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Machine perfusion versus cold storage in renal preservation of deceased donors with brain death: systematic review and meta-analysis.
Rev Col Bras Cir 2019; 46(2):e2079RC

Abstract

With the increasing use of machine perfusion in kidney transplantation, it has been observed that dynamic ischemia correlates with the improvement of organ preservation. In this context, we performed a systematic review that aimed to evaluate the efficacy of the portable machine perfusion (LifePort Kidney Transporter Machine®), used in Brazil, compared to cold storage, regarding the delayed graft function of deceased donors with brain death. Literature search was carried out in LILACS, MEDLINE via PubMed, Scopus, Clarivate Analytics, Cochrane Library, Embase, and SciELO, as well as in Google Scholar manually. The systematic review consisted only of randomized clinical trials. For meta-analysis, relative risk and odds ratio were evaluated. Eighty-six documents were identified and two papers from European and Brazilian groups were selected at the end, with eligibility criteria for meta-analysis. In these, 374 kidneys were assigned to machine perfusion and 374 kidneys were assigned to cold storage. Delayed graft function was observed in 84 and 110 patients, respectively. In meta-analysis, a risk ratio of 0.7568 (p=0.0151) and an odds ratio of 0.6665 (p=0.0225) were obtained, both with a 95% confidence interval. Machine perfusion reduced the incidence of delayed graft function of deceased donors with brain death.

Authors+Show Affiliations

Universidade Federal do Rio de Janeiro, Programa de Pós-Graduação em Ciências Cirúrgicas, Departamento de Cirurgia, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Departamento de Cirurgia, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Biblioteca, Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro, Instituto de Matemática e Estatística, Departamento de Estatística, Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro, Departamento de Cirurgia, Rio de Janeiro, RJ, Brasil.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

por eng

PubMed ID

31090864

Citation

Leite, Ricardo Ribas de Almeida, et al. "Machine Perfusion Versus Cold Storage in Renal Preservation of Deceased Donors With Brain Death: Systematic Review and Meta-analysis." Revista Do Colegio Brasileiro De Cirurgioes, vol. 46, no. 2, 2019, pp. e2079.
Leite RRA, Schanaider A, da-Fonseca ER, et al. Machine perfusion versus cold storage in renal preservation of deceased donors with brain death: systematic review and meta-analysis. Rev Col Bras Cir. 2019;46(2):e2079.
Leite, R. R. A., Schanaider, A., da-Fonseca, E. R., Xavier, V. L., & de-Miranda, L. C. D. (2019). Machine perfusion versus cold storage in renal preservation of deceased donors with brain death: systematic review and meta-analysis. Revista Do Colegio Brasileiro De Cirurgioes, 46(2), pp. e2079. doi:10.1590/0100-6991e-20192079.
Leite RRA, et al. Machine Perfusion Versus Cold Storage in Renal Preservation of Deceased Donors With Brain Death: Systematic Review and Meta-analysis. Rev Col Bras Cir. 2019 May 9;46(2):e2079. PubMed PMID: 31090864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Machine perfusion versus cold storage in renal preservation of deceased donors with brain death: systematic review and meta-analysis. AU - Leite,Ricardo Ribas de Almeida, AU - Schanaider,Alberto, AU - da-Fonseca,Eliana Rosa, AU - Xavier,Vinicius Layter, AU - de-Miranda,Luiz Carlos Duarte, PY - 2018/12/03/received PY - 2019/02/05/accepted PY - 2019/5/16/entrez PY - 2019/5/16/pubmed PY - 2019/6/22/medline SP - e2079 EP - e2079 JF - Revista do Colegio Brasileiro de Cirurgioes JO - Rev Col Bras Cir VL - 46 IS - 2 N2 - With the increasing use of machine perfusion in kidney transplantation, it has been observed that dynamic ischemia correlates with the improvement of organ preservation. In this context, we performed a systematic review that aimed to evaluate the efficacy of the portable machine perfusion (LifePort Kidney Transporter Machine®), used in Brazil, compared to cold storage, regarding the delayed graft function of deceased donors with brain death. Literature search was carried out in LILACS, MEDLINE via PubMed, Scopus, Clarivate Analytics, Cochrane Library, Embase, and SciELO, as well as in Google Scholar manually. The systematic review consisted only of randomized clinical trials. For meta-analysis, relative risk and odds ratio were evaluated. Eighty-six documents were identified and two papers from European and Brazilian groups were selected at the end, with eligibility criteria for meta-analysis. In these, 374 kidneys were assigned to machine perfusion and 374 kidneys were assigned to cold storage. Delayed graft function was observed in 84 and 110 patients, respectively. In meta-analysis, a risk ratio of 0.7568 (p=0.0151) and an odds ratio of 0.6665 (p=0.0225) were obtained, both with a 95% confidence interval. Machine perfusion reduced the incidence of delayed graft function of deceased donors with brain death. SN - 1809-4546 UR - https://www.unboundmedicine.com/medline/citation/31090864/Machine_perfusion_versus_cold_storage_in_renal_preservation_of_deceased_donors_with_brain_death:_systematic_review_and_meta-analysis L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912019000200300&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -