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Two years of intrauterine contraception with levonorgestrel and with copper: a randomized comparison of the TCu 380Ag and levonorgestrel 20 mcg/day devices.
Contraception. 1987 Mar; 35(3):245-55.C

Abstract

IUDs releasing 20 mcg/day of levonorgestrel (LNg20) were in randomized trial together with the Copper T, model TCu 380Ag, in seven centers involving 2244 women. Two-year (25 months) gross cumulative pregnancy rates were 0.2 +/- 0.2 and 0.9 +/- 0.3 for the levonorgestrel and copper releasing devices, respectively (P greater than 0.05). There were no ectopic pregnancies in more than 1600 woman-years of use of each device. Removal rates for bleeding and/or pain or for medical reasons other than menstrual problems did not differ significantly between devices. Oligomenorrhea or amenorrhea prompted 10.7 per hundred (gross rate, 8.4 net rate) women using the LNg 20 IUD to request removal in the two-year period, significantly above the 0.2 per hundred rate among women with the Copper IUD (P less than 0.001). At the end of two years an estimated 59.4 per 100 women were continuing use of the LNg 20 IUD, and 67.5 per 100 (P less than 0.001) with the TCu 380Ag. This difference is almost wholly ascribable to a marked reduction in bleeding episodes and days among women using the LNg 20 device with concomitant removal of device. Hemoglobin rose an average of 0.5 g/dl (P less than 0.001) for this group whereas women using the TCu 380Ag experienced a decline of 0.2 g/dl compared with baseline values (P less than 0.001).

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

3111785

Citation

Sivin, I, et al. "Two Years of Intrauterine Contraception With Levonorgestrel and With Copper: a Randomized Comparison of the TCu 380Ag and Levonorgestrel 20 Mcg/day Devices." Contraception, vol. 35, no. 3, 1987, pp. 245-55.
Sivin I, Stern J, Diaz J, et al. Two years of intrauterine contraception with levonorgestrel and with copper: a randomized comparison of the TCu 380Ag and levonorgestrel 20 mcg/day devices. Contraception. 1987;35(3):245-55.
Sivin, I., Stern, J., Diaz, J., Diaz, M. M., Faundes, A., el Mahgoub, S., Diaz, S., Pavez, M., Coutinho, E., & Mattos, C. E. (1987). Two years of intrauterine contraception with levonorgestrel and with copper: a randomized comparison of the TCu 380Ag and levonorgestrel 20 mcg/day devices. Contraception, 35(3), 245-55.
Sivin I, et al. Two Years of Intrauterine Contraception With Levonorgestrel and With Copper: a Randomized Comparison of the TCu 380Ag and Levonorgestrel 20 Mcg/day Devices. Contraception. 1987;35(3):245-55. PubMed PMID: 3111785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two years of intrauterine contraception with levonorgestrel and with copper: a randomized comparison of the TCu 380Ag and levonorgestrel 20 mcg/day devices. A1 - Sivin,I, AU - Stern,J, AU - Diaz,J, AU - Diaz,M M, AU - Faundes,A, AU - el Mahgoub,S, AU - Diaz,S, AU - Pavez,M, AU - Coutinho,E, AU - Mattos,C E, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez KW - Africa KW - Americas KW - Arab Countries KW - Asia KW - Biology KW - Brazil KW - Caribbean KW - Chile KW - Comparative Studies KW - Contraception KW - Contraception Continuation KW - Contraception Failure KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Contraceptive Usage KW - Developed Countries KW - Developing Countries KW - Diseases KW - Dominican Republic KW - Egypt KW - Endocrine System KW - Family Planning KW - Genital Effects, Female KW - Genitalia KW - Genitalia, Female KW - Hemic System KW - Hemoglobin Level KW - Hormones KW - Iud KW - Iud, Copper Releasing KW - Latin America KW - Levonorgestrel KW - Mediterranean Countries KW - Menstruation Disorders KW - North America KW - Northern Africa KW - Northern America KW - Physiology KW - Pregnancy Complications KW - Pregnancy, Ectopic KW - Reproductive Control Agents KW - Research Methodology KW - Singapore KW - South America KW - Southeastern Asia KW - Studies KW - United States KW - Urogenital Effects KW - Urogenital System SP - 245 EP - 55 JF - Contraception JO - Contraception VL - 35 IS - 3 N2 - IUDs releasing 20 mcg/day of levonorgestrel (LNg20) were in randomized trial together with the Copper T, model TCu 380Ag, in seven centers involving 2244 women. Two-year (25 months) gross cumulative pregnancy rates were 0.2 +/- 0.2 and 0.9 +/- 0.3 for the levonorgestrel and copper releasing devices, respectively (P greater than 0.05). There were no ectopic pregnancies in more than 1600 woman-years of use of each device. Removal rates for bleeding and/or pain or for medical reasons other than menstrual problems did not differ significantly between devices. Oligomenorrhea or amenorrhea prompted 10.7 per hundred (gross rate, 8.4 net rate) women using the LNg 20 IUD to request removal in the two-year period, significantly above the 0.2 per hundred rate among women with the Copper IUD (P less than 0.001). At the end of two years an estimated 59.4 per 100 women were continuing use of the LNg 20 IUD, and 67.5 per 100 (P less than 0.001) with the TCu 380Ag. This difference is almost wholly ascribable to a marked reduction in bleeding episodes and days among women using the LNg 20 device with concomitant removal of device. Hemoglobin rose an average of 0.5 g/dl (P less than 0.001) for this group whereas women using the TCu 380Ag experienced a decline of 0.2 g/dl compared with baseline values (P less than 0.001). SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/3111785/Two_years_of_intrauterine_contraception_with_levonorgestrel_and_with_copper:_a_randomized_comparison_of_the_TCu_380Ag_and_levonorgestrel_20_mcg/day_devices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(87)90026-6 DB - PRIME DP - Unbound Medicine ER -