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Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort.

Abstract

The purpose of this study was to investigate the longitudinal effects of perinatal exposure to dioxin on physical growth in a 3-year follow-up study. In 2015, 27 mother-infant pairs living in an electronic waste (e-waste) dismantling region and 35 pairs living in a control region were enrolled in the present study. Breast milk samples were collected at 4 weeks after birth. Physical growth, including weight, height, and head and chest circumferences, was measured at 6 months and 3 years of age. Dioxin levels in the breast milk were measured by gas chromatography/high-resolution mass spectrometry. Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and toxic equivalency values in maternal breast milk of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCDDs/PCDFs were significantly higher in women residing in the e-waste dismantling region. In 3-year-old boys, inverse associations were found between height and PCDDs-TEQ. In girls, positive associations were found between height and 2,3,7,8-TetraCDD, PCDDs-TEQ, and PCDDs/PCDFs-TEQ, and for weight and PCDDs-TEQ and PCDDs/PCDFs-TEQ at 3 years of age. In this study, sex-specific differences were observed in children, in whom dioxin exposure decreased growth in boys but increased growth in girls during the first 3 years of life.

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  • Authors+Show Affiliations

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    Taizhou Enze Medical Center Enze Hospital, Taizhou, Zhejiang, China.

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    The Second Hospital of Jiaxing, Jiaxing, Zhejiang, China.

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    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China.

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    Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan.

    Department of Public Health, School of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang, 314-001, China. syh9012881999@163.com. Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan. syh9012881999@163.com.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31102233

    Citation

    Wang, Zheng, et al. "Effects of Perinatal Dioxin Exposure On Development of Children: a 3-year Follow-up Study of China Cohort." Environmental Science and Pollution Research International, 2019.
    Wang Z, Hang JG, Feng H, et al. Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort. Environ Sci Pollut Res Int. 2019.
    Wang, Z., Hang, J. G., Feng, H., Shi, L. L., Dong, J. J., Shen, B., ... Sun, X. L. (2019). Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort. Environmental Science and Pollution Research International, doi:10.1007/s11356-019-05362-0.
    Wang Z, et al. Effects of Perinatal Dioxin Exposure On Development of Children: a 3-year Follow-up Study of China Cohort. Environ Sci Pollut Res Int. 2019 May 18; PubMed PMID: 31102233.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort. AU - Wang,Zheng, AU - Hang,Jin Guo, AU - Feng,Hao, AU - Shi,Li Li, AU - Dong,Jing Jian, AU - Shen,Bin, AU - Luo,Ting, AU - Cai,Ren Mei, AU - Shen,Ling Jie, AU - Kido,Teruhiko, AU - Sun,Xian Liang, Y1 - 2019/05/18/ PY - 2018/12/02/received PY - 2019/05/02/accepted PY - 2019/5/19/entrez KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin KW - Breast milk KW - E-waste KW - Physical growth KW - Polychlorinated dibenzo-p-dioxins KW - Polychlorinated dibenzofurans KW - Sex-specific JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int N2 - The purpose of this study was to investigate the longitudinal effects of perinatal exposure to dioxin on physical growth in a 3-year follow-up study. In 2015, 27 mother-infant pairs living in an electronic waste (e-waste) dismantling region and 35 pairs living in a control region were enrolled in the present study. Breast milk samples were collected at 4 weeks after birth. Physical growth, including weight, height, and head and chest circumferences, was measured at 6 months and 3 years of age. Dioxin levels in the breast milk were measured by gas chromatography/high-resolution mass spectrometry. Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and toxic equivalency values in maternal breast milk of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and PCDDs/PCDFs were significantly higher in women residing in the e-waste dismantling region. In 3-year-old boys, inverse associations were found between height and PCDDs-TEQ. In girls, positive associations were found between height and 2,3,7,8-TetraCDD, PCDDs-TEQ, and PCDDs/PCDFs-TEQ, and for weight and PCDDs-TEQ and PCDDs/PCDFs-TEQ at 3 years of age. In this study, sex-specific differences were observed in children, in whom dioxin exposure decreased growth in boys but increased growth in girls during the first 3 years of life. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31102233/Effects_of_perinatal_dioxin_exposure_on_development_of_children:_a_3-year_follow-up_study_of_China_cohort L2 - https://dx.doi.org/10.1007/s11356-019-05362-0 DB - PRIME DP - Unbound Medicine ER -