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Lab-on-nanopaper: An optical sensing bioplatform based on curcumin embedded in bacterial nanocellulose as an albumin assay kit.
Anal Chim Acta. 2019 Sep 06; 1070:104-111.AC

Abstract

Herein, we introduce a nanopaper-based analytical device (NAD) or "lab-on-nanopaper" device for visual sensing of human serum albumin (HSA) in human blood serums, which relies on embedding of curcumin within transparent bacterial cellulose (BC) nanopaper. BC nanopaper is an appropriate candidate to be an excellent platform for the development of optical (bio)sensors due to having exceptional properties such as optical transparency, high flexibility, porosity, biodegradability, and printability. The hydrophilic test zones were created on the fabricated bioplatform through creating the hydrophobic walls via laser printing technology. The color changes of curcumin embedded in BC nanopaper (CEBC) due to the inhibitory effect of HSA on the curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a spectrophotometer, were linearly proportional to the HSA concentration in the range of 10-300 μM and 25-400 μM, respectively. The developed NAD/CEBC as a novel albumin assay kit was successfully utilized to the determination of HSA in human blood serum samples with satisfactory results. Building upon the fascinating features of BC nanopaper as a very promising bioplatform in optical (bio)sensing applications we are confident "lab-on-nanopaper" devices/NADs, which take the advantages of the nanopaper and also meet the ASSURED criteria, could be considered as a new generation of optical (bio)sensing platforms that are currently based on paper, glass or plastic substrates.

Authors+Show Affiliations

Chemistry and Chemical Engineering Research Center of Iran, 14335-186, Tehran, Iran.Chemistry and Chemical Engineering Research Center of Iran, 14335-186, Tehran, Iran. Electronic address: golmohammadi@ccerci.ac.ir.Chemistry and Chemical Engineering Research Center of Iran, 14335-186, Tehran, Iran.Environmental Protection Agency of Khuzestan, Ahvaz, Iran.Chemistry and Chemical Engineering Research Center of Iran, 14335-186, Tehran, Iran.Chemistry and Chemical Engineering Research Center of Iran, 14335-186, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31103163

Citation

Naghdi, Tina, et al. "Lab-on-nanopaper: an Optical Sensing Bioplatform Based On Curcumin Embedded in Bacterial Nanocellulose as an Albumin Assay Kit." Analytica Chimica Acta, vol. 1070, 2019, pp. 104-111.
Naghdi T, Golmohammadi H, Vosough M, et al. Lab-on-nanopaper: An optical sensing bioplatform based on curcumin embedded in bacterial nanocellulose as an albumin assay kit. Anal Chim Acta. 2019;1070:104-111.
Naghdi, T., Golmohammadi, H., Vosough, M., Atashi, M., Saeedi, I., & Maghsoudi, M. T. (2019). Lab-on-nanopaper: An optical sensing bioplatform based on curcumin embedded in bacterial nanocellulose as an albumin assay kit. Analytica Chimica Acta, 1070, 104-111. https://doi.org/10.1016/j.aca.2019.04.037
Naghdi T, et al. Lab-on-nanopaper: an Optical Sensing Bioplatform Based On Curcumin Embedded in Bacterial Nanocellulose as an Albumin Assay Kit. Anal Chim Acta. 2019 Sep 6;1070:104-111. PubMed PMID: 31103163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lab-on-nanopaper: An optical sensing bioplatform based on curcumin embedded in bacterial nanocellulose as an albumin assay kit. AU - Naghdi,Tina, AU - Golmohammadi,Hamed, AU - Vosough,Maryam, AU - Atashi,Mojgan, AU - Saeedi,Iman, AU - Maghsoudi,Mohammad Taghi, Y1 - 2019/04/20/ PY - 2018/12/30/received PY - 2019/04/08/revised PY - 2019/04/16/accepted PY - 2019/5/20/entrez PY - 2019/5/20/pubmed PY - 2019/6/22/medline KW - Albumin KW - Bacterial cellulose nanopaper KW - Curcumin KW - Optical sensor SP - 104 EP - 111 JF - Analytica chimica acta JO - Anal. Chim. Acta VL - 1070 N2 - Herein, we introduce a nanopaper-based analytical device (NAD) or "lab-on-nanopaper" device for visual sensing of human serum albumin (HSA) in human blood serums, which relies on embedding of curcumin within transparent bacterial cellulose (BC) nanopaper. BC nanopaper is an appropriate candidate to be an excellent platform for the development of optical (bio)sensors due to having exceptional properties such as optical transparency, high flexibility, porosity, biodegradability, and printability. The hydrophilic test zones were created on the fabricated bioplatform through creating the hydrophobic walls via laser printing technology. The color changes of curcumin embedded in BC nanopaper (CEBC) due to the inhibitory effect of HSA on the curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a spectrophotometer, were linearly proportional to the HSA concentration in the range of 10-300 μM and 25-400 μM, respectively. The developed NAD/CEBC as a novel albumin assay kit was successfully utilized to the determination of HSA in human blood serum samples with satisfactory results. Building upon the fascinating features of BC nanopaper as a very promising bioplatform in optical (bio)sensing applications we are confident "lab-on-nanopaper" devices/NADs, which take the advantages of the nanopaper and also meet the ASSURED criteria, could be considered as a new generation of optical (bio)sensing platforms that are currently based on paper, glass or plastic substrates. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/31103163/Lab_on_nanopaper:_An_optical_sensing_bioplatform_based_on_curcumin_embedded_in_bacterial_nanocellulose_as_an_albumin_assay_kit_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(19)30471-4 DB - PRIME DP - Unbound Medicine ER -