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Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: A Case-Control Study.
Ophthalmic Surg Lasers Imaging Retina. 2019 05 01; 50(5):288-294.OS

Abstract

BACKGROUND AND OBJECTIVE

To determine factors causing inflammation after intravitreal aflibercept injections.

PATIENTS AND METHODS

This case-control study included aflibercept-treated eyes with inflammation post-injection and aflibercept-treated control eyes. Medical records were analyzed to identify contributing factors. Biophysical tests were performed to characterize properties of particle aggregation. Institutional review board approval was obtained.

RESULTS

Inflammation developed in six eyes; three patients had anterior uveitis, and five had vitreous cells. Oil droplets were seen in all cases. Saldanha Rodrigues (SR) syringes were used in all cases. Among controls, SR and Becton-Dickinson syringes were used in 10 and 17 eyes, respectively. Regression analysis showed an association between SR syringes and inflammation (odds ratio = 21.66; 95% confidence interval, 1.10-425.06; P = .043). Biophysical analyses primarily showed aggregation possibly from free oil droplets or protein-oil droplet aggregation.

CONCLUSIONS

Post-injection inflammation was associated with SR syringes. Silicone oil droplets, especially after syringe agitation, might play a role in the inflammatory reaction. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:288-294.].

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31100159

Citation

Melo, Gustavo Barreto, et al. "Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: a Case-Control Study." Ophthalmic Surgery, Lasers & Imaging Retina, vol. 50, no. 5, 2019, pp. 288-294.
Melo GB, Figueira ACM, Batista FAH, et al. Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: A Case-Control Study. Ophthalmic Surg Lasers Imaging Retina. 2019;50(5):288-294.
Melo, G. B., Figueira, A. C. M., Batista, F. A. H., Filho, A. A. S. L., Rodrigues, E. B., Belfort, R., & Maia, M. (2019). Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: A Case-Control Study. Ophthalmic Surgery, Lasers & Imaging Retina, 50(5), 288-294. https://doi.org/10.3928/23258160-20190503-05
Melo GB, et al. Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: a Case-Control Study. Ophthalmic Surg Lasers Imaging Retina. 2019 05 1;50(5):288-294. PubMed PMID: 31100159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory Reaction After Aflibercept Intravitreal Injections Associated With Silicone Oil Droplets Released From Syringes: A Case-Control Study. AU - Melo,Gustavo Barreto, AU - Figueira,Ana Carolina Migliorini, AU - Batista,Fernanda Aparecida Heleno, AU - Filho,Acácio Alves Souza Lima, AU - Rodrigues,Eduardo Büchele, AU - Belfort,Rubens,Jr AU - Maia,Maurício, PY - 2018/07/31/received PY - 2018/12/19/accepted PY - 2019/5/18/entrez PY - 2019/5/18/pubmed PY - 2019/5/18/medline SP - 288 EP - 294 JF - Ophthalmic surgery, lasers & imaging retina JO - Ophthalmic Surg Lasers Imaging Retina VL - 50 IS - 5 N2 - BACKGROUND AND OBJECTIVE: To determine factors causing inflammation after intravitreal aflibercept injections. PATIENTS AND METHODS: This case-control study included aflibercept-treated eyes with inflammation post-injection and aflibercept-treated control eyes. Medical records were analyzed to identify contributing factors. Biophysical tests were performed to characterize properties of particle aggregation. Institutional review board approval was obtained. RESULTS: Inflammation developed in six eyes; three patients had anterior uveitis, and five had vitreous cells. Oil droplets were seen in all cases. Saldanha Rodrigues (SR) syringes were used in all cases. Among controls, SR and Becton-Dickinson syringes were used in 10 and 17 eyes, respectively. Regression analysis showed an association between SR syringes and inflammation (odds ratio = 21.66; 95% confidence interval, 1.10-425.06; P = .043). Biophysical analyses primarily showed aggregation possibly from free oil droplets or protein-oil droplet aggregation. CONCLUSIONS: Post-injection inflammation was associated with SR syringes. Silicone oil droplets, especially after syringe agitation, might play a role in the inflammatory reaction. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:288-294.]. SN - 2325-8179 UR - https://www.unboundmedicine.com/medline/citation/31100159/Inflammatory_Reaction_After_Aflibercept_Intravitreal_Injections_Associated_With_Silicone_Oil_Droplets_Released_From_Syringes:_A_Case_Control_Study_ L2 - https://www.healio.com/doiresolver?doi=10.3928/23258160-20190503-05 DB - PRIME DP - Unbound Medicine ER -