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Facilitated transfer of glucose from blood into perilymph in the rat cochlea.
Am J Physiol. 1987 Jul; 253(1 Pt 2):F59-65.AJ

Abstract

The transport of glucose into cochlear endolymph, perilymph of scala vestibuli and perilymph of scala tympani, and cerebrospinal fluid (CSF) was studied after intravenous administration of tracers of D-glucose, L-glucose, and 3-O-methyl-D-glucose in anesthetized rats. The data showed that D-glucose concentrations in perilymph of scala vestibuli, perilymph of scala tympani, and CSF were approximately 50%, and in endolymph less than 10%, that in plasma; D-glucose concentration in perilymph of scala vestibuli, perilymph of scala tympani, and CSF increased as a linear function of that in plasma; D-glucose entry into perilymph of scala vestibuli, perilymph of scala tympani, and CSF was more rapid than that of L-glucose; after infusion of 3-O-methyl-D-glucose, but not after that of mannitol, both the D-glucose concentration ratio of perilymph over plasma and D-glucose transfer into perilymph were lowered. These results indicate that D-glucose enters into perilymph of scala vestibuli by a facilitated transport, possibly located at the blood-perilymph barrier.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3111276

Citation

Ferrary, E, et al. "Facilitated Transfer of Glucose From Blood Into Perilymph in the Rat Cochlea." The American Journal of Physiology, vol. 253, no. 1 Pt 2, 1987, pp. F59-65.
Ferrary E, Sterkers O, Saumon G, et al. Facilitated transfer of glucose from blood into perilymph in the rat cochlea. Am J Physiol. 1987;253(1 Pt 2):F59-65.
Ferrary, E., Sterkers, O., Saumon, G., Tran Ba Huy, P., & Amiel, C. (1987). Facilitated transfer of glucose from blood into perilymph in the rat cochlea. The American Journal of Physiology, 253(1 Pt 2), F59-65.
Ferrary E, et al. Facilitated Transfer of Glucose From Blood Into Perilymph in the Rat Cochlea. Am J Physiol. 1987;253(1 Pt 2):F59-65. PubMed PMID: 3111276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Facilitated transfer of glucose from blood into perilymph in the rat cochlea. AU - Ferrary,E, AU - Sterkers,O, AU - Saumon,G, AU - Tran Ba Huy,P, AU - Amiel,C, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - F59 EP - 65 JF - The American journal of physiology JO - Am J Physiol VL - 253 IS - 1 Pt 2 N2 - The transport of glucose into cochlear endolymph, perilymph of scala vestibuli and perilymph of scala tympani, and cerebrospinal fluid (CSF) was studied after intravenous administration of tracers of D-glucose, L-glucose, and 3-O-methyl-D-glucose in anesthetized rats. The data showed that D-glucose concentrations in perilymph of scala vestibuli, perilymph of scala tympani, and CSF were approximately 50%, and in endolymph less than 10%, that in plasma; D-glucose concentration in perilymph of scala vestibuli, perilymph of scala tympani, and CSF increased as a linear function of that in plasma; D-glucose entry into perilymph of scala vestibuli, perilymph of scala tympani, and CSF was more rapid than that of L-glucose; after infusion of 3-O-methyl-D-glucose, but not after that of mannitol, both the D-glucose concentration ratio of perilymph over plasma and D-glucose transfer into perilymph were lowered. These results indicate that D-glucose enters into perilymph of scala vestibuli by a facilitated transport, possibly located at the blood-perilymph barrier. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/3111276/Facilitated_transfer_of_glucose_from_blood_into_perilymph_in_the_rat_cochlea_ L2 - https://journals.physiology.org/doi/10.1152/ajprenal.1987.253.1.F59?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -