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Germline genetics in localized prostate cancer.

Abstract

PURPOSE OF REVIEW

To provide the reader an understanding of the importance and limitations of prostate cancer (PCa) screening, the heritable component of PCa and the role that germline genetic markers can play in risk-adapted screening and treatment.

RECENT FINDINGS

Despite strong science supporting the association of germline genetic change with PCa risk and outcome, there has been a reluctance to pursue practical application of these technologies. Recent findings suggest that actionable information may now be garnered from this form of testing, which can help men at risk for and with PCa.

SUMMARY

This is an exciting time whereby germline genetic markers can help overcome some of the shortcomings of current PCa screening and treatment paradigms. Understanding their benefit and limitations while keeping the patient's best interest in mind will be the key for the responsible application of these exciting technologies.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Urology, University of California San Diego, La Jolla, California, USA.

    , , ,

    Source

    Current opinion in urology 29:4 2019 Jul pg 326-333

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31116139

    Citation

    Ryan, Stephen T., et al. "Germline Genetics in Localized Prostate Cancer." Current Opinion in Urology, vol. 29, no. 4, 2019, pp. 326-333.
    Ryan ST, Nguyen V, Bree KK, et al. Germline genetics in localized prostate cancer. Curr Opin Urol. 2019;29(4):326-333.
    Ryan, S. T., Nguyen, V., Bree, K. K., Holst, D. D., & Kader, A. K. (2019). Germline genetics in localized prostate cancer. Current Opinion in Urology, 29(4), pp. 326-333. doi:10.1097/MOU.0000000000000648.
    Ryan ST, et al. Germline Genetics in Localized Prostate Cancer. Curr Opin Urol. 2019;29(4):326-333. PubMed PMID: 31116139.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Germline genetics in localized prostate cancer. AU - Ryan,Stephen T, AU - Nguyen,Vi, AU - Bree,Kelly K, AU - Holst,Daniel D, AU - Kader,A Karim, PY - 2019/5/23/pubmed PY - 2019/5/23/medline PY - 2019/5/23/entrez SP - 326 EP - 333 JF - Current opinion in urology JO - Curr Opin Urol VL - 29 IS - 4 N2 - PURPOSE OF REVIEW: To provide the reader an understanding of the importance and limitations of prostate cancer (PCa) screening, the heritable component of PCa and the role that germline genetic markers can play in risk-adapted screening and treatment. RECENT FINDINGS: Despite strong science supporting the association of germline genetic change with PCa risk and outcome, there has been a reluctance to pursue practical application of these technologies. Recent findings suggest that actionable information may now be garnered from this form of testing, which can help men at risk for and with PCa. SUMMARY: This is an exciting time whereby germline genetic markers can help overcome some of the shortcomings of current PCa screening and treatment paradigms. Understanding their benefit and limitations while keeping the patient's best interest in mind will be the key for the responsible application of these exciting technologies. SN - 1473-6586 UR - https://www.unboundmedicine.com/medline/citation/31116139/Germline_genetics_in_localized_prostate_cancer L2 - http://Insights.ovid.com/pubmed?pmid=31116139 DB - PRIME DP - Unbound Medicine ER -