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Muscle fibre activation and fatigue with low-load blood flow restricted resistance exercise-An integrative physiology review.
Acta Physiol (Oxf). 2020 01; 228(1):e13302.AP

Abstract

Blood flow-restricted resistance exercise (BFRRE) has been shown to induce increases in muscle size and strength, and continues to generate interest from both clinical and basic research points of view. The low loads employed, typically 20%-50% of the one repetition maximum, make BFRRE an attractive training modality for individuals who may not tolerate high musculoskeletal forces (eg, selected clinical patient groups such as frail old adults and patients recovering from sports injury) and/or for highly trained athletes who have reached a plateau in muscle mass and strength. It has been proposed that achieving a high degree of muscle fibre recruitment is important for inducing muscle hypertrophy with BFRRE, and the available evidence suggest that fatiguing low-load exercise during ischemic conditions can recruit both slow (type I) and fast (type II) muscle fibres. Nevertheless, closer scrutiny reveals that type II fibre activation in BFRRE has to date largely been inferred using indirect methods such as electromyography and magnetic resonance spectroscopy, while only rarely addressed using more direct methods such as measurements of glycogen stores and phosphocreatine levels in muscle fibres. Hence, considerable uncertainity exists about the specific pattern of muscle fibre activation during BFRRE. Therefore, the purpose of this narrative review was (1) to summarize the evidence on muscle fibre recruitment during BFRRE as revealed by various methods employed for determining muscle fibre usage during exercise, and (2) to discuss reported findings in light of the specific advantages and limitations associated with these methods.

Authors+Show Affiliations

Center for Health and Performance, Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.Department of Sports Sciences and Clinical Biomechanics, SDU Muscle Research Cluster (SMRC), University of Southern Denmark, Odense M, Denmark.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31108025

Citation

Wernbom, Mathias, and Per Aagaard. "Muscle Fibre Activation and Fatigue With Low-load Blood Flow Restricted Resistance exercise-An Integrative Physiology Review." Acta Physiologica (Oxford, England), vol. 228, no. 1, 2020, pp. e13302.
Wernbom M, Aagaard P. Muscle fibre activation and fatigue with low-load blood flow restricted resistance exercise-An integrative physiology review. Acta Physiol (Oxf). 2020;228(1):e13302.
Wernbom, M., & Aagaard, P. (2020). Muscle fibre activation and fatigue with low-load blood flow restricted resistance exercise-An integrative physiology review. Acta Physiologica (Oxford, England), 228(1), e13302. https://doi.org/10.1111/apha.13302
Wernbom M, Aagaard P. Muscle Fibre Activation and Fatigue With Low-load Blood Flow Restricted Resistance exercise-An Integrative Physiology Review. Acta Physiol (Oxf). 2020;228(1):e13302. PubMed PMID: 31108025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle fibre activation and fatigue with low-load blood flow restricted resistance exercise-An integrative physiology review. AU - Wernbom,Mathias, AU - Aagaard,Per, Y1 - 2019/06/18/ PY - 2019/01/10/received PY - 2019/05/12/revised PY - 2019/05/17/accepted PY - 2019/5/21/pubmed PY - 2019/5/21/medline PY - 2019/5/21/entrez KW - fatigue KW - ischemia KW - motor units KW - muscle hypertrophy KW - occlusion SP - e13302 EP - e13302 JF - Acta physiologica (Oxford, England) JO - Acta Physiol (Oxf) VL - 228 IS - 1 N2 - Blood flow-restricted resistance exercise (BFRRE) has been shown to induce increases in muscle size and strength, and continues to generate interest from both clinical and basic research points of view. The low loads employed, typically 20%-50% of the one repetition maximum, make BFRRE an attractive training modality for individuals who may not tolerate high musculoskeletal forces (eg, selected clinical patient groups such as frail old adults and patients recovering from sports injury) and/or for highly trained athletes who have reached a plateau in muscle mass and strength. It has been proposed that achieving a high degree of muscle fibre recruitment is important for inducing muscle hypertrophy with BFRRE, and the available evidence suggest that fatiguing low-load exercise during ischemic conditions can recruit both slow (type I) and fast (type II) muscle fibres. Nevertheless, closer scrutiny reveals that type II fibre activation in BFRRE has to date largely been inferred using indirect methods such as electromyography and magnetic resonance spectroscopy, while only rarely addressed using more direct methods such as measurements of glycogen stores and phosphocreatine levels in muscle fibres. Hence, considerable uncertainity exists about the specific pattern of muscle fibre activation during BFRRE. Therefore, the purpose of this narrative review was (1) to summarize the evidence on muscle fibre recruitment during BFRRE as revealed by various methods employed for determining muscle fibre usage during exercise, and (2) to discuss reported findings in light of the specific advantages and limitations associated with these methods. SN - 1748-1716 UR - https://www.unboundmedicine.com/medline/citation/31108025/Muscle_fibre_activation_and_fatigue_with_low_load_blood_flow_restricted_resistance_exercise_An_integrative_physiology_review_ L2 - https://doi.org/10.1111/apha.13302 DB - PRIME DP - Unbound Medicine ER -
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