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A comprehensive characterization of polyphenols by LC-ESI-QTOF-MS from Melipona quadrifasciata anthidioides geopropolis and their antibacterial, antioxidant and antiproliferative effects.
Nat Prod Res. 2019 May 21 [Online ahead of print]NP

Abstract

The geopropolis is a unique type of propolis produced by some stingless bee species. This product is known in folk medicine for its pharmacological properties, mainly antimicrobial and antioxidant, but there are few scientific studies that prove these properties. The objective of this study was to evaluate the phenolic composition and the antimicrobial, antioxidant and antiproliferative activities of Melipona quadrifasciata geopropolis. The phenolic characterization of the geopropolis ethanolic extract was evaluated by LC-ESI-QTOF-MS. The antimicrobial activity was carried out against Gram-positive (including multiresistant microorganisms), negative and yeast. The synergistic effect was evaluated in association with Sulfamethoxazole + Trimethoprim. DPPH, ABTS, FRAP, ORAC and HPLC on-line were used to evaluate the antioxidant activity. Antiproliferative activity was assessed by the sulforhodamine B assay. Flavonoids and phenolic acids were identified in the extract, which showed promising antimicrobial activity, partially synergistic effect and antioxidant activity.

Authors+Show Affiliations

a Department of Food and Medicine Faculty of Pharmaceutical Sciences , Federal University of Alfenas , Minas Gerais , Brazil.a Department of Food and Medicine Faculty of Pharmaceutical Sciences , Federal University of Alfenas , Minas Gerais , Brazil.No affiliation info availablea Department of Food and Medicine Faculty of Pharmaceutical Sciences , Federal University of Alfenas , Minas Gerais , Brazil.b Department of Agri-Food Industry Food and Nutrition ''Luiz de Queiroz'' College of Agriculture , University of São Paulo , São Paulo , Brazil.c Multidisciplinary Center for Chemical, Biological, and Agricultural Research University of Campinas , São Paulo , Brazil. d Faculty of Pharmaceutical Sciences , University of Campinas , São Paulo , Brazil.c Multidisciplinary Center for Chemical, Biological, and Agricultural Research University of Campinas , São Paulo , Brazil.a Department of Food and Medicine Faculty of Pharmaceutical Sciences , Federal University of Alfenas , Minas Gerais , Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31112035

Citation

Rubinho, Marina Prado, et al. "A Comprehensive Characterization of Polyphenols By LC-ESI-QTOF-MS From Melipona Quadrifasciata Anthidioides Geopropolis and Their Antibacterial, Antioxidant and Antiproliferative Effects." Natural Product Research, 2019, pp. 1-6.
Rubinho MP, de Carvalho PLN, Reis ALLE, et al. A comprehensive characterization of polyphenols by LC-ESI-QTOF-MS from Melipona quadrifasciata anthidioides geopropolis and their antibacterial, antioxidant and antiproliferative effects. Nat Prod Res. 2019.
Rubinho, M. P., de Carvalho, P. L. N., Reis, A. L. L. E., Reis, E., de Alencar, S. M., Ruiz, A. L. T. G., de Carvalho, J. E., & Ikegaki, M. (2019). A comprehensive characterization of polyphenols by LC-ESI-QTOF-MS from Melipona quadrifasciata anthidioides geopropolis and their antibacterial, antioxidant and antiproliferative effects. Natural Product Research, 1-6. https://doi.org/10.1080/14786419.2019.1607851
Rubinho MP, et al. A Comprehensive Characterization of Polyphenols By LC-ESI-QTOF-MS From Melipona Quadrifasciata Anthidioides Geopropolis and Their Antibacterial, Antioxidant and Antiproliferative Effects. Nat Prod Res. 2019 May 21;1-6. PubMed PMID: 31112035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comprehensive characterization of polyphenols by LC-ESI-QTOF-MS from Melipona quadrifasciata anthidioides geopropolis and their antibacterial, antioxidant and antiproliferative effects. AU - Rubinho,Marina Prado, AU - de Carvalho,Patrícia Lunardelli Negreiros, AU - Reis,Ana Luísa Lopes Ernesto, AU - Reis,Esto, AU - de Alencar,Severino Matias, AU - Ruiz,Ana Lúcia Tasca Gois, AU - de Carvalho,João Ernesto, AU - Ikegaki,Masaharu, Y1 - 2019/05/21/ PY - 2019/5/22/entrez PY - 2019/5/22/pubmed PY - 2019/5/22/medline KW - Geopropolis KW - LC-ESI-QTOF-MS KW - Melipona KW - antimicrobial KW - antioxidant KW - synergistic effect SP - 1 EP - 6 JF - Natural product research JO - Nat. Prod. Res. N2 - The geopropolis is a unique type of propolis produced by some stingless bee species. This product is known in folk medicine for its pharmacological properties, mainly antimicrobial and antioxidant, but there are few scientific studies that prove these properties. The objective of this study was to evaluate the phenolic composition and the antimicrobial, antioxidant and antiproliferative activities of Melipona quadrifasciata geopropolis. The phenolic characterization of the geopropolis ethanolic extract was evaluated by LC-ESI-QTOF-MS. The antimicrobial activity was carried out against Gram-positive (including multiresistant microorganisms), negative and yeast. The synergistic effect was evaluated in association with Sulfamethoxazole + Trimethoprim. DPPH, ABTS, FRAP, ORAC and HPLC on-line were used to evaluate the antioxidant activity. Antiproliferative activity was assessed by the sulforhodamine B assay. Flavonoids and phenolic acids were identified in the extract, which showed promising antimicrobial activity, partially synergistic effect and antioxidant activity. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/31112035/A_comprehensive_characterization_of_polyphenols_by_LC_ESI_QTOF_MS_from_Melipona_quadrifasciata_anthidioides_geopropolis_and_their_antibacterial_antioxidant_and_antiproliferative_effects_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2019.1607851 DB - PRIME DP - Unbound Medicine ER -
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