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Gaseous transmitters in human retinogenesis.
Acta Histochem. 2019 Jul; 121(5):604-610.AH

Abstract

Endogenous gaseous transmitters (nitric oxide, carbon monoxide, and hydrogen sulphide) form a special neuromodulation system mediating the development and modification of nerve centers. Here, we examined the localization of key gaseous transmitter enzymes: cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE), heme oxygenase 2 (HO-2), and constitutive NO synthase (nNOS) in the fetal human retina at different stages of development. The number of CBS- and CSE-positive photoreceptors and intermediate retinal neurons was high in trimester I and gradually decreased to the end of trimester III. The number of HO-2-positive cells followed the same trend. The number of nNOS-positive intermediate retinal neurons and neurons within the ganglion cell layer showed the opposite dynamics with the peak in trimester III. The results are interpreted in terms of the role of gaseous transmitters in retinogenesis and cytoprotection.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Kalinichenko SG
Department of Histology, Cytology and Embryology, Pacific State Medical University, Vladivostok 690950, Russia.
Matveeva NY
Department of Histology, Cytology and Embryology, Pacific State Medical University, Vladivostok 690950, Russia.
Pushchin II
Laboratory of Physiology, Institute of Marine Biology, A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia. Electronic address: ipushchin@gmail.com.

MeSH

Carbon MonoxideCystathionine beta-SynthaseCystathionine gamma-LyaseEmbryonic DevelopmentGasotransmittersHeme Oxygenase (Decyclizing)HumansHydrogen SulfideImmunohistochemistryNitric OxideNitric Oxide SynthaseRetina

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31113654

Citation

Kalinichenko, Sergei G., et al. "Gaseous Transmitters in Human Retinogenesis." Acta Histochemica, vol. 121, no. 5, 2019, pp. 604-610.
Kalinichenko SG, Matveeva NY, Pushchin II. Gaseous transmitters in human retinogenesis. Acta Histochem. 2019;121(5):604-610.
Kalinichenko, S. G., Matveeva, N. Y., & Pushchin, I. I. (2019). Gaseous transmitters in human retinogenesis. Acta Histochemica, 121(5), 604-610. https://doi.org/10.1016/j.acthis.2019.05.003
Kalinichenko SG, Matveeva NY, Pushchin II. Gaseous Transmitters in Human Retinogenesis. Acta Histochem. 2019;121(5):604-610. PubMed PMID: 31113654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gaseous transmitters in human retinogenesis. AU - Kalinichenko,Sergei G, AU - Matveeva,Natalya Yu, AU - Pushchin,Igor I, Y1 - 2019/05/18/ PY - 2019/02/04/received PY - 2019/05/08/revised PY - 2019/05/10/accepted PY - 2019/5/23/pubmed PY - 2019/10/24/medline PY - 2019/5/23/entrez KW - Constitutive NO synthase KW - Cystathionine β-synthetase KW - Cystathionine γ-lyase KW - Gaseous transmitters KW - Heme oxygenase 2 KW - Neurogenesis SP - 604 EP - 610 JF - Acta histochemica JO - Acta Histochem VL - 121 IS - 5 N2 - Endogenous gaseous transmitters (nitric oxide, carbon monoxide, and hydrogen sulphide) form a special neuromodulation system mediating the development and modification of nerve centers. Here, we examined the localization of key gaseous transmitter enzymes: cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE), heme oxygenase 2 (HO-2), and constitutive NO synthase (nNOS) in the fetal human retina at different stages of development. The number of CBS- and CSE-positive photoreceptors and intermediate retinal neurons was high in trimester I and gradually decreased to the end of trimester III. The number of HO-2-positive cells followed the same trend. The number of nNOS-positive intermediate retinal neurons and neurons within the ganglion cell layer showed the opposite dynamics with the peak in trimester III. The results are interpreted in terms of the role of gaseous transmitters in retinogenesis and cytoprotection. SN - 1618-0372 UR - https://www.unboundmedicine.com/medline/citation/31113654/Gaseous_transmitters_in_human_retinogenesis_ DB - PRIME DP - Unbound Medicine ER -