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The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Curr Pharm Des. 2019; 25(12):1372-1384.CP

Abstract

BACKGROUND

This systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to determine the effect of quercetin administration on blood pressures and endothelial function among patients with metabolic syndrome (MetS) and related disorders.

METHODS

We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until December 2018. Q-test and I2 statistics were applied to assess heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.

RESULTS

Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements. However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD: -3.14; 95% CI: -8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD: -24.49; 95% CI: -53.74, 4.77) and intercellular adhesion molecule 1 (ICAM-1) (WMD: -5.78; 95% CI: -12.93, 1.38).

CONCLUSION

In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders.

Authors+Show Affiliations

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.Halal Research Center of IRI, FDA, Tehran, Iran.Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada.Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

31092175

Citation

Tamtaji, Omid R., et al. "The Effects of Quercetin Supplementation On Blood Pressures and Endothelial Function Among Patients With Metabolic Syndrome and Related Disorders: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Current Pharmaceutical Design, vol. 25, no. 12, 2019, pp. 1372-1384.
Tamtaji OR, Milajerdi A, Dadgostar E, et al. The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Curr Pharm Des. 2019;25(12):1372-1384.
Tamtaji, O. R., Milajerdi, A., Dadgostar, E., Kolahdooz, F., Chamani, M., Amirani, E., Mirzaei, H., & Asemi, Z. (2019). The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Current Pharmaceutical Design, 25(12), 1372-1384. https://doi.org/10.2174/1381612825666190513095352
Tamtaji OR, et al. The Effects of Quercetin Supplementation On Blood Pressures and Endothelial Function Among Patients With Metabolic Syndrome and Related Disorders: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Curr Pharm Des. 2019;25(12):1372-1384. PubMed PMID: 31092175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials. AU - Tamtaji,Omid R, AU - Milajerdi,Alireza, AU - Dadgostar,Ehsan, AU - Kolahdooz,Fariba, AU - Chamani,Maryam, AU - Amirani,Elaheh, AU - Mirzaei,Hamed, AU - Asemi,Zatollah, PY - 2019/03/27/received PY - 2019/05/01/accepted PY - 2019/5/17/pubmed PY - 2020/2/28/medline PY - 2019/5/17/entrez KW - Quercetin KW - blood pressures KW - endothelial function KW - meta-analysis KW - metabolic syndrome KW - randomized controlled trials. SP - 1372 EP - 1384 JF - Current pharmaceutical design JO - Curr. Pharm. Des. VL - 25 IS - 12 N2 - BACKGROUND: This systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to determine the effect of quercetin administration on blood pressures and endothelial function among patients with metabolic syndrome (MetS) and related disorders. METHODS: We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until December 2018. Q-test and I2 statistics were applied to assess heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. RESULTS: Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements. However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD: -3.14; 95% CI: -8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD: -24.49; 95% CI: -53.74, 4.77) and intercellular adhesion molecule 1 (ICAM-1) (WMD: -5.78; 95% CI: -12.93, 1.38). CONCLUSION: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/31092175/The_Effects_of_Quercetin_Supplementation_on_Blood_Pressures_and_Endothelial_Function_Among_Patients_with_Metabolic_Syndrome_and_Related_Disorders:_A_Systematic_Review_and_Meta_analysis_of_Randomized_Controlled_Trials_ L2 - http://www.eurekaselect.com/172091/article DB - PRIME DP - Unbound Medicine ER -