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Appropriateness of clinical criteria for the use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). A Delphi Method Consensus initiative among experts in Italy.
Eur J Phys Rehabil Med 2019; 55(5):658-664EJ

Abstract

BACKGROUND

Osteoarthritis (OA) is a theme currently representing an emerging topic for its increasing incidence. It is well known that it is a chronic disease that could lead to important long-lasting disability; this generates increasing costs for the health care system. OA treatment options vary: localization, etiology, grading and symptomatology should be considered before choosing the most adequate therapy. Currently, a modern approach to managing OA involves SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOAs). However, while all preparations may claim to deliver a therapeutic level of glucosamine or chondroitin, not all of them are supported by clinical evidence. Recently the European Society for Clinical and Economic aspects of Osteoporosis, Osteoarthritis and musculoskeletal diseases (ESCEO), produced an evidenced based document providing practitioners with the latest clinical and economic information, thereby allowing them to optimize the management of knee OA. According to this report, only crystalline glucosamine sulphate and the pharmaceutical-grade chondroitin sulphate are considered as effective in the first line approach to treating knee OA as an alternative drug to acetaminophen. However, some OA guidelines do not agree are not concordant in recommending the use of SYSADOA, perhaps because they are generally considered as a class and distinctions among formulations are not made.

AIM

Aim of this study was to identify the main aspects involved in patient selection, the choice of therapeutic agents and the safety profile in using SYSADOA.

DESIGN

Delphi method Consenus Statement.

POPULATION

Italian Physicians having expertise in Osteoarthritis management.

METHODS

A committee of 11 experts from Italian universities, public hospitals, territorial services, research institutes and patient associations was set up. Sixty-three clinicians from a large number of Italian medical centers specialized in osteoarthritis management took part in a Delphi process which was aimed at obtaining consensus statements among the participants.

RESULTS

Large consensus was obtained for statements grouped under the following main themes: treatment indications; drug/medical devices choice; treatment efficacy.

CONCLUSIONS

Results from the Italian consensus on appropriateness of OA therapies in osteoarthritis seems to be in line with the stepwise approach proposed by the ESCEO algorithm, where crystalline glucosamine sulphate shows greater clinical efficacy than other glucosamine-based formulations, according to several independent meta-analyses.

CLINICAL REHABILITATION IMPACT

This study may be used as a practical reference tool to help Italian physicians treat osteoarthritis patients using SYSADOA.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Sapienza University, Rome, Italy - andrea.bernetti@uniroma1.it.Department of Physical Medicine and Rehabilitation, Sapienza University, Rome, Italy.Department of Orthopedic Science, Sapienza University, Rome, Italy.Department of Physical Medicine and Rehabilitation, Sapienza University, Rome, Italy.Department of Orthopedic Science, Sapienza University, Rome, Italy.Vittorio Erspamer Department of Physiology and Pharmacology, Sapienza University, Rome, Italy. Unit of Drug Addiction and Clinical Pharmacology, Umberto I University Hospital, Sapienza University, Rome, Italy.San Pietro Fatebenefratelli Hospital, Rome, Italy.Associazione Nazionale Malati Reumatici Onlus (ANMAR), Rome, Italy.Department of Orthopedics and Traumatology, Sport Clinique, Rome, Italy.LUISS University, Rome, Italy.Unit of Rheumatology, Department of Medicine, Surgery and Neurosciences, Le Scotte Polyclinic, University of Siena, Siena, Italy.Department of Physical Medicine and Rehabilitation, Sapienza University, Rome, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31106560

Citation

Bernetti, Andrea, et al. "Appropriateness of Clinical Criteria for the Use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). a Delphi Method Consensus Initiative Among Experts in Italy." European Journal of Physical and Rehabilitation Medicine, vol. 55, no. 5, 2019, pp. 658-664.
Bernetti A, Mangone M, Villani C, et al. Appropriateness of clinical criteria for the use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). A Delphi Method Consensus initiative among experts in Italy. Eur J Phys Rehabil Med. 2019;55(5):658-664.
Bernetti, A., Mangone, M., Villani, C., Alviti, F., Valeo, M., Grassi, M. C., ... Paoloni, M. (2019). Appropriateness of clinical criteria for the use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). A Delphi Method Consensus initiative among experts in Italy. European Journal of Physical and Rehabilitation Medicine, 55(5), pp. 658-664. doi:10.23736/S1973-9087.19.05633-8.
Bernetti A, et al. Appropriateness of Clinical Criteria for the Use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). a Delphi Method Consensus Initiative Among Experts in Italy. Eur J Phys Rehabil Med. 2019;55(5):658-664. PubMed PMID: 31106560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Appropriateness of clinical criteria for the use of SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOA). A Delphi Method Consensus initiative among experts in Italy. AU - Bernetti,Andrea, AU - Mangone,Massimiliano, AU - Villani,Ciro, AU - Alviti,Federica, AU - Valeo,Massimo, AU - Grassi,Maria C, AU - Migliore,Alberto, AU - Viora,Ugo, AU - Adriani,Ezio, AU - Quirino,Nicola, AU - Fioravanti,Antonella, AU - Paoloni,Marco, Y1 - 2019/05/15/ PY - 2019/5/21/pubmed PY - 2019/5/21/medline PY - 2019/5/21/entrez SP - 658 EP - 664 JF - European journal of physical and rehabilitation medicine JO - Eur J Phys Rehabil Med VL - 55 IS - 5 N2 - BACKGROUND: Osteoarthritis (OA) is a theme currently representing an emerging topic for its increasing incidence. It is well known that it is a chronic disease that could lead to important long-lasting disability; this generates increasing costs for the health care system. OA treatment options vary: localization, etiology, grading and symptomatology should be considered before choosing the most adequate therapy. Currently, a modern approach to managing OA involves SYmptomatic Slow-Acting Drug for OsteoArthritis (SYSADOAs). However, while all preparations may claim to deliver a therapeutic level of glucosamine or chondroitin, not all of them are supported by clinical evidence. Recently the European Society for Clinical and Economic aspects of Osteoporosis, Osteoarthritis and musculoskeletal diseases (ESCEO), produced an evidenced based document providing practitioners with the latest clinical and economic information, thereby allowing them to optimize the management of knee OA. According to this report, only crystalline glucosamine sulphate and the pharmaceutical-grade chondroitin sulphate are considered as effective in the first line approach to treating knee OA as an alternative drug to acetaminophen. However, some OA guidelines do not agree are not concordant in recommending the use of SYSADOA, perhaps because they are generally considered as a class and distinctions among formulations are not made. AIM: Aim of this study was to identify the main aspects involved in patient selection, the choice of therapeutic agents and the safety profile in using SYSADOA. DESIGN: Delphi method Consenus Statement. POPULATION: Italian Physicians having expertise in Osteoarthritis management. METHODS: A committee of 11 experts from Italian universities, public hospitals, territorial services, research institutes and patient associations was set up. Sixty-three clinicians from a large number of Italian medical centers specialized in osteoarthritis management took part in a Delphi process which was aimed at obtaining consensus statements among the participants. RESULTS: Large consensus was obtained for statements grouped under the following main themes: treatment indications; drug/medical devices choice; treatment efficacy. CONCLUSIONS: Results from the Italian consensus on appropriateness of OA therapies in osteoarthritis seems to be in line with the stepwise approach proposed by the ESCEO algorithm, where crystalline glucosamine sulphate shows greater clinical efficacy than other glucosamine-based formulations, according to several independent meta-analyses. CLINICAL REHABILITATION IMPACT: This study may be used as a practical reference tool to help Italian physicians treat osteoarthritis patients using SYSADOA. SN - 1973-9095 UR - https://www.unboundmedicine.com/medline/citation/31106560/Appropriateness_of_clinical_criteria_for_the_use_of_symptomatic_slow_acting_drug_for_osteoarthritis__SYSADOA___A_Delphi_method_consensus_initiative_among_experts_in_Italy_ L2 - https://www.minervamedica.it/index2.t?show=R33Y2019N05A0658 DB - PRIME DP - Unbound Medicine ER -