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Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort.
Environ Sci Pollut Res Int 2019; 26(20):20780-20786ES

Abstract

The purpose of this study was to investigate the longitudinal effects of perinatal exposure to dioxin on physical growth in a 3-year follow-up study. In 2015, 27 mother-infant pairs living in an electronic waste (e-waste) dismantling region and 35 pairs living in a control region were enrolled in the present study. Breast milk samples were collected at 4 weeks after birth. Physical growth, including weight, height, and head and chest circumferences, was measured at 6 months and 3 years of age. Dioxin levels in the breast milk were measured by gas chromatography/high-resolution mass spectrometry. Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and toxic equivalency values in maternal breast milk of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCDDs/PCDFs were significantly higher in women residing in the e-waste dismantling region. In 3-year-old boys, inverse associations were found between height and PCDDs-TEQ. In girls, positive associations were found between height and 2,3,7,8-TetraCDD, PCDDs-TEQ, and PCDDs/PCDFs-TEQ, and for weight and PCDDs-TEQ and PCDDs/PCDFs-TEQ at 3 years of age. In this study, sex-specific differences were observed in children, in whom dioxin exposure decreased growth in boys but increased growth in girls during the first 3 years of life.

Authors+Show Affiliations

Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.Taizhou Enze Medical Center Enze Hospital, Taizhou, Zhejiang, China.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.The Second Hospital of Jiaxing, Jiaxing, Zhejiang, China.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China. syh9012881999@163.com. Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan. syh9012881999@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31102233

Citation

Wang, Zheng, et al. "Effects of Perinatal Dioxin Exposure On Development of Children: a 3-year Follow-up Study of China Cohort." Environmental Science and Pollution Research International, vol. 26, no. 20, 2019, pp. 20780-20786.
Wang Z, Hang JG, Feng H, et al. Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort. Environ Sci Pollut Res Int. 2019;26(20):20780-20786.
Wang, Z., Hang, J. G., Feng, H., Shi, L. L., Dong, J. J., Shen, B., ... Sun, X. L. (2019). Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort. Environmental Science and Pollution Research International, 26(20), pp. 20780-20786. doi:10.1007/s11356-019-05362-0.
Wang Z, et al. Effects of Perinatal Dioxin Exposure On Development of Children: a 3-year Follow-up Study of China Cohort. Environ Sci Pollut Res Int. 2019;26(20):20780-20786. PubMed PMID: 31102233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort. AU - Wang,Zheng, AU - Hang,Jin Guo, AU - Feng,Hao, AU - Shi,Li Li, AU - Dong,Jing Jian, AU - Shen,Bin, AU - Luo,Ting, AU - Cai,Ren Mei, AU - Shen,Ling Jie, AU - Kido,Teruhiko, AU - Sun,Xian Liang, Y1 - 2019/05/18/ PY - 2018/12/02/received PY - 2019/05/02/accepted PY - 2019/5/19/pubmed PY - 2019/10/15/medline PY - 2019/5/19/entrez KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin KW - Breast milk KW - E-waste KW - Physical growth KW - Polychlorinated dibenzo-p-dioxins KW - Polychlorinated dibenzofurans KW - Sex-specific SP - 20780 EP - 20786 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 20 N2 - The purpose of this study was to investigate the longitudinal effects of perinatal exposure to dioxin on physical growth in a 3-year follow-up study. In 2015, 27 mother-infant pairs living in an electronic waste (e-waste) dismantling region and 35 pairs living in a control region were enrolled in the present study. Breast milk samples were collected at 4 weeks after birth. Physical growth, including weight, height, and head and chest circumferences, was measured at 6 months and 3 years of age. Dioxin levels in the breast milk were measured by gas chromatography/high-resolution mass spectrometry. Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and toxic equivalency values in maternal breast milk of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCDDs/PCDFs were significantly higher in women residing in the e-waste dismantling region. In 3-year-old boys, inverse associations were found between height and PCDDs-TEQ. In girls, positive associations were found between height and 2,3,7,8-TetraCDD, PCDDs-TEQ, and PCDDs/PCDFs-TEQ, and for weight and PCDDs-TEQ and PCDDs/PCDFs-TEQ at 3 years of age. In this study, sex-specific differences were observed in children, in whom dioxin exposure decreased growth in boys but increased growth in girls during the first 3 years of life. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31102233/Effects_of_perinatal_dioxin_exposure_on_development_of_children:_a_3-year_follow-up_study_of_China_cohort L2 - https://dx.doi.org/10.1007/s11356-019-05362-0 DB - PRIME DP - Unbound Medicine ER -