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Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma.
Clin Transl Gastroenterol 2019; 10(5):1-7CT

Abstract

INTRODUCTION

Prostate-specific membrane antigen (PSMA) was originally found to be specifically expressed in normal prostate, and its expression was upregulated in almost all stages of prostate cancer. In recent years, PSMA was also found to be expressed in tumor-associated vasculature in many nonprostatic solid tumors. However, the expression pattern of PSMA in hepatocellular carcinoma (HCC) is not well studied.

METHODS

In this study, we examined PSMA expression in 103 HCC tissues using immunohistochemical staining and analyzed the association between PSMA expression and other clinicopathological features and prognosis.

RESULTS

Among the 103 cases, 27 cases (26%) showed PSMA expression in more than 50% of tumor-associated vasculature, 49 cases (48%) showed PSMA expression in less than 50% of vasculature, and 27 cases (26%) did not have detectable PSMA expression. Vascular PSMA expression was associated with several clinicopathological features, such as tumor stage, tumor differentiation, lymph node metastasis, and Ki-67 index. Furthermore, high vascular PSMA expression was also associated with poor prognosis in patients with HCC. Univariate and multivariate analyses showed that high vascular PSMA expression can be used as an independent prognostic marker for HCC.

DISCUSSION

Our study provides the evidence that PSMA is specifically expressed in tumor-associated vasculature of HCC, and vascular PSMA expression may be used as a novel prognostic marker and a vascular therapeutic target for HCC.

Authors+Show Affiliations

Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China.Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.Department of Urology, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China.State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China.OriMAbs Ltd, Newark, Delaware, USA.OriMAbs Ltd, Newark, Delaware, USA.State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China.Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.State Key Laboratory of Cancer Biology, Department of Immunology, Fourth Military Medical University, Xi'an, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31116141

Citation

Jiao, Dian, et al. "Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma." Clinical and Translational Gastroenterology, vol. 10, no. 5, 2019, pp. 1-7.
Jiao D, Li Y, Yang F, et al. Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma. Clin Transl Gastroenterol. 2019;10(5):1-7.
Jiao, D., Li, Y., Yang, F., Han, D., Wu, J., Shi, S., ... Wen, W. (2019). Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma. Clinical and Translational Gastroenterology, 10(5), pp. 1-7. doi:10.14309/ctg.0000000000000041.
Jiao D, et al. Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma. Clin Transl Gastroenterol. 2019 May 22;10(5):1-7. PubMed PMID: 31116141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma. AU - Jiao,Dian, AU - Li,Yu, AU - Yang,Fa, AU - Han,Donghui, AU - Wu,Jieheng, AU - Shi,Shengjia, AU - Tian,Feng, AU - Guo,Zhangyan, AU - Xi,Wenjin, AU - Li,Guodong, AU - Zhao,Aizhi, AU - Yang,An-Gang, AU - Qin,Weijun, AU - Wang,He, AU - Wen,Weihong, PY - 2019/5/23/entrez PY - 2019/5/23/pubmed PY - 2019/5/23/medline SP - 1 EP - 7 JF - Clinical and translational gastroenterology JO - Clin Transl Gastroenterol VL - 10 IS - 5 N2 - INTRODUCTION: Prostate-specific membrane antigen (PSMA) was originally found to be specifically expressed in normal prostate, and its expression was upregulated in almost all stages of prostate cancer. In recent years, PSMA was also found to be expressed in tumor-associated vasculature in many nonprostatic solid tumors. However, the expression pattern of PSMA in hepatocellular carcinoma (HCC) is not well studied. METHODS: In this study, we examined PSMA expression in 103 HCC tissues using immunohistochemical staining and analyzed the association between PSMA expression and other clinicopathological features and prognosis. RESULTS: Among the 103 cases, 27 cases (26%) showed PSMA expression in more than 50% of tumor-associated vasculature, 49 cases (48%) showed PSMA expression in less than 50% of vasculature, and 27 cases (26%) did not have detectable PSMA expression. Vascular PSMA expression was associated with several clinicopathological features, such as tumor stage, tumor differentiation, lymph node metastasis, and Ki-67 index. Furthermore, high vascular PSMA expression was also associated with poor prognosis in patients with HCC. Univariate and multivariate analyses showed that high vascular PSMA expression can be used as an independent prognostic marker for HCC. DISCUSSION: Our study provides the evidence that PSMA is specifically expressed in tumor-associated vasculature of HCC, and vascular PSMA expression may be used as a novel prognostic marker and a vascular therapeutic target for HCC. SN - 2155-384X UR - https://www.unboundmedicine.com/medline/citation/31116141/Expression_of_Prostate-Specific_Membrane_Antigen_in_Tumor-Associated_Vasculature_Predicts_Poor_Prognosis_in_Hepatocellular_Carcinoma L2 - http://dx.doi.org/10.14309/ctg.0000000000000041 DB - PRIME DP - Unbound Medicine ER -