Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation by the Single-Step Co-Jet Milling.
J Pharm Sci. 2019 09; 108(9):3146-3151.JP

Abstract

Homogeneous mixing of 2 cohesive jet-milled drug powders is a challenge for pharmaceutical manufacturing on account of their cohesive nature resulting in the formation of strong and random agglomerates. In this study, colistin and ciprofloxacin were co-jet milled to develop combinational antibiotic dry powder formulations for inhalation. The properties of particle size, morphology, content uniformity, and in vitro aerosolization were evaluated. The distribution of 2 drugs in the co-jet milled powders was assessed using time-of-flight-secondary ion mass spectrometry. The co-jet milled powders demonstrated an acceptable content uniformity indicating homogeneity. In general, time-of-flight-secondary ion mass spectrometry images showed relatively homogeneous distributions of ciprofloxacin and colistin in the co-milled formulations. Importantly, the 2 drugs generally had the similar fine particle fraction and deposition behavior in each combinational formulation supporting that the particle mixtures were relatively homogenous and could maximize the antimicrobial synergy. In conclusion, co-jet milling could be a viable technique to produce the combination powders for inhalation.

Links

PMC Free PDF

Authors+Show Affiliations

Ling J

School of Food and Pharmacy, Zhejiang Ocean University, Zhuoshan 316022, China; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907.

Mangal S

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907.

Park H

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907.

Wang S

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.

Cavallaro A

Future Industries Institute, University of South Australia, Mawson Lakes, South Australia 5095, Australia.

Zhou QT

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907. Electronic address: tonyzhou@purdue.edu.

MeSH

Administration, InhalationAerosolsAnti-Bacterial AgentsChemistry, PharmaceuticalCiprofloxacinColistinDrug CombinationsDrug CompoundingDry Powder InhalersFeasibility StudiesParticle SizePowders

Pub Type(s)

Journal Article

Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31112716

Citation

Ling, Junhong, et al. "Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation By the Single-Step Co-Jet Milling." Journal of Pharmaceutical Sciences, vol. 108, no. 9, 2019, pp. 3146-3151.

Ling J, Mangal S, Park H, et al. Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation by the Single-Step Co-Jet Milling. J Pharm Sci. 2019;108(9):3146-3151.

Ling, J., Mangal, S., Park, H., Wang, S., Cavallaro, A., & Zhou, Q. T. (2019). Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation by the Single-Step Co-Jet Milling. Journal of Pharmaceutical Sciences, 108(9), 3146-3151. https://doi.org/10.1016/j.xphs.2019.05.011

Ling J, et al. Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation By the Single-Step Co-Jet Milling. J Pharm Sci. 2019;108(9):3146-3151. PubMed PMID: 31112716.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation by the Single-Step Co-Jet Milling. AU - Ling,Junhong, AU - Mangal,Sharad, AU - Park,Heejun, AU - Wang,Shaoning, AU - Cavallaro,Alex, AU - Zhou,Qi Tony, Y1 - 2019/05/18/ PY - 2019/03/07/received PY - 2019/04/17/revised PY - 2019/05/07/accepted PY - 2019/5/22/pubmed PY - 2020/8/22/medline PY - 2019/5/22/entrez KW - aerosol performance KW - dry powder inhaler KW - jet milling KW - mixing KW - uniformity SP - 3146 EP - 3151 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 108 IS - 9 N2 - Homogeneous mixing of 2 cohesive jet-milled drug powders is a challenge for pharmaceutical manufacturing on account of their cohesive nature resulting in the formation of strong and random agglomerates. In this study, colistin and ciprofloxacin were co-jet milled to develop combinational antibiotic dry powder formulations for inhalation. The properties of particle size, morphology, content uniformity, and in vitro aerosolization were evaluated. The distribution of 2 drugs in the co-jet milled powders was assessed using time-of-flight-secondary ion mass spectrometry. The co-jet milled powders demonstrated an acceptable content uniformity indicating homogeneity. In general, time-of-flight-secondary ion mass spectrometry images showed relatively homogeneous distributions of ciprofloxacin and colistin in the co-milled formulations. Importantly, the 2 drugs generally had the similar fine particle fraction and deposition behavior in each combinational formulation supporting that the particle mixtures were relatively homogenous and could maximize the antimicrobial synergy. In conclusion, co-jet milling could be a viable technique to produce the combination powders for inhalation. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/31112716/Simultaneous_Particle_Size_Reduction_and_Homogeneous_Mixing_to_Produce_Combinational_Powder_Formulations_for_Inhalation_by_the_Single_Step_Co_Jet_Milling_ DB - PRIME DP - Unbound Medicine ER -

Tags

Simultaneous Particle Size Reduction and Homogeneous Mixing to Produce Combinational Powder Formulations for Inhalation by the Single-Step Co-Jet Milling.J Pharm Sci. 2019 09; 108(9):3146-3151.JP