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Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson's disease (PD): a meta-analysis for the diagnosis of RLS in PD patients.
Int J Neurosci. 2019 Oct; 129(10):995-1003.IJ

Abstract

Objective:

Restless legs syndrome (RLS) is one of the most common non-motor symptoms of Parkinson's disease (PD), but its pathogenesis in a PD background is unclear. Abnormal iron metabolism may be involved, in which case it may be a marker of RLS risk. Here, the literature was systematically searched and meta-analyzed to compare iron metabolism markers between PD patients with or without RLS. Method: The databases PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, Web of Science, and SinoMed were searched for case-control and observational studies examining RLS-related changes in iron metabolism in PD, in terms of serum iron, serum ferritin and hemoglobin. Eligible studies were meta-analyzed using Stata 12.0.

Results:

Meta-analysis of 11 case-control studies showed that serum ferritin concentration was lower in PD patients with RLS than in those without RLS. (95%CI -0.32 to -0.03, p = 0.018). In contrast, levels of serum iron or hemoglobin did not differ significantly between PD patients with or without RLS.

Conclusion:

This meta-analysis may provide the first reliable pooled estimate of the correlation between abnormal iron metabolism and RLS in PD. The available evidence indicates that levels of ferritin, but not of serum iron or hemoglobin, correlate significantly with RLS in PD, with lower ferritin levels correlating to greater prevalence of RLS.

Authors+Show Affiliations

Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Neurology, West China Hospital, SCU , Chengdu , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University , Kunming , People's Republic of China.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

31092087

Citation

Li, Kelu, et al. "Decreased Serum Ferritin May Be Associated With Increased Restless Legs Syndrome in Parkinson's Disease (PD): a Meta-analysis for the Diagnosis of RLS in PD Patients." The International Journal of Neuroscience, vol. 129, no. 10, 2019, pp. 995-1003.
Li K, Liu B, Wang F, et al. Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson's disease (PD): a meta-analysis for the diagnosis of RLS in PD patients. Int J Neurosci. 2019;129(10):995-1003.
Li, K., Liu, B., Wang, F., Bao, J., Wu, C., Huang, X., Hu, F., Xu, Z., Ren, H., & Yang, X. (2019). Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson's disease (PD): a meta-analysis for the diagnosis of RLS in PD patients. The International Journal of Neuroscience, 129(10), 995-1003. https://doi.org/10.1080/00207454.2019.1608200
Li K, et al. Decreased Serum Ferritin May Be Associated With Increased Restless Legs Syndrome in Parkinson's Disease (PD): a Meta-analysis for the Diagnosis of RLS in PD Patients. Int J Neurosci. 2019;129(10):995-1003. PubMed PMID: 31092087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson's disease (PD): a meta-analysis for the diagnosis of RLS in PD patients. AU - Li,Kelu, AU - Liu,Bin, AU - Wang,Fang, AU - Bao,Jianjian, AU - Wu,Chongmin, AU - Huang,Xiaodong, AU - Hu,Fayun, AU - Xu,Zhong, AU - Ren,Hui, AU - Yang,Xinglong, Y1 - 2019/06/17/ PY - 2019/5/17/pubmed PY - 2020/1/31/medline PY - 2019/5/17/entrez KW - Parkinson’s disease KW - Restless legs syndrome KW - ferritin KW - meta-analysis SP - 995 EP - 1003 JF - The International journal of neuroscience JO - Int J Neurosci VL - 129 IS - 10 N2 - Objective: Restless legs syndrome (RLS) is one of the most common non-motor symptoms of Parkinson's disease (PD), but its pathogenesis in a PD background is unclear. Abnormal iron metabolism may be involved, in which case it may be a marker of RLS risk. Here, the literature was systematically searched and meta-analyzed to compare iron metabolism markers between PD patients with or without RLS. Method: The databases PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, Web of Science, and SinoMed were searched for case-control and observational studies examining RLS-related changes in iron metabolism in PD, in terms of serum iron, serum ferritin and hemoglobin. Eligible studies were meta-analyzed using Stata 12.0. Results: Meta-analysis of 11 case-control studies showed that serum ferritin concentration was lower in PD patients with RLS than in those without RLS. (95%CI -0.32 to -0.03, p = 0.018). In contrast, levels of serum iron or hemoglobin did not differ significantly between PD patients with or without RLS. Conclusion: This meta-analysis may provide the first reliable pooled estimate of the correlation between abnormal iron metabolism and RLS in PD. The available evidence indicates that levels of ferritin, but not of serum iron or hemoglobin, correlate significantly with RLS in PD, with lower ferritin levels correlating to greater prevalence of RLS. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/31092087/Decreased_serum_ferritin_may_be_associated_with_increased_restless_legs_syndrome_in_Parkinson's_disease__PD_:_a_meta_analysis_for_the_diagnosis_of_RLS_in_PD_patients_ L2 - https://www.tandfonline.com/doi/full/10.1080/00207454.2019.1608200 DB - PRIME DP - Unbound Medicine ER -