Tags

Type your tag names separated by a space and hit enter

Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model.
Indian J Clin Biochem. 2019 Apr; 34(2):155-163.IJ

Abstract

Abstract

The medicinal plant, Terminalia bellirica (Gaertn.) Roxb. is widely used in the traditional Indian system of medicine like Ayurveda for centuries in the treatment of various ailments owing to it's rejuvenating as well as health promoting effects. The present study evaluates protective role of aqueous acetone extract of T. bellirica fruits (AATB) against CCl4 induced liver toxicity in animal model. The liver damage was assessed by liver function markers including ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin and albumin-globulin ratio. The levels of MDA, ROS, and NO along with the tissue antioxidants were evaluated to assess hepatic oxidative stress and level of lipid peroxidation. Treatment with AATB prior to the exposure of CCl4 significantly reduced the damage when compared to the control rats. The outcome of the present study advocates the traditional use of the plant as ethnic food and health tonic.

Authors+Show Affiliations

School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala India.School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31092988

Citation

Jayesh, Kuriakose, et al. "Protective Role of Terminalia Bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model." Indian Journal of Clinical Biochemistry : IJCB, vol. 34, no. 2, 2019, pp. 155-163.
Jayesh K, Helen LR, Vysakh A, et al. Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Indian J Clin Biochem. 2019;34(2):155-163.
Jayesh, K., Helen, L. R., Vysakh, A., Binil, E., & Latha, M. S. (2019). Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Indian Journal of Clinical Biochemistry : IJCB, 34(2), 155-163. https://doi.org/10.1007/s12291-017-0732-8
Jayesh K, et al. Protective Role of Terminalia Bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Indian J Clin Biochem. 2019;34(2):155-163. PubMed PMID: 31092988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. AU - Jayesh,Kuriakose, AU - Helen,Lal Raisa, AU - Vysakh,A, AU - Binil,Eldhose, AU - Latha,M S, Y1 - 2018/02/07/ PY - 2017/08/12/received PY - 2017/12/22/accepted PY - 2020/04/01/pmc-release PY - 2019/5/17/entrez PY - 2019/5/17/pubmed PY - 2019/5/17/medline KW - Carbon tetrachloride KW - Liver injury KW - Oxidative stress KW - Terminalia bellirica fruit SP - 155 EP - 163 JF - Indian journal of clinical biochemistry : IJCB JO - Indian J Clin Biochem VL - 34 IS - 2 N2 - Abstract: The medicinal plant, Terminalia bellirica (Gaertn.) Roxb. is widely used in the traditional Indian system of medicine like Ayurveda for centuries in the treatment of various ailments owing to it's rejuvenating as well as health promoting effects. The present study evaluates protective role of aqueous acetone extract of T. bellirica fruits (AATB) against CCl4 induced liver toxicity in animal model. The liver damage was assessed by liver function markers including ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin and albumin-globulin ratio. The levels of MDA, ROS, and NO along with the tissue antioxidants were evaluated to assess hepatic oxidative stress and level of lipid peroxidation. Treatment with AATB prior to the exposure of CCl4 significantly reduced the damage when compared to the control rats. The outcome of the present study advocates the traditional use of the plant as ethnic food and health tonic. SN - 0970-1915 UR - https://www.unboundmedicine.com/medline/citation/31092988/Protective_Role_of_Terminalia_bellirica_(Gaertn.)_Roxb_Fruits_Against_CCl4_Induced_Oxidative_Stress_and_Liver_Injury_in_Rodent_Model L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31092988/ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.