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Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor.
ACS Appl Mater Interfaces 2019; 11(23):20734-20742AA

Abstract

Phenylketonuria (PKU) is a common disease in congenital disorder of amino acid metabolism, which can lead to intellectual disability, seizures, behavioral problems, and mental disorders. We report herein a facile method to screen for PKU by the measurements of its metabolites (markers). In this work, a disposable electrochemical microsensor modified with a ZIF (zeolitic imidazolate framework)-based nanocomposite is constructed, in which ZIF-67 crystals are encapsulated with PtPd alloy nanoparticles (NPs) forming the nanocomposite (PtPd@ZIF-67). According to electrochemical measurements, the PtPd@ZIF-67-modified microsensor shows good responses and selectivity to phenylpyruvic acid and phenylacetic acid, while almost no response toward other amino acid analogues is observed. Here, a new sensing mechanism based on the acylation reaction between the imidazole linker in ZIF-67 and carboxyl in PKU markers has been proposed and verified through the Fourier-transform infrared spectroscopy study. Moreover, the encapsulated PtPd NPs elevate the electron transfer capability of the PtPd@ZIF-67-modified microsensor and further improve the electrochemical sensing performance. Finally, we demonstrate that the developed PtPd@ZIF-67-modified microsensor has the possibility to sensing of PKU markers with high response and good specificity and may be extended to exploit the point-of-care rapid PKU screening.

Authors+Show Affiliations

Materials Genome Institute , Shanghai University , Shanghai 200444 , China.Materials Genome Institute , Shanghai University , Shanghai 200444 , China.Materials Genome Institute , Shanghai University , Shanghai 200444 , China.Materials Genome Institute , Shanghai University , Shanghai 200444 , China.State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology , Chinese Academy of Sciences , Shanghai 200050 , China.State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology , Chinese Academy of Sciences , Shanghai 200050 , China.Department of Chemical Engineering , Case Western Reserve University , Cleveland , Ohio 44106 , United States.Materials Genome Institute , Shanghai University , Shanghai 200444 , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31094505

Citation

Xu, Xinyue, et al. "Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor." ACS Applied Materials & Interfaces, vol. 11, no. 23, 2019, pp. 20734-20742.
Xu X, Ji D, Zhang Y, et al. Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Appl Mater Interfaces. 2019;11(23):20734-20742.
Xu, X., Ji, D., Zhang, Y., Gao, X., Xu, P., Li, X., ... Wen, W. (2019). Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Applied Materials & Interfaces, 11(23), pp. 20734-20742. doi:10.1021/acsami.9b05431.
Xu X, et al. Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. ACS Appl Mater Interfaces. 2019 Jun 12;11(23):20734-20742. PubMed PMID: 31094505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Phenylketonuria Markers Using a ZIF-67 Encapsulated PtPd Alloy Nanoparticle (PtPd@ZIF-67)-Based Disposable Electrochemical Microsensor. AU - Xu,Xinyue, AU - Ji,Dongqing, AU - Zhang,Yuan, AU - Gao,Xinghua, AU - Xu,Pengcheng, AU - Li,Xinxin, AU - Liu,Chung-Chiun, AU - Wen,Weijia, Y1 - 2019/05/28/ PY - 2019/5/17/pubmed PY - 2019/5/17/medline PY - 2019/5/17/entrez KW - PKU markers KW - ZIF-67 KW - disposable microsensor KW - electrochemical sensing KW - encapsulation KW - metal nanoparticles SP - 20734 EP - 20742 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 11 IS - 23 N2 - Phenylketonuria (PKU) is a common disease in congenital disorder of amino acid metabolism, which can lead to intellectual disability, seizures, behavioral problems, and mental disorders. We report herein a facile method to screen for PKU by the measurements of its metabolites (markers). In this work, a disposable electrochemical microsensor modified with a ZIF (zeolitic imidazolate framework)-based nanocomposite is constructed, in which ZIF-67 crystals are encapsulated with PtPd alloy nanoparticles (NPs) forming the nanocomposite (PtPd@ZIF-67). According to electrochemical measurements, the PtPd@ZIF-67-modified microsensor shows good responses and selectivity to phenylpyruvic acid and phenylacetic acid, while almost no response toward other amino acid analogues is observed. Here, a new sensing mechanism based on the acylation reaction between the imidazole linker in ZIF-67 and carboxyl in PKU markers has been proposed and verified through the Fourier-transform infrared spectroscopy study. Moreover, the encapsulated PtPd NPs elevate the electron transfer capability of the PtPd@ZIF-67-modified microsensor and further improve the electrochemical sensing performance. Finally, we demonstrate that the developed PtPd@ZIF-67-modified microsensor has the possibility to sensing of PKU markers with high response and good specificity and may be extended to exploit the point-of-care rapid PKU screening. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/31094505/Detection_of_Phenylketonuria_Markers_Using_a_ZIF-67_Encapsulated_PtPd_Alloy_Nanoparticle_(PtPd@ZIF-67)-Based_Disposable_Electrochemical_Microsensor L2 - https://dx.doi.org/10.1021/acsami.9b05431 DB - PRIME DP - Unbound Medicine ER -