Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats.
Stanniocalcin-1 and -2 belong to a family of molecules that exhibit both paracrine and autocrine effects in mammalian cells. Human stanniocalcin-1 (hSTC-1) is expressed in a wide range of tissues, including white adipose tissue. In fed rats, hSTC-1 increases carbon flux from glucose to lipids in retroperitoneal white adipose tissue. Human stanniocalcin-2 (hSTC-2) is expressed in almost all tissues and regulates various biological processes. The aim of this work was to study the action of hSTC-1 and hSTC-2 in the lipid and glucose metabolism of epididymal white adipose tissue (eWAT) in rats in different nutritional states. This study shows for the first time an opposite effect of hSTC-1 and hSTC-2 on glyceride-glycerol generation from glucose in eWAT of fed rats. hSTC-1 stimulated the storage of triacylglycerol (TAG) in eWAT in the postprandial period, increasing glucose uptake and glyceride-glycerol generation from 14C-glucose. hSTC-2 decreased TAG synthesis, reducing glyceride-glycerol generation from 14C-glucose, direct phosphorylation of glycerol and fatty acid synthesis from 14C-glucose in eWAT of fed rats. However, both hormones increased glucose uptake in fed and fasting states. These findings provide evidence for a direct role of hSTC-1 and hSTC-2 in the regulation of lipid and glucose metabolism in eWAT of rats.
UFRGS, Fisiologia , Rua Sarmento Leite,500 , Porto Alegre, RS, Brazil , 90050170 ; firstname.lastname@example.org.,
UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; email@example.com.,
UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; firstname.lastname@example.org.,
UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; email@example.com.
UFRGS, Fisiologia, Porto Alegre, RS, Brazil ; firstname.lastname@example.org.
Pub Type(s)Journal Article