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Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes.

Abstract

Purpose:

Abnormal levels of lipid accumulation product (LAP) have been associated with risk of cardiovascular disease and diabetes. However, it is not clear whether LAP index is associated with diabetic retinopathy (DR). We investigated the association between LAP index and DR in Chinese adults with diabetes. Patients and methods: We included 427 Chinese patients with type 2 diabetes aged 18-year over who participated in a community-based cross-sectional study in Shenyang. DR was addressed on retinal photographs graded using the modified Airlie House classification. LAP was defined as (waist circumference [cm]-65) × (triglycerides [mmol/L]) in men, and (waist circumference [cm]-58) × (triglycerides [mmol/L]) in women and analyzed continuously (per SD change) and categorically (quartile 1, <30; quartile 2, 30-50; and quartile 3, >50).

Results:

Prevalence of DR among the study population was 17.8%. The mean level of LAP was 52.96±44.01. Compared to quartile 1 level, both quartile 2 and 3 levels were associated with DR with multivariable odds ratio (95% CI) of 0.23 (0.12-0.46) and 0.27 (0.14-0.54), respectively. These associations persisted when LAP was analyzed continuously (0.57 [0.35-0.92]).

Conclusion:

Higher central lipid accumulation in Chinese diabetics is related to the lower risk of DR, suggesting that LAP may be useful for identifying type 2 diabetes mellitus patients who are at risk for DR.

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  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

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    Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

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    Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

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    Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, People's Republic of China.

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    Department of Ophthalmology, Hohhot Chao Ju Eye Hospital, Hohhot 010000, People's Republic of China.

    ,

    Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

    Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31114279

    Citation

    Wu, Jingyang, et al. "Association Between Lipid Accumulation Product and Diabetic Retinopathy Based On a Community-based Survey in Chinese With Type 2 Diabetes." Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, vol. 12, 2019, pp. 513-518.
    Wu J, Zhong Y, Yue S, et al. Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes. Diabetes Metab Syndr Obes. 2019;12:513-518.
    Wu, J., Zhong, Y., Yue, S., Guan, P., Zhang, G., Liu, L., & Chen, L. (2019). Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 12, pp. 513-518. doi:10.2147/DMSO.S195578.
    Wu J, et al. Association Between Lipid Accumulation Product and Diabetic Retinopathy Based On a Community-based Survey in Chinese With Type 2 Diabetes. Diabetes Metab Syndr Obes. 2019;12:513-518. PubMed PMID: 31114279.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between lipid accumulation product and diabetic retinopathy based on a community-based survey in Chinese with type 2 diabetes. AU - Wu,Jingyang, AU - Zhong,Yifan, AU - Yue,Song, AU - Guan,Peng, AU - Zhang,Guisen, AU - Liu,Lei, AU - Chen,Lei, Y1 - 2019/04/16/ PY - 2018/11/22/received PY - 2019/02/19/accepted PY - 2019/5/23/entrez PY - 2019/5/23/pubmed PY - 2019/5/23/medline KW - diabetes KW - diabetic retinopathy KW - lipid accumulation product SP - 513 EP - 518 JF - Diabetes, metabolic syndrome and obesity : targets and therapy JO - Diabetes Metab Syndr Obes VL - 12 N2 - Purpose: Abnormal levels of lipid accumulation product (LAP) have been associated with risk of cardiovascular disease and diabetes. However, it is not clear whether LAP index is associated with diabetic retinopathy (DR). We investigated the association between LAP index and DR in Chinese adults with diabetes. Patients and methods: We included 427 Chinese patients with type 2 diabetes aged 18-year over who participated in a community-based cross-sectional study in Shenyang. DR was addressed on retinal photographs graded using the modified Airlie House classification. LAP was defined as (waist circumference [cm]-65) × (triglycerides [mmol/L]) in men, and (waist circumference [cm]-58) × (triglycerides [mmol/L]) in women and analyzed continuously (per SD change) and categorically (quartile 1, <30; quartile 2, 30-50; and quartile 3, >50). Results: Prevalence of DR among the study population was 17.8%. The mean level of LAP was 52.96±44.01. Compared to quartile 1 level, both quartile 2 and 3 levels were associated with DR with multivariable odds ratio (95% CI) of 0.23 (0.12-0.46) and 0.27 (0.14-0.54), respectively. These associations persisted when LAP was analyzed continuously (0.57 [0.35-0.92]). Conclusion: Higher central lipid accumulation in Chinese diabetics is related to the lower risk of DR, suggesting that LAP may be useful for identifying type 2 diabetes mellitus patients who are at risk for DR. SN - 1178-7007 UR - https://www.unboundmedicine.com/medline/citation/31114279/Association_between_lipid_accumulation_product_and_diabetic_retinopathy_based_on_a_community-based_survey_in_Chinese_with_type_2_diabetes L2 - https://dx.doi.org/10.2147/DMSO.S195578 DB - PRIME DP - Unbound Medicine ER -