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Immunometabolism: an overview and therapeutic prospects in autoimmune diseases.

Abstract

Metabolism is a critical immune regulator under physiologic and pathologic conditions. Culminating evidence has disentangled the contribution of distinct metabolic pathways, namely glucolysis, pentose phosphate, fatty acid oxidation, glutaminolysis, Krebs cycle and oxidative phosphorylation, in modulating innate and adaptive immune cells based on their activation/differentiation state. Metabolic aberrations and changes in the intracellular levels of specific metabolites are linked to the inflammatory phenotype of immune cells implicated in autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and diabetes. Notably, targeting metabolism such as the mTOR by rapamycin, hexokinase by 2-deoxy-D-glucose, AMP-activated protein kinase by metformin, may be used to ameliorate autoimmune inflammation. Accordingly, research in immunometabolism is expected to offer novel opportunities for monitoring and treating immune-mediated diseases.

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  • Authors+Show Affiliations

    ,

    Department of Rheumatology, Clinical Immunology & Allergy, University Hospital of Heraklion, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece. Laboratory of Rheumatology, Autoimmunity & Inflammation, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, N. Plastira 100, 70013 Heraklion, Greece.

    ,

    Department of Rheumatology, Clinical Immunology & Allergy, University Hospital of Heraklion, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece. Laboratory of Rheumatology, Autoimmunity & Inflammation, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, N. Plastira 100, 70013 Heraklion, Greece.

    Department of Rheumatology, Clinical Immunology & Allergy, University Hospital of Heraklion, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece. Laboratory of Rheumatology, Autoimmunity & Inflammation, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, N. Plastira 100, 70013 Heraklion, Greece.

    Source

    Immunotherapy 11:9 2019 Jun pg 813-829

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31120393

    Citation

    Stathopoulou, Chrysoula, et al. "Immunometabolism: an Overview and Therapeutic Prospects in Autoimmune Diseases." Immunotherapy, vol. 11, no. 9, 2019, pp. 813-829.
    Stathopoulou C, Nikoleri D, Bertsias G. Immunometabolism: an overview and therapeutic prospects in autoimmune diseases. Immunotherapy. 2019;11(9):813-829.
    Stathopoulou, C., Nikoleri, D., & Bertsias, G. (2019). Immunometabolism: an overview and therapeutic prospects in autoimmune diseases. Immunotherapy, 11(9), pp. 813-829. doi:10.2217/imt-2019-0002.
    Stathopoulou C, Nikoleri D, Bertsias G. Immunometabolism: an Overview and Therapeutic Prospects in Autoimmune Diseases. Immunotherapy. 2019;11(9):813-829. PubMed PMID: 31120393.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Immunometabolism: an overview and therapeutic prospects in autoimmune diseases. AU - Stathopoulou,Chrysoula, AU - Nikoleri,Dimitra, AU - Bertsias,George, PY - 2019/5/24/entrez KW - adaptive immunity KW - autoimmune disease KW - biomarkers KW - glycolysis KW - innate immunity KW - metabolites KW - microbiota KW - oxidative phosphorylation SP - 813 EP - 829 JF - Immunotherapy JO - Immunotherapy VL - 11 IS - 9 N2 - Metabolism is a critical immune regulator under physiologic and pathologic conditions. Culminating evidence has disentangled the contribution of distinct metabolic pathways, namely glucolysis, pentose phosphate, fatty acid oxidation, glutaminolysis, Krebs cycle and oxidative phosphorylation, in modulating innate and adaptive immune cells based on their activation/differentiation state. Metabolic aberrations and changes in the intracellular levels of specific metabolites are linked to the inflammatory phenotype of immune cells implicated in autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and diabetes. Notably, targeting metabolism such as the mTOR by rapamycin, hexokinase by 2-deoxy-D-glucose, AMP-activated protein kinase by metformin, may be used to ameliorate autoimmune inflammation. Accordingly, research in immunometabolism is expected to offer novel opportunities for monitoring and treating immune-mediated diseases. SN - 1750-7448 UR - https://www.unboundmedicine.com/medline/citation/31120393/Immunometabolism:_an_overview_and_therapeutic_prospects_in_autoimmune_diseases L2 - http://www.futuremedicine.com/doi/full/10.2217/imt-2019-0002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -