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Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people.
Eur J Neurol. 2019 11; 26(11):1362-1369.EJ

Abstract

BACKGROUND AND PURPOSE

The aim of this study was to determine the effects of apolipoprotein E ε4 (APOE ε4) genotype and sex together on longitudinal change in adjusted hippocampal volume [hippocampal volume:intracranial volume ratio (HpVR)] across the Alzheimer's disease (AD) continuum.

METHODS

At baseline, we included 372 individuals with normal cognition (NC), 738 individuals with mild cognitive impairment (MCI) and 271 patients with mild AD from the Alzheimer's Disease Neuroimaging Initiative database. We examined the effects of the APOE ε4 by sex interaction on longitudinal change in HpVR within the overall sample and within each diagnostic group.

RESULTS

Female gender was found to be associated with longitudinal reduction of HpVR in the NC and MCI groups, but not in the AD group. Similarly, APOE ε4 was associated with longitudinal reduction of HpVR in the NC and MCI groups, but not in the AD group. Further, female APOE ε4 carriers showed a greater longitudinal reduction of HpVR than their male counterparts in the NC group, but not in the MCI or AD group. However, due to the relatively short duration of follow-up visits in patients with AD, further studies are needed to replicate these findings.

CONCLUSION

Female APOE ε4 carriers show a greater longitudinal reduction of HpVR than their male counterparts in cognitively normal older adults.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Shen S
Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Zhou W
Department of Pathology, Hangzhou Normal University, Hangzhou, China.
Chen X
Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Zhang J
Independent researcher, Hangzhou, China.
for Alzheimer's Disease Neuroimaging Initiative
No affiliation info available

MeSH

AgedAged, 80 and overAgingAlzheimer DiseaseApolipoprotein E4AtrophyCognitionCognitive DysfunctionFemaleGenotypeHippocampusHumansLongitudinal StudiesMaleMiddle AgedNeuroimagingReference ValuesSex Characteristics

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31102429

Citation

Shen, S, et al. "Sex Differences in the Association of APOE Ε4 Genotype With Longitudinal Hippocampal Atrophy in Cognitively Normal Older People." European Journal of Neurology, vol. 26, no. 11, 2019, pp. 1362-1369.
Shen S, Zhou W, Chen X, et al. Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people. Eur J Neurol. 2019;26(11):1362-1369.
Shen, S., Zhou, W., Chen, X., & Zhang, J. (2019). Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people. European Journal of Neurology, 26(11), 1362-1369. https://doi.org/10.1111/ene.13987
Shen S, et al. Sex Differences in the Association of APOE Ε4 Genotype With Longitudinal Hippocampal Atrophy in Cognitively Normal Older People. Eur J Neurol. 2019;26(11):1362-1369. PubMed PMID: 31102429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people. AU - Shen,S, AU - Zhou,W, AU - Chen,X, AU - Zhang,J, AU - ,, Y1 - 2019/06/24/ PY - 2018/12/11/received PY - 2019/05/13/accepted PY - 2019/5/19/pubmed PY - 2020/7/21/medline PY - 2019/5/19/entrez KW - apolipoprotein E ε4 KW - magnetic resonance imaging KW - Alzheimer's disease KW - hippocampal atrophy KW - sex difference SP - 1362 EP - 1369 JF - European journal of neurology JO - Eur J Neurol VL - 26 IS - 11 N2 - BACKGROUND AND PURPOSE: The aim of this study was to determine the effects of apolipoprotein E ε4 (APOE ε4) genotype and sex together on longitudinal change in adjusted hippocampal volume [hippocampal volume:intracranial volume ratio (HpVR)] across the Alzheimer's disease (AD) continuum. METHODS: At baseline, we included 372 individuals with normal cognition (NC), 738 individuals with mild cognitive impairment (MCI) and 271 patients with mild AD from the Alzheimer's Disease Neuroimaging Initiative database. We examined the effects of the APOE ε4 by sex interaction on longitudinal change in HpVR within the overall sample and within each diagnostic group. RESULTS: Female gender was found to be associated with longitudinal reduction of HpVR in the NC and MCI groups, but not in the AD group. Similarly, APOE ε4 was associated with longitudinal reduction of HpVR in the NC and MCI groups, but not in the AD group. Further, female APOE ε4 carriers showed a greater longitudinal reduction of HpVR than their male counterparts in the NC group, but not in the MCI or AD group. However, due to the relatively short duration of follow-up visits in patients with AD, further studies are needed to replicate these findings. CONCLUSION: Female APOE ε4 carriers show a greater longitudinal reduction of HpVR than their male counterparts in cognitively normal older adults. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/31102429/Sex_differences_in_the_association_of_APOE_ε4_genotype_with_longitudinal_hippocampal_atrophy_in_cognitively_normal_older_people_ DB - PRIME DP - Unbound Medicine ER -