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Small RNAs to treat human immunodeficiency virus type 1 infection by gene therapy.
Curr Opin Virol 2019; 38:10-20CO

Abstract

Current drug therapies for human immunodeficiency virus type 1 (HIV) infection are effective in preventing progression to acquired immune deficiency syndrome but do not eliminate the infection and are associated with unwanted side effects. A potential alternative is to modify the genome of patient cells via gene therapy to confer HIV resistance to these cells. Small RNAs are the largest and most diverse group of anti-HIV genes that have been developed for engineering HIV resistant cells. In this review, we summarize progress on the three major classes of anti-HIV RNAs including short hairpin RNAs that use the RNA interference pathway, RNA decoys and aptamers that bind specifically to a protein or RNA as well as ribozymes that mediate cleavage of specific targets. We also review methods used for the delivery of these genes into the genome of patient cells and provide some perspectives on the future of small RNAs in HIV therapy.

Authors+Show Affiliations

Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada; Department of Microbiology and Immunology, McGill University, Montréal, Québec H3A 0G4, Canada.Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada; Department of Microbiology and Immunology, McGill University, Montréal, Québec H3A 0G4, Canada.Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada; Department of Microbiology and Immunology, McGill University, Montréal, Québec H3A 0G4, Canada. Electronic address: robert.scarborough@mail.mcgill.ca.Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada; Department of Microbiology and Immunology, McGill University, Montréal, Québec H3A 0G4, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec H3A 0G4, Canada. Electronic address: anne.gatignol@mcgill.ca.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31112858

Citation

Goguen, Ryan P., et al. "Small RNAs to Treat Human Immunodeficiency Virus Type 1 Infection By Gene Therapy." Current Opinion in Virology, vol. 38, 2019, pp. 10-20.
Goguen RP, Malard CM, Scarborough RJ, et al. Small RNAs to treat human immunodeficiency virus type 1 infection by gene therapy. Curr Opin Virol. 2019;38:10-20.
Goguen, R. P., Malard, C. M., Scarborough, R. J., & Gatignol, A. (2019). Small RNAs to treat human immunodeficiency virus type 1 infection by gene therapy. Current Opinion in Virology, 38, pp. 10-20. doi:10.1016/j.coviro.2019.04.003.
Goguen RP, et al. Small RNAs to Treat Human Immunodeficiency Virus Type 1 Infection By Gene Therapy. Curr Opin Virol. 2019 May 18;38:10-20. PubMed PMID: 31112858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small RNAs to treat human immunodeficiency virus type 1 infection by gene therapy. AU - Goguen,Ryan P, AU - Malard,Camille Mg, AU - Scarborough,Robert J, AU - Gatignol,Anne, Y1 - 2019/05/18/ PY - 2019/03/11/received PY - 2019/04/10/revised PY - 2019/04/16/accepted PY - 2019/5/22/pubmed PY - 2019/5/22/medline PY - 2019/5/22/entrez SP - 10 EP - 20 JF - Current opinion in virology JO - Curr Opin Virol VL - 38 N2 - Current drug therapies for human immunodeficiency virus type 1 (HIV) infection are effective in preventing progression to acquired immune deficiency syndrome but do not eliminate the infection and are associated with unwanted side effects. A potential alternative is to modify the genome of patient cells via gene therapy to confer HIV resistance to these cells. Small RNAs are the largest and most diverse group of anti-HIV genes that have been developed for engineering HIV resistant cells. In this review, we summarize progress on the three major classes of anti-HIV RNAs including short hairpin RNAs that use the RNA interference pathway, RNA decoys and aptamers that bind specifically to a protein or RNA as well as ribozymes that mediate cleavage of specific targets. We also review methods used for the delivery of these genes into the genome of patient cells and provide some perspectives on the future of small RNAs in HIV therapy. SN - 1879-6265 UR - https://www.unboundmedicine.com/medline/citation/31112858/Small_RNAs_to_treat_human_immunodeficiency_virus_type_1_infection_by_gene_therapy L2 - https://linkinghub.elsevier.com/retrieve/pii/S1879-6257(19)30006-9 DB - PRIME DP - Unbound Medicine ER -