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Ameliorative effect of Spirulina platensis against lead nitrate-induced cytotoxicity and genotoxicity in catfish Clarias gariepinus.
Environ Sci Pollut Res Int. 2019 Jul; 26(20):20610-20618.ES

Abstract

The present study was designed to investigate the protective role of dietary supplementation of Spirulina platensis (SP) against cytotoxic and genotoxic effects of lead nitrate in Clarias gariepinus. Four groups of fishes were used: first group as control which fed on basal diet, second group fed on basal diet and exposed to (1 mg/L of lead nitrate), third group fed on diet containing 0.25% SP and exposed to (1 mg/L of lead nitrate), and fourth group fed on diet containing 0.5%SP and exposed to (1 mg/L of lead nitrate). Fish samples were taken at 2nd and 4th week of exposure. The hematological indices of lead nitrate-exposed group were decreased significantly compared to the control group at 2nd and 4th week of exposure. Lead nitrate caused a significant increase in the percentage of poikilocytosis, micronuclei, and apoptotic cells as well as comet tail length and olive tail moment compared with the control group at 2nd and 4th week of exposure. The highest level of damage was found on 4th week of exposure with all parameters. Dietary inclusion of SP ameliorated these cytotoxic and genetic changes, as well as this amelioration was concentration and time dependent. Consequently, the present study proposed that the addition of SP to the fish diet can be used as a promising protective agent to oppose cytotoxic and genotoxic effects of lead nitrate in aquaculture. Graphical abstract.

Authors+Show Affiliations

Department of Zoology, Faculty of Science, Al Azhar University (Assiut Branch), Assiut, 71524, Egypt.Department of Zoology, Faculty of Science, Sohag University, Sohag, 8562, Egypt.Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt. alaasayed@aun.edu.eg.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31104244

Citation

Hamed, Mohamed, et al. "Ameliorative Effect of Spirulina Platensis Against Lead Nitrate-induced Cytotoxicity and Genotoxicity in Catfish Clarias Gariepinus." Environmental Science and Pollution Research International, vol. 26, no. 20, 2019, pp. 20610-20618.
Hamed M, Soliman HAM, Sayed AEH. Ameliorative effect of Spirulina platensis against lead nitrate-induced cytotoxicity and genotoxicity in catfish Clarias gariepinus. Environ Sci Pollut Res Int. 2019;26(20):20610-20618.
Hamed, M., Soliman, H. A. M., & Sayed, A. E. H. (2019). Ameliorative effect of Spirulina platensis against lead nitrate-induced cytotoxicity and genotoxicity in catfish Clarias gariepinus. Environmental Science and Pollution Research International, 26(20), 20610-20618. https://doi.org/10.1007/s11356-019-05319-3
Hamed M, Soliman HAM, Sayed AEH. Ameliorative Effect of Spirulina Platensis Against Lead Nitrate-induced Cytotoxicity and Genotoxicity in Catfish Clarias Gariepinus. Environ Sci Pollut Res Int. 2019;26(20):20610-20618. PubMed PMID: 31104244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effect of Spirulina platensis against lead nitrate-induced cytotoxicity and genotoxicity in catfish Clarias gariepinus. AU - Hamed,Mohamed, AU - Soliman,Hamdy A M, AU - Sayed,Alaa El-Din H, Y1 - 2019/05/18/ PY - 2018/12/25/received PY - 2019/04/30/accepted PY - 2019/5/20/pubmed PY - 2019/9/11/medline PY - 2019/5/20/entrez KW - Apoptosis KW - Lead nitrate KW - MN KW - Poikilocytosis KW - Spirulina KW - Tail moment SP - 20610 EP - 20618 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 26 IS - 20 N2 - The present study was designed to investigate the protective role of dietary supplementation of Spirulina platensis (SP) against cytotoxic and genotoxic effects of lead nitrate in Clarias gariepinus. Four groups of fishes were used: first group as control which fed on basal diet, second group fed on basal diet and exposed to (1 mg/L of lead nitrate), third group fed on diet containing 0.25% SP and exposed to (1 mg/L of lead nitrate), and fourth group fed on diet containing 0.5%SP and exposed to (1 mg/L of lead nitrate). Fish samples were taken at 2nd and 4th week of exposure. The hematological indices of lead nitrate-exposed group were decreased significantly compared to the control group at 2nd and 4th week of exposure. Lead nitrate caused a significant increase in the percentage of poikilocytosis, micronuclei, and apoptotic cells as well as comet tail length and olive tail moment compared with the control group at 2nd and 4th week of exposure. The highest level of damage was found on 4th week of exposure with all parameters. Dietary inclusion of SP ameliorated these cytotoxic and genetic changes, as well as this amelioration was concentration and time dependent. Consequently, the present study proposed that the addition of SP to the fish diet can be used as a promising protective agent to oppose cytotoxic and genotoxic effects of lead nitrate in aquaculture. Graphical abstract. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31104244/Ameliorative_effect_of_Spirulina_platensis_against_lead_nitrate_induced_cytotoxicity_and_genotoxicity_in_catfish_Clarias_gariepinus_ DB - PRIME DP - Unbound Medicine ER -