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Efficient synthesis of novel pyrazole-linked 1,2,4-triazolidine-3-thiones using bismuth on zirconium oxide as a recyclable catalyst in aqueous medium.
Mol Divers. 2020 May; 24(2):345-354.MD

Abstract

The Bi2O3 loading on ZrO2 as heterogeneous catalyst was established as an extremely efficient catalyst for the synthesis of a series of novel 5-(1-(2,4-dinitrophenyl)-3-substituted-phenyl-1H-pyrazol-4-yl)-1,2,4-triazolidine-3-thione derivatives (3a-o) with high yields (90-96%) by reaction of 1-(2,4-dinitrophenyl)-3-substituted-phenyl-1H-pyrazole-4-carbaldehydes and thiosemicarbazide using water as a greener solvent at 80 °C within 30-45 min. Materials with different percentages of Bi2O3 on ZrO2 were prepared by simple wet impregnation method. The synthesized material has been characterized by various techniques (XRD, TEM, SEM, BET). 2.5% Bi2O3/ZrO2 proved superior catalyst. The Bi2O3/ZrO2 catalyst is easily recoverable and reused up to sixth run with no loss of activity. Excellent yields, short reaction time, avoidance of hazardous solvents, and no need for chromatographic purifications are the proven advantages.

Authors+Show Affiliations

School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa.School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa.School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa.School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa.School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa.School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban, 4000, South Africa. jonnalagaddas@ukzn.ac.za.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31098860

Citation

Kerru, Nagaraju, et al. "Efficient Synthesis of Novel Pyrazole-linked 1,2,4-triazolidine-3-thiones Using Bismuth On Zirconium Oxide as a Recyclable Catalyst in Aqueous Medium." Molecular Diversity, vol. 24, no. 2, 2020, pp. 345-354.
Kerru N, Bhaskaruni SVHS, Gummidi L, et al. Efficient synthesis of novel pyrazole-linked 1,2,4-triazolidine-3-thiones using bismuth on zirconium oxide as a recyclable catalyst in aqueous medium. Mol Divers. 2020;24(2):345-354.
Kerru, N., Bhaskaruni, S. V. H. S., Gummidi, L., Maddila, S. N., Singh, P., & Jonnalagadda, S. B. (2020). Efficient synthesis of novel pyrazole-linked 1,2,4-triazolidine-3-thiones using bismuth on zirconium oxide as a recyclable catalyst in aqueous medium. Molecular Diversity, 24(2), 345-354. https://doi.org/10.1007/s11030-019-09957-0
Kerru N, et al. Efficient Synthesis of Novel Pyrazole-linked 1,2,4-triazolidine-3-thiones Using Bismuth On Zirconium Oxide as a Recyclable Catalyst in Aqueous Medium. Mol Divers. 2020;24(2):345-354. PubMed PMID: 31098860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficient synthesis of novel pyrazole-linked 1,2,4-triazolidine-3-thiones using bismuth on zirconium oxide as a recyclable catalyst in aqueous medium. AU - Kerru,Nagaraju, AU - Bhaskaruni,Sandeep V H S, AU - Gummidi,Lalitha, AU - Maddila,Surya Narayana, AU - Singh,Parvesh, AU - Jonnalagadda,Sreekantha B, Y1 - 2019/05/16/ PY - 2019/02/20/received PY - 2019/05/08/accepted PY - 2019/5/18/pubmed PY - 2019/5/18/medline PY - 2019/5/18/entrez KW - 1,2,4-Triazolidine-3-thione KW - Bi2O3/ZrO2 KW - Heterogeneous catalysis KW - Mixed oxides KW - Pyrazole SP - 345 EP - 354 JF - Molecular diversity JO - Mol. Divers. VL - 24 IS - 2 N2 - The Bi2O3 loading on ZrO2 as heterogeneous catalyst was established as an extremely efficient catalyst for the synthesis of a series of novel 5-(1-(2,4-dinitrophenyl)-3-substituted-phenyl-1H-pyrazol-4-yl)-1,2,4-triazolidine-3-thione derivatives (3a-o) with high yields (90-96%) by reaction of 1-(2,4-dinitrophenyl)-3-substituted-phenyl-1H-pyrazole-4-carbaldehydes and thiosemicarbazide using water as a greener solvent at 80 °C within 30-45 min. Materials with different percentages of Bi2O3 on ZrO2 were prepared by simple wet impregnation method. The synthesized material has been characterized by various techniques (XRD, TEM, SEM, BET). 2.5% Bi2O3/ZrO2 proved superior catalyst. The Bi2O3/ZrO2 catalyst is easily recoverable and reused up to sixth run with no loss of activity. Excellent yields, short reaction time, avoidance of hazardous solvents, and no need for chromatographic purifications are the proven advantages. SN - 1573-501X UR - https://www.unboundmedicine.com/medline/citation/31098860/Efficient_synthesis_of_novel_pyrazole_linked_124_triazolidine_3_thiones_using_bismuth_on_zirconium_oxide_as_a_recyclable_catalyst_in_aqueous_medium_ L2 - https://doi.org/10.1007/s11030-019-09957-0 DB - PRIME DP - Unbound Medicine ER -
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