Tags

Type your tag names separated by a space and hit enter

Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway.
IUBMB Life. 2019 07; 71(7):1041-1047.IL

Abstract

For the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory process. Luteolin (Lut) is a plant flavonoid, a pharmacologically active component normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom; it exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Lut on bisphenol A (BPA)-induced nephron toxicity in rats. Orally administering Lut (100 and 200 mg/kg) diminished BPA-induced anomalies in the kidney, blood urea nitrogen, creatinine, and serum uric acid levels. Lut therapy reduced the BPA-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. This was coupled with significant improvement in kidney histopathologic features. Lut enhanced the nuclear factor-like 2 (Nrf2) and heme oxygenase 1 (HO-1) expression, which showed protection against OS induced by BPA. The current outcomes of the study showed that Lut has a strong reactive oxygen species scavenging property and potentially decreases the lipid peroxidation as well as inhibits DNA damage in renal toxicity induced by BPA. In conclusion, the potential antioxidant effect of Lut may be because of its modulatory effect on the Nrf2/antioxidant response element (ARE)/HO-1 pathway, which means it protects the kidney from BPA-induced oxidative injury. © 2019 IUBMB Life, 2019.

Authors+Show Affiliations

AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31091348

Citation

Alekhya Sita, Gadamsetty Jaya, et al. "Protective Role of Luteolin Against Bisphenol A-induced Renal Toxicity Through Suppressing Oxidative Stress, Inflammation, and Upregulating Nrf2/ARE/ HO-1 Pathway." IUBMB Life, vol. 71, no. 7, 2019, pp. 1041-1047.
Alekhya Sita GJ, Gowthami M, Srikanth G, et al. Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway. IUBMB Life. 2019;71(7):1041-1047.
Alekhya Sita, G. J., Gowthami, M., Srikanth, G., Krishna, M. M., Rama Sireesha, K., Sajjarao, M., Nagarjuna, K., Nagarjuna, M., Chinnaboina, G. K., Mishra, A., & SreeHarsha, N. (2019). Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway. IUBMB Life, 71(7), 1041-1047. https://doi.org/10.1002/iub.2066
Alekhya Sita GJ, et al. Protective Role of Luteolin Against Bisphenol A-induced Renal Toxicity Through Suppressing Oxidative Stress, Inflammation, and Upregulating Nrf2/ARE/ HO-1 Pathway. IUBMB Life. 2019;71(7):1041-1047. PubMed PMID: 31091348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway. AU - Alekhya Sita,Gadamsetty Jaya, AU - Gowthami,Motati, AU - Srikanth,Gadiparthi, AU - Krishna,M Murali, AU - Rama Sireesha,Kokkiligadda, AU - Sajjarao,Mounika, AU - Nagarjuna,Kandru, AU - Nagarjuna,Mukkamulla, AU - Chinnaboina,Gopala Krishna, AU - Mishra,Anurag, AU - SreeHarsha,Nagaraja, Y1 - 2019/05/15/ PY - 2019/03/26/received PY - 2019/04/24/accepted PY - 2019/5/16/pubmed PY - 2020/4/17/medline PY - 2019/5/16/entrez KW - anti-inflammatory KW - antioxidant KW - bisphenol A KW - luteolin KW - nephrotoxicity SP - 1041 EP - 1047 JF - IUBMB life JO - IUBMB Life VL - 71 IS - 7 N2 - For the development of renal diseases, oxidative stress (OS) is reasoned to be one of the risk factors. For the treatment or prevention of the renal disease, the use of antioxidants could be a hopeful therapeutic mediation as they retard or block the oxidative reaction along with the inflammatory process. Luteolin (Lut) is a plant flavonoid, a pharmacologically active component normally found in glycosylated forms in basic perilla leaf, green pepper, celery, seed, honeysuckle bloom, and chamomile blossom; it exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Lut on bisphenol A (BPA)-induced nephron toxicity in rats. Orally administering Lut (100 and 200 mg/kg) diminished BPA-induced anomalies in the kidney, blood urea nitrogen, creatinine, and serum uric acid levels. Lut therapy reduced the BPA-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. This was coupled with significant improvement in kidney histopathologic features. Lut enhanced the nuclear factor-like 2 (Nrf2) and heme oxygenase 1 (HO-1) expression, which showed protection against OS induced by BPA. The current outcomes of the study showed that Lut has a strong reactive oxygen species scavenging property and potentially decreases the lipid peroxidation as well as inhibits DNA damage in renal toxicity induced by BPA. In conclusion, the potential antioxidant effect of Lut may be because of its modulatory effect on the Nrf2/antioxidant response element (ARE)/HO-1 pathway, which means it protects the kidney from BPA-induced oxidative injury. © 2019 IUBMB Life, 2019. SN - 1521-6551 UR - https://www.unboundmedicine.com/medline/citation/31091348/Protective_role_of_luteolin_against_bisphenol_A_induced_renal_toxicity_through_suppressing_oxidative_stress_inflammation_and_upregulating_Nrf2/ARE/_HO_1_pathway_ L2 - https://doi.org/10.1002/iub.2066 DB - PRIME DP - Unbound Medicine ER -