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Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model.
Hum Reprod Open 2019; 34(2):155-163HR

Abstract

Abstract

The medicinal plant, Terminalia bellirica (Gaertn.) Roxb. is widely used in the traditional Indian system of medicine like Ayurveda for centuries in the treatment of various ailments owing to it's rejuvenating as well as health promoting effects. The present study evaluates protective role of aqueous acetone extract of T. bellirica fruits (AATB) against CCl4 induced liver toxicity in animal model. The liver damage was assessed by liver function markers including ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin and albumin-globulin ratio. The levels of MDA, ROS, and NO along with the tissue antioxidants were evaluated to assess hepatic oxidative stress and level of lipid peroxidation. Treatment with AATB prior to the exposure of CCl4 significantly reduced the damage when compared to the control rats. The outcome of the present study advocates the traditional use of the plant as ethnic food and health tonic.

Authors+Show Affiliations

ICCBBA, Redlands, CA, USA.IVFCryo, LLC, Los Angeles, CA, USA.Department of Ob/GYN, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.ICCBBA, Redlands, CA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31092988

Citation

Ashford, P, et al. "Protective Role of Terminalia Bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model." Indian Journal of Clinical Biochemistry : IJCB, vol. 34, no. 2, 2019, pp. 155-163.
Ashford P, Rydman K, Sparks A, et al. Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Indian J Clin Biochem. 2019;34(2):155-163.
Ashford, P., Rydman, K., Sparks, A., Tilleman, K., & Freire, M. (2019). Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Indian Journal of Clinical Biochemistry : IJCB, 34(2), pp. 155-163. doi:10.1007/s12291-017-0732-8.
Ashford P, et al. Protective Role of Terminalia Bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. Indian J Clin Biochem. 2019;34(2):155-163. PubMed PMID: 31092988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Role of Terminalia bellirica (Gaertn.) Roxb Fruits Against CCl4 Induced Oxidative Stress and Liver Injury in Rodent Model. AU - Ashford,P, AU - Rydman,K, AU - Sparks,A, AU - Tilleman,K, AU - Freire,M, Y1 - 2019/03/29/ PY - 2018/12/12/received PY - 2019/01/18/revised PY - 2019/02/11/accepted PY - 2019/4/6/entrez PY - 2019/4/6/pubmed PY - 2019/4/6/medline KW - ART KW - ISBT 128 KW - classification KW - coding KW - products KW - standardization KW - terminology KW - tissue banking SP - 155 EP - 163 JF - Indian journal of clinical biochemistry : IJCB JO - Indian J Clin Biochem VL - 34 IS - 2 N2 - Abstract: The medicinal plant, Terminalia bellirica (Gaertn.) Roxb. is widely used in the traditional Indian system of medicine like Ayurveda for centuries in the treatment of various ailments owing to it's rejuvenating as well as health promoting effects. The present study evaluates protective role of aqueous acetone extract of T. bellirica fruits (AATB) against CCl4 induced liver toxicity in animal model. The liver damage was assessed by liver function markers including ALT, AST, ALP, GGT, LDH, total bilirubin, total protein, albumin, globulin and albumin-globulin ratio. The levels of MDA, ROS, and NO along with the tissue antioxidants were evaluated to assess hepatic oxidative stress and level of lipid peroxidation. Treatment with AATB prior to the exposure of CCl4 significantly reduced the damage when compared to the control rats. The outcome of the present study advocates the traditional use of the plant as ethnic food and health tonic. SN - 0970-1915 UR - https://www.unboundmedicine.com/medline/citation/31092988/Protective_Role_of_Terminalia_bellirica_(Gaertn.)_Roxb_Fruits_Against_CCl4_Induced_Oxidative_Stress_and_Liver_Injury_in_Rodent_Model DB - PRIME DP - Unbound Medicine ER -