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The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies.
Medicine (Baltimore). 2019 May; 98(20):e15448.M

Abstract

BACKGROUND

The single nucleotide polymorphism (SNP) rs2476601 of the protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) gene has been presented to implicate in the pathogenesis of alopecia areata (AA) in a few association investigations with limited sample size and inconsistent conclusions.

METHODS

The aim of the current meta-analysis was to assess and synthesize the presently available data on the connection between rs2476601 and AA vulnerability. Six electronic databases, including EMBASE, PubMed, Web of Science, the Cochrane Library, Wanfang data, and the China National Knowledge Infrastructure database (CNKI), were systematically retrieved for relevant observational studies published previous to November 2018. Total odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were analyzed to evaluate the correlation between PTPN22 polymorphism and AA. Risk of bias was estimated according to the Newcastle-Ottawa Scale (NOS). Sensitivity analyses were carried out using the RevMan 5.3 software.

RESULTS

In general, 5 case-control studies including 1129 AA patients and 1702 healthy control individuals were obtained for this meta-analysis. The pooled results suggested that rs2476601 SNP was significantly associated with AA susceptibility under allelic model (C vs T, OR = 0.77, 95% CI, 0.64-0.92, P = .003) and recessive model (CC vs CT + TT, OR = 0.73, 95% CI, 0.60-0.88, P = .001).

CONCLUSION

On the basis of the results of the current research, the rs2476601 polymorphism of PTPN22 gene is significantly correlated with AA susceptibility. The C-allele and CC-genotype carriers at this locus have a lower risk of AA.

Authors+Show Affiliations

Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang. Xinjiang Medical University, Urumqi, China.Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang. Xinjiang Medical University, Urumqi, China.Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang.Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang. Xinjiang Medical University, Urumqi, China.Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang. Xinjiang Medical University, Urumqi, China.Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang. Xinjiang Medical University, Urumqi, China.Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

31096440

Citation

Lei, Zi-Xian, et al. "The Association Between Rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata: a Meta-analysis of Case-control Studies." Medicine, vol. 98, no. 20, 2019, pp. e15448.
Lei ZX, Chen WJ, Liang JQ, et al. The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies. Medicine (Baltimore). 2019;98(20):e15448.
Lei, Z. X., Chen, W. J., Liang, J. Q., Wang, Y. J., Jin, L., Xu, C., & Kang, X. J. (2019). The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies. Medicine, 98(20), e15448. https://doi.org/10.1097/MD.0000000000015448
Lei ZX, et al. The Association Between Rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata: a Meta-analysis of Case-control Studies. Medicine (Baltimore). 2019;98(20):e15448. PubMed PMID: 31096440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata: A meta-analysis of case-control studies. AU - Lei,Zi-Xian, AU - Chen,Wen-Jing, AU - Liang,Jun-Qin, AU - Wang,Yan-Jun, AU - Jin,Lan, AU - Xu,Chen, AU - Kang,Xiao-Jing, PY - 2019/5/18/entrez PY - 2019/5/18/pubmed PY - 2019/5/29/medline SP - e15448 EP - e15448 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 20 N2 - BACKGROUND: The single nucleotide polymorphism (SNP) rs2476601 of the protein tyrosine phosphatase, nonreceptor type 22 (PTPN22) gene has been presented to implicate in the pathogenesis of alopecia areata (AA) in a few association investigations with limited sample size and inconsistent conclusions. METHODS: The aim of the current meta-analysis was to assess and synthesize the presently available data on the connection between rs2476601 and AA vulnerability. Six electronic databases, including EMBASE, PubMed, Web of Science, the Cochrane Library, Wanfang data, and the China National Knowledge Infrastructure database (CNKI), were systematically retrieved for relevant observational studies published previous to November 2018. Total odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were analyzed to evaluate the correlation between PTPN22 polymorphism and AA. Risk of bias was estimated according to the Newcastle-Ottawa Scale (NOS). Sensitivity analyses were carried out using the RevMan 5.3 software. RESULTS: In general, 5 case-control studies including 1129 AA patients and 1702 healthy control individuals were obtained for this meta-analysis. The pooled results suggested that rs2476601 SNP was significantly associated with AA susceptibility under allelic model (C vs T, OR = 0.77, 95% CI, 0.64-0.92, P = .003) and recessive model (CC vs CT + TT, OR = 0.73, 95% CI, 0.60-0.88, P = .001). CONCLUSION: On the basis of the results of the current research, the rs2476601 polymorphism of PTPN22 gene is significantly correlated with AA susceptibility. The C-allele and CC-genotype carriers at this locus have a lower risk of AA. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31096440/The_association_between_rs2476601_polymorphism_in_PTPN22_gene_and_risk_of_alopecia_areata:_A_meta_analysis_of_case_control_studies_ L2 - http://dx.doi.org/10.1097/MD.0000000000015448 DB - PRIME DP - Unbound Medicine ER -