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Costs of isocyanate-related occupational diseases: A systematic review.
J Occup Environ Hyg 2019; 16(7):446-466JO

Abstract

Although isocyanates are increasingly used in manufacturing and workplace exposure to isocyanates is widely recognized as one of the most frequent causes for occupational lung and skin diseases, little is known about the economic burden on the affected individual and the society. This study provides an overview on costs of occupational diseases related to isocyanates. We performed a systematic literature search of studies in the electronic databases of the German Institute of Medical Documentation and Information, and the Canadian Centre for Occupational Health and Safety. We extracted the key characteristics of the studies and performed a study quality assessment. We identified eight studies on the costs of illness, of which five focused on occupational lung diseases and three on occupational skin diseases. Further, eight studies calculated loss of income/compensation payments. Out of the 16 identified articles, only two reported costs directly attributable to isocyanate-induced diseases (asthma). Studies were hardly comparable because they differed substantially in their methodological approaches. Moreover, the quality assessment of the studies revealed substantial limitations. While a wide range of isocyanate-related costs was identified, consequences of isocyanate-related occupational diseases were considerable in terms of societal costs and loss of income. In most studies, indirect costs were the main cost driver. There is a need for high-quality cost of illness studies on isocyanate-induced diseases stratified by degree of severity and sex. Such studies provide valuable information to develop preventive strategies and set priorities for measures to lower the burden of professional health risks.

Authors+Show Affiliations

a Center for Health Economics Research Hannover (CHERH) , Leibniz University Hannover , Hannover , Germany.a Center for Health Economics Research Hannover (CHERH) , Leibniz University Hannover , Hannover , Germany.b Federal Institute for Occupational Safety and Health (BAuA) , Dortmund , Germany.c Federal Institute for Occupational Safety and Health (BAuA) , Berlin , Germany.a Center for Health Economics Research Hannover (CHERH) , Leibniz University Hannover , Hannover , Germany.a Center for Health Economics Research Hannover (CHERH) , Leibniz University Hannover , Hannover , Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31100044

Citation

Kreis, Kristine, et al. "Costs of Isocyanate-related Occupational Diseases: a Systematic Review." Journal of Occupational and Environmental Hygiene, vol. 16, no. 7, 2019, pp. 446-466.
Kreis K, Aumann-Suslin I, Lüdeke A, et al. Costs of isocyanate-related occupational diseases: A systematic review. J Occup Environ Hyg. 2019;16(7):446-466.
Kreis, K., Aumann-Suslin, I., Lüdeke, A., Wegewitz, U., Zeidler, J., & Graf von der Schulenburg, J. M. (2019). Costs of isocyanate-related occupational diseases: A systematic review. Journal of Occupational and Environmental Hygiene, 16(7), pp. 446-466. doi:10.1080/15459624.2019.1609005.
Kreis K, et al. Costs of Isocyanate-related Occupational Diseases: a Systematic Review. J Occup Environ Hyg. 2019;16(7):446-466. PubMed PMID: 31100044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Costs of isocyanate-related occupational diseases: A systematic review. AU - Kreis,Kristine, AU - Aumann-Suslin,Ines, AU - Lüdeke,Andreas, AU - Wegewitz,Uta, AU - Zeidler,Jan, AU - Graf von der Schulenburg,J-Matthias, Y1 - 2019/05/17/ PY - 2019/5/18/pubmed PY - 2019/5/18/medline PY - 2019/5/18/entrez KW - Costs of illness KW - economic consequences KW - isocyanates KW - loss of income KW - occupational attributable health costs KW - occupational respiratory disease KW - occupational skin diseases SP - 446 EP - 466 JF - Journal of occupational and environmental hygiene JO - J Occup Environ Hyg VL - 16 IS - 7 N2 - Although isocyanates are increasingly used in manufacturing and workplace exposure to isocyanates is widely recognized as one of the most frequent causes for occupational lung and skin diseases, little is known about the economic burden on the affected individual and the society. This study provides an overview on costs of occupational diseases related to isocyanates. We performed a systematic literature search of studies in the electronic databases of the German Institute of Medical Documentation and Information, and the Canadian Centre for Occupational Health and Safety. We extracted the key characteristics of the studies and performed a study quality assessment. We identified eight studies on the costs of illness, of which five focused on occupational lung diseases and three on occupational skin diseases. Further, eight studies calculated loss of income/compensation payments. Out of the 16 identified articles, only two reported costs directly attributable to isocyanate-induced diseases (asthma). Studies were hardly comparable because they differed substantially in their methodological approaches. Moreover, the quality assessment of the studies revealed substantial limitations. While a wide range of isocyanate-related costs was identified, consequences of isocyanate-related occupational diseases were considerable in terms of societal costs and loss of income. In most studies, indirect costs were the main cost driver. There is a need for high-quality cost of illness studies on isocyanate-induced diseases stratified by degree of severity and sex. Such studies provide valuable information to develop preventive strategies and set priorities for measures to lower the burden of professional health risks. SN - 1545-9632 UR - https://www.unboundmedicine.com/medline/citation/31100044/Costs_of_isocyanate-related_occupational_diseases:_A_systematic_review L2 - http://www.tandfonline.com/doi/full/10.1080/15459624.2019.1609005 DB - PRIME DP - Unbound Medicine ER -