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Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models.
Biomed J Sci Tech Res 2019; 14(5)BJ

Abstract

Ischemia/reperfusion injury (IRI) is inherent to all transplanted organs and is adversely associated with early renal graft function and graft longevity. Despite the progress in immunosuppressive regimens and perioperative care, no FDA-approved treatment for kidney transplant IRI is available to date. In recent years, by utilizing the modified and clinically-relevant mouse models of kidney transplantation (KTx) in which extended IRI is induced by the prolonged warm or cold ischemic time, studies have identified several potential therapeutic approaches for KTx IRI, including the hormone supplement, promoting tubular repair and regeneration, and targeting complement system, inflammation, and necroptosis. This review describes some of the lessons learned from mouse models of KTx with regard to factors that influence the severity of transplant IRI and the potential therapeutic targets.

Authors+Show Affiliations

Comprehensive Transplant Center, USA.Comprehensive Transplant Center, USA. Department of Surgery, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31093605

Citation

Qiu, Longhui, and Zheng Jenny Zhang. "Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models." Biomedical Journal of Scientific & Technical Research, vol. 14, no. 5, 2019.
Qiu L, Zhang ZJ. Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models. Biomed J Sci Tech Res. 2019;14(5).
Qiu, L., & Zhang, Z. J. (2019). Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models. Biomedical Journal of Scientific & Technical Research, 14(5).
Qiu L, Zhang ZJ. Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models. Biomed J Sci Tech Res. 2019;14(5) PubMed PMID: 31093605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models. AU - Qiu,Longhui, AU - Zhang,Zheng Jenny, Y1 - 2019/02/20/ PY - 2019/5/17/entrez PY - 2019/5/17/pubmed PY - 2019/5/17/medline KW - Cold Ischemic Time KW - Complement KW - Ischemia Reperfusion Injury KW - Kidney KW - Mouse Models KW - Regeneration KW - Therapies KW - Transplantation JF - Biomedical journal of scientific & technical research JO - Biomed J Sci Tech Res VL - 14 IS - 5 N2 - Ischemia/reperfusion injury (IRI) is inherent to all transplanted organs and is adversely associated with early renal graft function and graft longevity. Despite the progress in immunosuppressive regimens and perioperative care, no FDA-approved treatment for kidney transplant IRI is available to date. In recent years, by utilizing the modified and clinically-relevant mouse models of kidney transplantation (KTx) in which extended IRI is induced by the prolonged warm or cold ischemic time, studies have identified several potential therapeutic approaches for KTx IRI, including the hormone supplement, promoting tubular repair and regeneration, and targeting complement system, inflammation, and necroptosis. This review describes some of the lessons learned from mouse models of KTx with regard to factors that influence the severity of transplant IRI and the potential therapeutic targets. SN - 2574-1241 UR - https://www.unboundmedicine.com/medline/citation/31093605/Therapeutic_Strategies_of_Kidney_Transplant_Ischemia_Reperfusion_Injury:_Insight_From_Mouse_Models L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31093605/ DB - PRIME DP - Unbound Medicine ER -