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CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats.
Neurosci Lett. 2019 07 27; 706:189-193.NL

Abstract

In this study, we have pursued to assess oleamide's potential role in reward and aversion mechanisms. To reach this goal we infused oleamide, either 1 μg into the nucleus accumbens shell (NAccS) and evaluated its effects on conditioned place preference (CCP) or 10 μg, to evaluate conditioned place aversion (CPA). Extinction and reinstatement were also evaluated in both cases. We sought to determine if CPP occurs via cannabinoid receptor 1 (CB1R) and CPA via serontoninergic 2c receptor (5HT2cR). Results revealed that 1 μg of oleamide administered bilaterally into the NAccS induced CPP, while 10 μg induced CPA. In both conditions CPP or CPA, reinstatement after extinction was induced. AM251 (CB1R inverse-agonist) prevented CPP induced with 1 μg; while SB242084 (5HT2cR antagonist) not only prevented CPA induced with 10 μg but caused a switch to CPP. These results suggest that oleamide at low doses promotes reward through CB1R, and aversion at high doses via 5HT2cR.

Authors+Show Affiliations

Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.Grupo de Neurociencias, Laboratorio de Neurogenómica Cognitiva, Coordinación de Psicobiología y Neurociencias, Facultad de Psicología. Universidad Nacional Autónoma de México, Mexico.Grupo de Neurociencias, Laboratorio de Canabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico. Electronic address: opg@unam.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31116971

Citation

Méndez-Díaz, Mónica, et al. "CB1R Mediates Oleamide's Reward While 5HT2cR Mediates Aversion in the Nucleus Accumbens Shell of Rats." Neuroscience Letters, vol. 706, 2019, pp. 189-193.
Méndez-Díaz M, Amancio-Belmont O, Estrada-González V, et al. CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats. Neurosci Lett. 2019;706:189-193.
Méndez-Díaz, M., Amancio-Belmont, O., Estrada-González, V., Ruiz-Contreras, A. E., & Prospéro-García, O. (2019). CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats. Neuroscience Letters, 706, 189-193. https://doi.org/10.1016/j.neulet.2019.05.033
Méndez-Díaz M, et al. CB1R Mediates Oleamide's Reward While 5HT2cR Mediates Aversion in the Nucleus Accumbens Shell of Rats. Neurosci Lett. 2019 07 27;706:189-193. PubMed PMID: 31116971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats. AU - Méndez-Díaz,Mónica, AU - Amancio-Belmont,Octavio, AU - Estrada-González,Vicente, AU - Ruiz-Contreras,Alejandra E, AU - Prospéro-García,Oscar, Y1 - 2019/05/19/ PY - 2019/02/26/received PY - 2019/05/16/revised PY - 2019/05/17/accepted PY - 2019/5/23/pubmed PY - 2019/12/28/medline PY - 2019/5/23/entrez KW - 5HT2c receptor KW - CB1 receptor KW - Conditioned place preference KW - Nucleus accumbens shell KW - Oleamide KW - Reward SP - 189 EP - 193 JF - Neuroscience letters JO - Neurosci Lett VL - 706 N2 - In this study, we have pursued to assess oleamide's potential role in reward and aversion mechanisms. To reach this goal we infused oleamide, either 1 μg into the nucleus accumbens shell (NAccS) and evaluated its effects on conditioned place preference (CCP) or 10 μg, to evaluate conditioned place aversion (CPA). Extinction and reinstatement were also evaluated in both cases. We sought to determine if CPP occurs via cannabinoid receptor 1 (CB1R) and CPA via serontoninergic 2c receptor (5HT2cR). Results revealed that 1 μg of oleamide administered bilaterally into the NAccS induced CPP, while 10 μg induced CPA. In both conditions CPP or CPA, reinstatement after extinction was induced. AM251 (CB1R inverse-agonist) prevented CPP induced with 1 μg; while SB242084 (5HT2cR antagonist) not only prevented CPA induced with 10 μg but caused a switch to CPP. These results suggest that oleamide at low doses promotes reward through CB1R, and aversion at high doses via 5HT2cR. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/31116971/CB1R_mediates_oleamide's_reward_while_5HT2cR_mediates_aversion_in_the_nucleus_accumbens_shell_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(19)30351-9 DB - PRIME DP - Unbound Medicine ER -