valadier J, Alessi MC, et al. Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis. Thromb Haemost. 1987;57(1):67-72.
Juhan-Vague, I., Valadier, J., Alessi, M. C., Aillaud, M. F., Ansaldi, J., Philip-Joet, C., Holvoet, P., Serradimigni, A., & Collen, D. (1987). Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis. Thrombosis and Haemostasis, 57(1), 67-72.
Juhan-Vague I, et al. Deficient t-PA Release and Elevated PA Inhibitor Levels in Patients With Spontaneous or Recurrent Deep Venous Thrombosis. Thromb Haemost. 1987 Feb 3;57(1):67-72. PubMed PMID: 3109059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis. AU - Juhan-Vague,I, AU - Valadier,J, AU - Alessi,M C, AU - Aillaud,M F, AU - Ansaldi,J, AU - Philip-Joet,C, AU - Holvoet,P, AU - Serradimigni,A, AU - Collen,D, PY - 1987/2/3/pubmed PY - 1987/2/3/medline PY - 1987/2/3/entrez SP - 67 EP - 72 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 57 IS - 1 N2 - The fibrinolytic system was investigated in 120 patients with spontaneous or recurrent deep vein thrombosis (DVT) without any known organic disease able to explain by itself the occurrence of a thrombosis and without any known defect of antithrombin III, Heparin Cofactor II, Protein C, or Protein S. The assays included: Euglobulin fibrinolytic activity (EFA), tissue-type plasminogen activator related antigen (t-PA-Ag) and plasminogen activator inhibitor activity (PA inhibitor), which were measured before and after 10 min of venous occlusion (V.O.). On the basis of the results, the patients could be classified in 3 groups: good responders with an at least two-fold increase of EFA after venous occlusion (n = 76), poor responders with a lesser increase of EFA due to deficient release of t-PA (n = 12), and poor responders with a normal t-PA release but an increased level of PA-Inhibitor (n = 32). The poor responders due to deficient t-PA release (10% of total) had a higher incidence of recurrence of deep vein thrombosis, than the other groups (p less than 0.01). An overall correlation was found between the level of PA-Inhibitor activity and the triglyceride level (r = 0.40, p less than 0.01), suggesting that these elevations may be due to a common cause, at least in some of the patients. It is concluded that a poor fibrinolytic response to venous occlusion occurs in 35 percent of DVT patients.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/3109059/Deficient_t_PA_release_and_elevated_PA_inhibitor_levels_in_patients_with_spontaneous_or_recurrent_deep_venous_thrombosis_ L2 - https://www.diseaseinfosearch.org/result/7087 DB - PRIME DP - Unbound Medicine ER -