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The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency.

Abstract

Hashimoto (autoimmune) thyroiditis develops much less frequently in men than in women, suggesting that androgens have a protective effect against thyroid autoimmunity. The current study was aimed at investigating whether the effect of selenomethionine on thyroid antibody titers and thyroid function tests in euthyroid men with autoimmune thyroid disease depends on testosterone levels. The study population consisted of 2 age-matched, weight-matched, and thyroid antibody titer-matched groups of euthyroid men with Hashimoto thyroiditis and testosterone deficiency: 18 patients receiving intramuscular testosterone enanthate (100 mg once weekly) and 19 testosterone-naive men. All subjects were than treated with selenomethionine (200 μg daily) for 6 months. Serum titers of thyroid antibodies, thyrotropin, free thyroid hormones, and testosterone as well as calculated parameters of thyroid homeostasis were assessed at the beginning and at the end of the study. At baseline, except for testosterone, there were no differences between the 2 treatment arms in thyroid antibody titers, serum hormone levels, or values of all calculated indices. Although selenomethionine reduced thyroid peroxidase and thyroglobulin antibody titers in both treatment arms, these effects were stronger in testosterone-treated than in testosterone-untreated men. Only in men receiving testosterone, selenomethionine altered the free thyroxine/free triiodothyronine ratio, testosterone levels, and structure parameter interference approach-GT and structure parameter interference approach-GD. Selenomethionine-induced changes in thyroid antibody titers correlated with the effect of treatment on structure parameter interference approach-GT and testosterone. The obtained results suggest that testosterone determines the strength of selenomethionine action in euthyroid men with autoimmune thyroiditis.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Paediatrics in Bytom, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31106856

Citation

Krysiak, Robert, et al. "The Effect of Selenomethionine On Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency." Journal of Clinical Pharmacology, 2019.
Krysiak R, Kowalcze K, Okopień B. The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency. J Clin Pharmacol. 2019.
Krysiak, R., Kowalcze, K., & Okopień, B. (2019). The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency. Journal of Clinical Pharmacology, doi:10.1002/jcph.1447.
Krysiak R, Kowalcze K, Okopień B. The Effect of Selenomethionine On Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency. J Clin Pharmacol. 2019 May 20; PubMed PMID: 31106856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Effect of Selenomethionine on Thyroid Autoimmunity in Euthyroid Men With Hashimoto Thyroiditis and Testosterone Deficiency. AU - Krysiak,Robert, AU - Kowalcze,Karolina, AU - Okopień,Bogusław, Y1 - 2019/05/20/ PY - 2019/02/28/received PY - 2019/04/29/accepted PY - 2019/5/21/entrez KW - selenium KW - testosterone deficiency KW - thyroid autoimmunity KW - thyroid function tests KW - treatment JF - Journal of clinical pharmacology JO - J Clin Pharmacol N2 - Hashimoto (autoimmune) thyroiditis develops much less frequently in men than in women, suggesting that androgens have a protective effect against thyroid autoimmunity. The current study was aimed at investigating whether the effect of selenomethionine on thyroid antibody titers and thyroid function tests in euthyroid men with autoimmune thyroid disease depends on testosterone levels. The study population consisted of 2 age-matched, weight-matched, and thyroid antibody titer-matched groups of euthyroid men with Hashimoto thyroiditis and testosterone deficiency: 18 patients receiving intramuscular testosterone enanthate (100 mg once weekly) and 19 testosterone-naive men. All subjects were than treated with selenomethionine (200 μg daily) for 6 months. Serum titers of thyroid antibodies, thyrotropin, free thyroid hormones, and testosterone as well as calculated parameters of thyroid homeostasis were assessed at the beginning and at the end of the study. At baseline, except for testosterone, there were no differences between the 2 treatment arms in thyroid antibody titers, serum hormone levels, or values of all calculated indices. Although selenomethionine reduced thyroid peroxidase and thyroglobulin antibody titers in both treatment arms, these effects were stronger in testosterone-treated than in testosterone-untreated men. Only in men receiving testosterone, selenomethionine altered the free thyroxine/free triiodothyronine ratio, testosterone levels, and structure parameter interference approach-GT and structure parameter interference approach-GD. Selenomethionine-induced changes in thyroid antibody titers correlated with the effect of treatment on structure parameter interference approach-GT and testosterone. The obtained results suggest that testosterone determines the strength of selenomethionine action in euthyroid men with autoimmune thyroiditis. SN - 1552-4604 UR - https://www.unboundmedicine.com/medline/citation/31106856/The_Effect_of_Selenomethionine_on_Thyroid_Autoimmunity_in_Euthyroid_Men_With_Hashimoto_Thyroiditis_and_Testosterone_Deficiency_ L2 - https://doi.org/10.1002/jcph.1447 DB - PRIME DP - Unbound Medicine ER -