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Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats.

Abstract

Stanniocalcin-1 and -2 belong to a family of molecules that exhibit both paracrine and autocrine effects in mammalian cells. Human stanniocalcin-1 (hSTC-1) is expressed in a wide range of tissues, including white adipose tissue. In fed rats, hSTC-1 increases carbon flux from glucose to lipids in retroperitoneal white adipose tissue. Human stanniocalcin-2 (hSTC-2) is expressed in almost all tissues and regulates various biological processes. The aim of this work was to study the action of hSTC-1 and hSTC-2 in the lipid and glucose metabolism of epididymal white adipose tissue (eWAT) in rats in different nutritional states. This study shows for the first time an opposite effect of hSTC-1 and hSTC-2 on glyceride-glycerol generation from glucose in eWAT of fed rats. hSTC-1 stimulated the storage of triacylglycerol (TAG) in eWAT in the postprandial period, increasing glucose uptake and glyceride-glycerol generation from 14C-glucose. hSTC-2 decreased TAG synthesis, reducing glyceride-glycerol generation from 14C-glucose, direct phosphorylation of glycerol and fatty acid synthesis from 14C-glucose in eWAT of fed rats. However, both hormones increased glucose uptake in fed and fasting states. These findings provide evidence for a direct role of hSTC-1 and hSTC-2 in the regulation of lipid and glucose metabolism in eWAT of rats.

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  • Authors+Show Affiliations

    ,

    UFRGS, Fisiologia , Rua Sarmento Leite,500 , Porto Alegre, RS, Brazil , 90050170 ; elainesarapio@gmail.com.

    ,

    UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; samirks@hotmail.com.

    ,

    UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; pyargenta@gmail.com.

    ,

    UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; mtrapp@ufrgs.br.

    UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; roselis@ufrgs.br.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31100207

    Citation

    Sarapio, Elaine, et al. "Stanniocalcin-1 and -2 Effects On Glucose and Lipid Metabolism in White Adipose Tissue From Fed and Fasted Rats." Canadian Journal of Physiology and Pharmacology, 2019.
    Sarapio E, De Souza SK, Model JFA, et al. Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats. Can J Physiol Pharmacol. 2019.
    Sarapio, E., De Souza, S. K., Model, J. F. A., Trapp, M., & Da Silva, R. S. M. (2019). Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats. Canadian Journal of Physiology and Pharmacology, doi:10.1139/cjpp-2019-0023.
    Sarapio E, et al. Stanniocalcin-1 and -2 Effects On Glucose and Lipid Metabolism in White Adipose Tissue From Fed and Fasted Rats. Can J Physiol Pharmacol. 2019 May 17; PubMed PMID: 31100207.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats. AU - Sarapio,Elaine, AU - De Souza,Samir Khal, AU - Model,Jorge Felipe Argenta, AU - Trapp,Marcia, AU - Da Silva,Roselis Silveira Martins, Y1 - 2019/05/17/ PY - 2019/5/18/entrez PY - 2019/5/18/pubmed PY - 2019/5/18/medline JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. N2 - Stanniocalcin-1 and -2 belong to a family of molecules that exhibit both paracrine and autocrine effects in mammalian cells. Human stanniocalcin-1 (hSTC-1) is expressed in a wide range of tissues, including white adipose tissue. In fed rats, hSTC-1 increases carbon flux from glucose to lipids in retroperitoneal white adipose tissue. Human stanniocalcin-2 (hSTC-2) is expressed in almost all tissues and regulates various biological processes. The aim of this work was to study the action of hSTC-1 and hSTC-2 in the lipid and glucose metabolism of epididymal white adipose tissue (eWAT) in rats in different nutritional states. This study shows for the first time an opposite effect of hSTC-1 and hSTC-2 on glyceride-glycerol generation from glucose in eWAT of fed rats. hSTC-1 stimulated the storage of triacylglycerol (TAG) in eWAT in the postprandial period, increasing glucose uptake and glyceride-glycerol generation from 14C-glucose. hSTC-2 decreased TAG synthesis, reducing glyceride-glycerol generation from 14C-glucose, direct phosphorylation of glycerol and fatty acid synthesis from 14C-glucose in eWAT of fed rats. However, both hormones increased glucose uptake in fed and fasting states. These findings provide evidence for a direct role of hSTC-1 and hSTC-2 in the regulation of lipid and glucose metabolism in eWAT of rats. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/31100207/Stanniocalcin-1_and_-2_effects_on_glucose_and_lipid_metabolism_in_white_adipose_tissue_from_fed_and_fasted_rats L2 - http://www.nrcresearchpress.com/doi/full/10.1139/cjpp-2019-0023?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -