Tags

Type your tag names separated by a space and hit enter

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil.

Abstract

BACKGROUND

Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation.

OBJECTIVE

The aim of this study was to evaluate which variants of HLA-B are associated with the risk of HIV vertical transmission in infected pregnant women and in their offspring, in a referral center in Salvador Bahia.

METHODS

We performed HLA-B genotyping in 52 HIV-infected mothers and their children exposed to HIV-1 during pregnancy (N=65) in Salvador, Brazil. We compared the HLA-B alleles frequency in mothers, uninfected and infected children, according to the use of antiretroviral prophylaxis.

RESULTS

Absence of antiretroviral antenatal and postnatal prophylaxis was significantly associated with vertical transmission of HIV-1 (p=<0.01, and p=<0.01 respectively). Frequency of HLA-B*14 (29.2%, p=0.002), HLA-B*18 (16.7%, p=0.04) or HLA-B*14:1 (20.8%, p=0.01) alleles subgroups were significantly higher in HIV-1 infected children and persisted (HLA-B*14, p=0.04) even after adjusting for use of antiretroviral prophylaxis. No significant difference in expression of HLA-B alleles was observed among mothers who transmitted the virus compared to those who did not.

CONCLUSIONS

Expression of HLA-B*14 allele in children exposed to HIV-1 is predictive of vertical transmission and reinforces the important role of genetics in mother-to-child transmission.

Links

  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Escola de Medicina Salvador, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.

    ,

    Universidade Federal da Bahia, Escola de Medicina Salvador, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.

    ,

    Universidade Federal da Bahia, Escola de Medicina Salvador, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil.

    ,

    Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil.

    Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil. Electronic address: crbrites@gmail.com.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31112676

    Citation

    Angulo, Juan Manuel Cubillos, et al. "HLA-B*14 Allele Predicts HIV-1 Mother-to-child-transmission, in Salvador, Brazil." The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases, vol. 23, no. 2, 2019, pp. 71-78.
    Angulo JMC, Cuesta TAC, Menezes EP, et al. HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil. Braz J Infect Dis. 2019;23(2):71-78.
    Angulo, J. M. C., Cuesta, T. A. C., Menezes, E. P., Pedroso, C., & Brites, C. (2019). HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil. The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases, 23(2), pp. 71-78. doi:10.1016/j.bjid.2019.04.009.
    Angulo JMC, et al. HLA-B*14 Allele Predicts HIV-1 Mother-to-child-transmission, in Salvador, Brazil. Braz J Infect Dis. 2019;23(2):71-78. PubMed PMID: 31112676.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil. AU - Angulo,Juan Manuel Cubillos, AU - Cuesta,Taryn Ariadna Castro, AU - Menezes,Eliane Pereira, AU - Pedroso,Celia, AU - Brites,Carlos, Y1 - 2019/05/18/ PY - 2018/12/11/received PY - 2019/04/22/revised PY - 2019/04/25/accepted PY - 2019/5/22/pubmed PY - 2019/5/22/medline PY - 2019/5/22/entrez KW - HIV KW - HLA-B KW - Mother to child transmission SP - 71 EP - 78 JF - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases JO - Braz J Infect Dis VL - 23 IS - 2 N2 - BACKGROUND: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation. OBJECTIVE: The aim of this study was to evaluate which variants of HLA-B are associated with the risk of HIV vertical transmission in infected pregnant women and in their offspring, in a referral center in Salvador Bahia. METHODS: We performed HLA-B genotyping in 52 HIV-infected mothers and their children exposed to HIV-1 during pregnancy (N=65) in Salvador, Brazil. We compared the HLA-B alleles frequency in mothers, uninfected and infected children, according to the use of antiretroviral prophylaxis. RESULTS: Absence of antiretroviral antenatal and postnatal prophylaxis was significantly associated with vertical transmission of HIV-1 (p=<0.01, and p=<0.01 respectively). Frequency of HLA-B*14 (29.2%, p=0.002), HLA-B*18 (16.7%, p=0.04) or HLA-B*14:1 (20.8%, p=0.01) alleles subgroups were significantly higher in HIV-1 infected children and persisted (HLA-B*14, p=0.04) even after adjusting for use of antiretroviral prophylaxis. No significant difference in expression of HLA-B alleles was observed among mothers who transmitted the virus compared to those who did not. CONCLUSIONS: Expression of HLA-B*14 allele in children exposed to HIV-1 is predictive of vertical transmission and reinforces the important role of genetics in mother-to-child transmission. SN - 1678-4391 UR - https://www.unboundmedicine.com/medline/citation/31112676/HLA-B*14_allele_predicts_HIV-1_mother-to-child-transmission,_in_Salvador,_Brazil L2 - https://linkinghub.elsevier.com/retrieve/pii/S1413-8670(18)31091-2 DB - PRIME DP - Unbound Medicine ER -