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A Modified Holder Pasteurization Method for Donor Human Milk: Preliminary Data.
Nutrients. 2019 May 22; 11(5)N

Abstract

BACKGROUND

Holder pasteurization (HoP) is the recommended method of pasteurization for donor human milk (DHM). The aim of the present study was to compare nutritional and microbiological impact on DHM of a new technique of pasteurization based on technical changes of HoP.

METHODS

We analyzed milk samples from 25 donors. Each sample, derived from one breast milk expression, was subdivided into three aliquots according to pasteurization: The first was not pasteurized, the second pasteurized by HoP, and the third was pasteurized by modified HoP (MHoP). Each aliquot was assessed as to its microbiological and nutritional profile. Nutritional profile included calcium and triglycerides concentrations detected by spectrophotometry and amino acid levels assessed by high-performance liquid chromatography (HPLC).

RESULTS

Triglycerides were significantly lower in pasteurized, by both methods, than in not pasteurized aliquots, while calcium and amino acids concentration were similar. Microbiological profile did not differ between HoP and MHoP aliquots.

CONCLUSIONS

HoP and MHoP seem to have similar efficacy in preserving some nutritional characteristics of DHM and to confer similar microbiological safety. MHoP is time-saving and potentially costs-effective when compared to HoP, and it is; therefore, potentially of more interest from a practical point of view. Further studies are needed to confirm these findings.

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Authors+Show Affiliations

Capriati T
Artificial Nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. teresa.capriati@opbg.net.
Goffredo BM
Biochemistry Laboratory, Department of Specialist Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. biancamaria.goffredo@opbg.net.
Argentieri M
Unit of Microbiology, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. marta.argentieri@opbg.net.
De Vivo L
Clinical Engineering Department, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. liliana.devivo@opbg.net.
Bernaschi P
Unit of Microbiology, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. paola.bernaschi@opbg.net.
Cairoli S
Biochemistry Laboratory, Department of Specialist Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. sara.cairoli@opbg.net.
Laureti F
Artificial Nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. francesca.laureti@opbg.net.
Reposi MP
Artificial Nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. mariapaola.reposi@opbg.net.
Marino D
Artificial Nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. daniela.marino@opbg.net.
Benedetti S
Biochemistry Laboratory, Department of Specialist Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. sabina.benedetti@opbg.net.
Diamanti A
Artificial Nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy. antonella.diamanti@opbg.net.

MeSH

Amino AcidsCalciumFemaleHumansMilk BanksMilk, HumanNutritive ValuePasteurizationPreliminary DataTissue DonorsTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31121859

Citation

Capriati, Teresa, et al. "A Modified Holder Pasteurization Method for Donor Human Milk: Preliminary Data." Nutrients, vol. 11, no. 5, 2019.
Capriati T, Goffredo BM, Argentieri M, et al. A Modified Holder Pasteurization Method for Donor Human Milk: Preliminary Data. Nutrients. 2019;11(5).
Capriati, T., Goffredo, B. M., Argentieri, M., De Vivo, L., Bernaschi, P., Cairoli, S., Laureti, F., Reposi, M. P., Marino, D., Benedetti, S., & Diamanti, A. (2019). A Modified Holder Pasteurization Method for Donor Human Milk: Preliminary Data. Nutrients, 11(5). https://doi.org/10.3390/nu11051139
Capriati T, et al. A Modified Holder Pasteurization Method for Donor Human Milk: Preliminary Data. Nutrients. 2019 May 22;11(5) PubMed PMID: 31121859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Modified Holder Pasteurization Method for Donor Human Milk: Preliminary Data. AU - Capriati,Teresa, AU - Goffredo,Bianca Maria, AU - Argentieri,Marta, AU - De Vivo,Liliana, AU - Bernaschi,Paola, AU - Cairoli,Sara, AU - Laureti,Francesca, AU - Reposi,Maria Paola, AU - Marino,Daniela, AU - Benedetti,Sabina, AU - Diamanti,Antonella, Y1 - 2019/05/22/ PY - 2019/03/31/received PY - 2019/05/18/revised PY - 2019/05/20/accepted PY - 2019/5/25/entrez PY - 2019/5/28/pubmed PY - 2019/12/18/medline KW - donor human milk KW - holder pasteurization KW - human milk bank JF - Nutrients JO - Nutrients VL - 11 IS - 5 N2 - BACKGROUND: Holder pasteurization (HoP) is the recommended method of pasteurization for donor human milk (DHM). The aim of the present study was to compare nutritional and microbiological impact on DHM of a new technique of pasteurization based on technical changes of HoP. METHODS: We analyzed milk samples from 25 donors. Each sample, derived from one breast milk expression, was subdivided into three aliquots according to pasteurization: The first was not pasteurized, the second pasteurized by HoP, and the third was pasteurized by modified HoP (MHoP). Each aliquot was assessed as to its microbiological and nutritional profile. Nutritional profile included calcium and triglycerides concentrations detected by spectrophotometry and amino acid levels assessed by high-performance liquid chromatography (HPLC). RESULTS: Triglycerides were significantly lower in pasteurized, by both methods, than in not pasteurized aliquots, while calcium and amino acids concentration were similar. Microbiological profile did not differ between HoP and MHoP aliquots. CONCLUSIONS: HoP and MHoP seem to have similar efficacy in preserving some nutritional characteristics of DHM and to confer similar microbiological safety. MHoP is time-saving and potentially costs-effective when compared to HoP, and it is; therefore, potentially of more interest from a practical point of view. Further studies are needed to confirm these findings. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31121859/A_Modified_Holder_Pasteurization_Method_for_Donor_Human_Milk:_Preliminary_Data_ DB - PRIME DP - Unbound Medicine ER -